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List of works by David Y. Thomas

1H, 13C and 15N resonance assignments of the bb' domains of human protein disulfide isomerase.

scientific article

A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.

scientific article published on 21 January 2016

A Ste6p/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor mating pheromone in Saccharomyces cerevisiae

scientific article published in February 1998

A Yeast Mutant with Temperature-Sensitive Mitochondrial Ribosomes

scientific article published on 01 September 1973

A biochemical genomics screen for substrates of Ste20p kinase enables the in silico prediction of novel substrates

scientific article

A family of yeast expression vectors containing the phage f1 intergenic region

scientific article

A simple method for the large-scale preparation of mitochondria from microorganisms ⬇️

scientific article published on January 1, 1977

A structural overview of the PDI family of proteins

scientific article published on 26 August 2010

Activation of myosin-I by members of the Ste20p protein kinase family

scientific article published in December 1996

Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association.

scientific article

An interaction map of endoplasmic reticulum chaperones and foldases

scientific article

BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex

scientific article

Bright stable luminescent yeast using bacterial luciferase as a sensor

scientific article published in September 2003

CDC42 is required for polarized growth in human pathogen Candida albicans.

scientific article

Ca2+ regulation of interactions between endoplasmic reticulum chaperones

scientific article published in March 1999

Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway.

scientific article published on 8 October 2009

Calnexin phosphorylation: linking cytoplasmic signalling to endoplasmic reticulum lumenal functions.

scientific article published on 06 January 2010

Canadian Chemical Biology Network: biochemistry back to the future

scientific article published on April 2008

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

scientific article published on 06 June 2013

Cell Cycle- and Cln2p-Cdc28p-dependent Phosphorylation of the Yeast Ste20p Protein Kinase

scientific article published in Journal of Biological Chemistry

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

scientific article published on 17 February 2016

Chemogenomic profiling predicts antifungal synergies.

scientific article

Cleavage of prosomatostatins by the yeast Yap3 and Kex2 endoprotease.

scientific article published on January 1994

Cloning and characterization of the SKI3 gene of Saccharomyces cerevisiae demonstrates allelism to SKI5

article

Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1.

scientific article published on November 1993

Cold adaptation in budding yeast

scientific article

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines.

scientific article published on 14 January 2013

Conformational changes induced in the endoplasmic reticulum luminal domain of calnexin by Mg-ATP and Ca2+.

scientific article published on July 1995

Conserved in vivo phosphorylation of calnexin at casein kinase II sites as well as a protein kinase C/proline-directed kinase site.

scientific article

Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans

scientific article

Control of expression, glycosylation, and secretion of HIV-1 gp120 by homologous and heterologous signal sequences

scientific article published on October 1994

Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP.

scientific article

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

scientific article

Correctors of protein trafficking defects identified by a novel high-throughput screening assay

scientific article

Correctors of the basic trafficking defect of the mutant F508del-CFTR that causes cystic fibrosis.

scientific article published on 24 May 2013

Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae.

scientific article published on October 2002

Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae,

scientific article

Crystal structure of the bb' domains of the protein disulfide isomerase ERp57

scientific article

Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors

scientific article

DePIE: Designing Primers for Protein Interaction Experiments.

scientific article

Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking.

scientific article published on 12 September 2012

Drosophila melanogaster Thor and response to Candida albicans infection.

scientific article published on 2 February 2007

ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER

scientific journal article

ERp57 and PDI: multifunctional protein disulfide isomerases with similar domain architectures but differing substrate-partner associations.

scientific article published on December 2006

Editorial

scientific article published on 20 May 2017

Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport

scientific article

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

scientific article published on 26 August 2011

Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

scientific article published in Journal of Biological Chemistry

Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptide

scientific article published on February 1991

Escherichia coli plasmid vectors containing synthetic translational initiation sequences and ribosome binding sites fused with the lacZ gene.

scientific article

Experimental design and statistical methods for improved hit detection in high-throughput screening.

scientific article

Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II.

scientific article

Expression in yeast of a cDNA copy of the K2 killer toxin gene

scientific article published in May 1991

Expression of MF alpha 1 in MATa cells supersensitive to alpha-factor leads to self-arrest

scientific article published in September 1988

Expression of functional papain precursor in Saccharomyces cerevisiae: rapid screening of mutants.

scientific article published on February 1993

Expression of the Saccharomyces cerevisiae Kex2p endoprotease in inset cells. Evidence for a carboxy-terminal autoprocessing event

scientific article

Functional characterization of myosin I tail regions in Candida albicans

scientific article

Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes

article

Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase.

scientific article

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

scientific article published on 25 June 2014

Identification and crystallization of a protease-resistant core of calnexin that retains biological activity.

scientific article

Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.

