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List of works by Paul Nghiem

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics.

scientific article

ATR Regulates Fragile Site Stability

scientific article (publication date: December 2002)

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

scientific article

ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint

scientific article

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

scientific article published in Nature Communications

Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.

scientific article published on 8 May 2003

Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients ⬇️

scientific article published on October 19, 2010

Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents ⬇️

scientific article published on August 1, 1992

Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States.

scientific article

Basal cell and squamous cell skin cancers

scientific article published on August 2010

Basal cell and squamous cell skin cancers

scientific article published on 01 May 2007

CD200 Expression in Neuroendocrine Neoplasms

scientific article published in September 2017

Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice

scientific article

Case 19-2008: Merkel-cell carcinoma

scientific article published in October 2008

Chemical genetics: elucidating biological systems with small-molecule compounds

scientific article

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

scientific article

Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma

scientific article published on 30 July 2018

Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.

scientific article published on March 2008

Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma

scientific article published on 31 December 2013

Dermatofibrosarcoma protuberans

scientific article published on 01 May 2007

Dermatofibrosarcoma protuberans

scientific article published on 01 March 2012

Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma

scientific article

Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.

scientific article published on April 2008

Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma

scientific article published on June 2013

Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC.

scientific article

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

scientific article

Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain

scientific article published on 12 August 2019

Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

scientific article

Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas

scientific article published on 9 September 2011

Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer

scientific article published on 05 December 2019

Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma

scientific article published on 31 August 2017

Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.

scientific article published on December 2011

Importance of genetic studies in patients with multiple merkel cell carcinomas

scientific article published on 01 November 2012

Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat

scientific article

Interleukin-2 transcriptional block by multifunctional Ca2+/calmodulin kinase

scientific article published on September 1994

Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma

scientific article published on 03 October 2019

Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma

scientific article published on 09 August 2018

Left-sided skin cancers on the arm from driving? Past and future lessons from Australia

scientific article published in December 2011

Merkel cell carcinoma

scientific article published on 01 August 2006

Merkel cell carcinoma

scientific article published on 01 March 2009

Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy

scientific article

Merkel cell carcinoma associated with HIV: review of 14 patients.

scientific article

Merkel cell carcinoma in the age of immunotherapy: Facts and hopes

scientific article published on 7 December 2017

Merkel cell carcinoma patients presenting without a primary lesion have elevated markers of immunity, higher tumor mutation burden and improved survival.

scientific article published on 15 December 2017

Merkel cell carcinoma treatment with radiation: a good case despite no prospective studies

scientific article published on 01 December 2003

Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics

scientific article

Merkel cell carcinoma: if no breslow, then what?

scientific article published on 01 June 2007

Merkel cell carcinoma: more deaths but still no pathway to blame

scientific article published on September 2007

Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors.

scientific article published on 24 July 2008

Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls

scientific article

Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities

scientific article published on 20 March 2013

Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.

scientific article published on 9 September 2011

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy

article

Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers

scientific article published on 6 August 2013

Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells.

scientific article published on 26 July 2017

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.

scientific article

Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations

scientific article published on 11 May 2016

Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma.

scientific article published on October 2013

Patterns of distant metastases in 215 Merkel cell carcinoma patients: Implications for prognosis and surveillance

scientific article published on 27 December 2019

Polyomavirus-driven Merkel cell carcinoma: Prospects for therapeutic vaccine development

scientific article published on 27 March 2020

Prevalent and diverse intratumoral oncoprotein-specific CD8+ T cells within polyoma virus-driven Merkel cell carcinomas

scientific article published on 16 March 2020

Prostaglandin E 1 activates a chloride current in Jurkat T lymphocytes via cAMP‐dependent protein kinase ⬇️

scientific article published on November 1, 1991

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase ⬇️

scientific article published on August 15, 2011

Protection from photodamage by topical application of caffeine after ultraviolet irradiation.

scientific article published on 28 March 2007

Protocol for the examination of specimens from patients with merkel cell carcinoma of the skin

scientific article published on 01 March 2010

Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma

scientific article published in April 2010

Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I

scientific article published on January 2014

Role of skin biopsy to confirm suspected acute graft-vs-host disease: results of decision analysis

scientific article published on 01 February 2006

Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet

scientific article

Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus.

scientific article published on 18 April 2018

The "drug vs graft-vs-host disease" conundrum gets tougher, but there is an answer: the challenge to dermatologists

scientific article published on 01 January 2001

The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation

scientific article published on 22 May 2020

The Protective Role of a Small GTPase RhoE against UVB-induced DNA Damage in Keratinocytes

scientific article published on 14 December 2006

The standard of care for Merkel cell carcinoma should include adjuvant radiation and lymph node surgery

scientific article published on 01 April 2002

Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.

scientific article

Tuberculosis following PD-1 blockade for cancer immunotherapy

scientific article published on 01 January 2019

Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T-cell exhaustion in reducing T-cell responses.

scientific article published on 18 February 2013

Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial

scientific article published on 19 January 2018

p63 Expression in Merkel Cell Carcinoma Predicts Poorer Survival yet May Have Limited Clinical Utility

scientific article

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