List of works - Diana Conte Camerino

A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene

scientific article published on 6 June 2013

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

scientific article

Activation and inhibition of kidney CLC-K chloride channels by fenamates

scientific article published on 21 October 2005

Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission

scientific article published on 28 March 2012

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

scientific article published on 30 May 2013

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

scientific article

Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia.

scientific article published on 9 October 2017

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

scientific article published on January 2013

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

scientific article

Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle

scientific article published on 15 August 2003

Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

scientific article

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block

scientific article

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

scientific article

Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy

scientific article published on 3 October 2012

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

scientific article published in January 2017

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

scientific article published on 03 July 2014

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

scientific article

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

scientific article

Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system

scientific article published on 9 February 2007

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

scientific article published on 8 August 2013

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

scientific article published on 23 July 2008

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor

scientific article

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

scientific article

In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia

scientific article published on 18 September 2012

In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?

scientific article published in January 2012

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

scientific article

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

scientific article published on 12 October 2016

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

scientific article published on 25 January 2003

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

scientific article published in January 2004

Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb-unloaded mice

scientific article published on 9 October 2009

Mechanisms of block of muscle type CLC chloride channels (Review).

scientific article

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels

scientific article

Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials

scientific article published on 21 November 2012

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

scientific article

Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies

scientific article published on 20 June 2016

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

scientific article

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function

scientific article

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

scientific article

On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

scientific article

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

scientific article published in November 2003

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

scientific article published in October 2003

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline

scientific article published on 28 September 2006

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

scientific article

Paving the way for Bartter syndrome type 3 drug discovery: a hope from basic research

scientific article published on 9 June 2017

Pharmacology of CLC Chloride Channels and Transporters

scholarly article by Michael Pusch et al published 2006 in Advances in Molecular and Cell Biology

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness

scientific article

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

scientific article

Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle

scientific article

Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

scientific article

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

scientific article published in July 2016

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

scientific article

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

scientific article published on August 2003

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

scientific article published in March 2010

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

scientific article

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

scientific article

Taurine and skeletal muscle disorders

scientific article published on January 2004

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

scientific article

Therapeutic approaches to ion channel diseases

scientific article

List of works by Diana Conte Camerino

A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

Activation and inhibition of kidney CLC-K chloride channels by fenamates

Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia.

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle

Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia

In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb-unloaded mice

Mechanisms of block of muscle type CLC chloride channels (Review).

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels

Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

Paving the way for Bartter syndrome type 3 drug discovery: a hope from basic research

Pharmacology of CLC Chloride Channels and Transporters

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle

Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

Taurine and skeletal muscle disorders

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

Therapeutic approaches to ion channel diseases