scientific article published on February 2011

Identification of new cysteine protease gene isoforms in Trypanosoma cruzi.

scientific article published in October 1994

Identifying regulatory subnetworks for a set of genes

scientific article

Inhibition of mitochondrial synthesis in yeast by erythromycin: cytoplasmic and nuclear factors controlling resistance

scientific article published on 01 February 1968

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

scientific article published in January 1998

Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases

scientific article

Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.

scientific article published on 18 May 2016

Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

scientific article (publication date: 10 December 1999)

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

scientific article published on 22 October 2015

Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae.

scientific article

Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy.

scientific article

Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import.

scientific article

Novel pharmacological strategies to treat cystic fibrosis.

scientific article published on February 2013

Organization of the Sec61 translocon, studied by high resolution native electrophoresis.

scientific article

Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells

scientific article

PCR-based unidirectional deletion method for creation of comprehensive cDNA libraries.

scientific article published on 2 March 2005

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes.

scientific article

Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function

scientific article

Polymorphism in the lipase genes of Geotrichum candidum strains

scientific article published in January 1994

Population genomics of drug resistance in Candida albicans.

scientific article

Predicting the subcellular localization of viral proteins within a mammalian host cell

scientific article published on 4 April 2006

Processing of Kex2 pro-region at two interchangeable cleavage sites

scientific article published on 01 May 1993

Protein quality control in the ER: the recognition of misfolded proteins

scientific article published on 25 March 2010

Proteomics characterization of abundant Golgi membrane proteins

scientific article (publication date: 16 February 2001)

Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans

scientific article published in November 2001

Refining protein subcellular localization

scientific article

Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p.

scientific article

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence

scientific article

Role of the Endoplasmic Reticulum Chaperone Calnexin in Subunit Folding and Assembly of Nicotinic Acetylcholine Receptors

scientific article published in Journal of Biological Chemistry

Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus.

scientific article

Saccharomyces cerevisiae plasmid, Scp or 2 mum: intracellular distribution, stability and nucleosomal-like packaging

scientific article published on August 1980

Secretion, purification and characterization of a soluble form of the yeast KEX1-encoded protein from insect-cell cultures

scientific article published on January 1994

Solution structure of the bb' domains of human protein disulfide isomerase

scientific article

Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system

scientific article

Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.

scientific article

Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain

scientific article

Structural and Functional Roles of Asparagine 175 in the Cysteine Protease Papain

scientific article published in Journal of Biological Chemistry

Structure of the catalytic a(0)a fragment of the protein disulfide isomerase ERp72

scientific article

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72

scientific article

Synthesis of Mitochondrial Proteins in an Escherichia coli Cell-Free System Directed by Yeast Mitochondrial DNA

scientific article published on 01 August 1975

Synthesis of a human insulin gene VI. expression of the synthetic proinsulin gene in yeast

article

Synthesis of cytochromec oxidase polypeptides in anEscherichia coli cell-free system directed bySaccharomyces cerevisiae mitochondrial DNA ⬇️

scientific article published on January 7, 1977

Synthesis of human insulin gene VIII. Construction of expression vectors for fused proinsulin production in Escherichia coli

article

The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation

scientific article published on 4 January 2004

The HIV-1 Env Protein Signal Sequence Retards Its Cleavage and Down-regulates the Glycoprotein Folding

article

The Hera database and its use in the characterization of endoplasmic reticulum proteins

scientific article published on 29 January 2004

The Phosphorylation Site for Ste20p-like Protein Kinases Is Essential for the Function of Myosin-I in Yeast

scientific article published in Journal of Biological Chemistry

The Yeast Proprotein Convertase Encoded by YAP3 Is a Glycophosphatidylinositol-anchored Protein That Localizes to the Plasma Membrane ⬇️

scientific article published on September 1, 1995

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.

scientific article

The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation.

scientific article

The expression in Escherichia coli of a synthetic gene coding for the precursor of papain is prevented by its own putative signal sequence

scientific article published in April 1989

The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing

scientific article published in March 1992

The yeast KEX-2-processing endoprotease is active in the Golgi apparatus of transfected NIH 3T3 fibroblasts

scientific article published on October 1990

Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition

scientific article

Transformation of Saccharomyces cerevisiae with plasmids containing fragments of yeast 2 ? DNA and a suppressor tRNA gene

article

Ubiquitin gene expression: response to environmental changes

scientific article published in July 1991

Unravelling druggable signalling networks that control F508del-CFTR proteostasis

scientific article published on 23 December 2015

Use of Dominant Negative Mutations in Analysis of G Protein Function in Saccharomyces cerevisiae

scientific article published on 01 January 2002

Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing.

scientific article

Yeast killer toxin: Site-directed mutations implicate the precursor protein as the immunity component

scientific article published on 01 July 1986

gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer

scientific journal article

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