List of works - Keiko Yamamoto

17-OxoDHA Is a PPARα/γ Dual Covalent Modifier and Agonist

scientific article

1α,25-Dihydroxyvitamin D3-24-Hydroxylase (CYP24) Hydroxylates the Carbon at the End of the Side Chain (C-26) of the C-24-fluorinated Analog of 1α,25-Dihydroxyvitamin D3

scientific article published in Journal of Biological Chemistry

2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism

scientific article

22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor

scientific article

22S-butyl-1alpha,24R-dihydroxyvitamin D3: recovery of vitamin D receptor agonistic activity

scientific article

4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis

scientific article published on 10 January 2008

A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol

scientific article published on June 2010

A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group

scientific article

A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor

scientific article

A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid

scientific article published on 19 September 2017

Alanine scanning mutational analysis of the ligand binding pocket of the human Vitamin D receptor

scientific article published on 16 January 2007

Analogs of 1alpha,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs

scientific article published on 2 March 2006

Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics.

scientific article

Biomimetic total synthesis of (+/-)-8-oxoerymelanthine.

scientific article published in August 2009

Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands

scientific article

CYP24A1 as a Potential Target for Cancer Therapy ⬇️

scientific article published on January 1, 2014

Characterization of covalent bond formation between PPARγ and oxo-fatty acids

scientific article

Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases

scientific article published on 13 July 2006

Comparison of Metabolism of Sesamin and Episesamin by Drug-Metabolizing Enzymes in Human Liver

scientific article published on 29 June 2012

Conformationally Restricted Analogs of 1α,25-Dihydroxyvitamin D3and Its 20-Epimer: Compounds for Study of the Three-Dimensional Structure of Vitamin D Responsible for Binding to the Receptor

scientific article published on 01 July 1996

Conformation−Function Relationship of Vitamin D: Conformational Analysis Predicts Potential Side-Chain Structure

scientific article published on 01 April 1998

Construction of a series of intermediates in the β-oxidation pathway from THA to EPA via DHA in free acid form

scientific article published on 04 July 2018

Design and Characterization of a Selenium-Containing Inhibitor of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa), a Zinc-Containing Metalloprotease

scientific article published on 27 August 2012

Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone

scientific article published on 03 December 2018

Efficient Synthesis of the Very-Long-Chain n-3 Fatty Acids, Tetracosahexaenoic Acid (C24:6n-3) and Tricosahexaenoic Acid (C23:6n-3)

scientific article published on 24 February 2011

Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).

scientific article published on 14 April 2010

From the Cover: Structural Determinants of the Position of 2,3',4,4',5-Pentachlorobiphenyl (CB118) Hydroxylation by Mammalian Cytochrome P450 Monooxygenases

scientific article published on 13 May 2016

Helix12-Stabilization Antagonist of Vitamin D Receptor

scientific article

Homology modeling of human 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5.

scientific article published in May 2004

Identification of a highly potent vitamin D receptor antagonist: (25S)-26-Adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3 (ADMI3)

scientific article published on 12 December 2006

Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents

scientific article published in February 2005

Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands

scientific article published on 11 July 2018

Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1.

scientific article

In vivo metabolism of 24 R,25-dihydroxyvitamin D3: structure of its major bile metabolite

scientific article published on 01 June 1997

Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1.

scientific article

Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis.

scientific article published in March 2003

Intravenous and oral administrations of DD2 [7-Amino-2-(sulfanylmethyl)heptanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrombosis

scientific article published on 12 July 2012

Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1.

scientific article published on 6 June 2007

Ligand Recognition by Vitamin D Receptor: Total Alanine Scanning Mutational Analysis of the Residues Lining the Ligand Binding Pocket of Vitamin D Receptor

scientific article published on 01 January 2006

Ligand recognition by the vitamin D receptor

scientific article

Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists

scientific article published on 28 December 2020

Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls

scientific article

Mechanism of the differentiating action of 25-hydroxyvitamin D3 endoperoxides in human myeloid leukemia cells (HL-60)

scientific article published on 01 September 1985

New derivatives of 1alpha,25-dihydroxy-19-norvitamin D3 with two substituents at C-2: synthesis and biological activity

scientific article published in March 2005

On-site reaction for PPARγ modification using a specific bifunctional ligand

scientific article published on 23 October 2017

Phagocytic cells metabolize 25-hydroxyvitamin D3 to 10-oxo-19-nor-25-hydroxyvitamin D3 and a new metabolite, 8 alpha,25-dihydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one

scientific article published on June 1987

Potent antagonist for the vitamin D receptor: vitamin D analogues with simple side chain structure

scientific article published on August 2010

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

scientific article published on August 2014

Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity.

scientific article

Rational design, synthesis, and biological activity of novel conformationally restricted vitamin D analogues, (22R)- and (22S)-22-ethyl-1,25-dihydroxy-23,24-didehydro-24a,24b-dihomo-20-epivitamin D(3).

scientific article published in April 2002

Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin D(3)-binding and protein folding.

scientific article published on 06 February 2007

SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity

scientific article published on 14 November 2016

Selective inhibition of methoxyflavonoids on human CYP1B1 activity

scientific article published on 13 July 2010

Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme

scientific article

Structural basis for the activation of PPARgamma by oxidized fatty acids

scientific article

Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group

scientific article published on 23 May 2018

Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3′,4,4′,5-pentachlorobiphenyl

scientific article published on 22 January 2011

Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.

scientific article published on 2 October 2003

Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor

scientific article

Structure–activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position

scientific article published on 03 November 2006

Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells ⬇️

scientific article published on September 3, 2011

Syntheses and differentiating action of vitamin D endoperoxides. Singlet oxygen adducts of vitamin D derivatives in human myeloid leukemia cells (HL-60)

scientific article published on 01 September 1985

Synthesis and biological activities of new 1alpha,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain

scientific article published on 24 February 2006

Synthesis and structure-activity relationships of 16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs having side chains of different sizes

scientific article published on 6 November 2007

Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents

scientific article

The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor

scientific article

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain

scholarly article

Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model.

scientific article

Three-dimensional structure-function relationship of vitamin D: Side chain location and various activities

scientific article published on 01 April 1999

Two-dimensional alanine scanning mutational analysis of the interaction between the vitamin D receptor and its ligands: studies of A-ring modified 19-norvitamin D analogs

scientific article

Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action

scientific article published on 27 September 2017

Vitamin D receptor: ligand recognition and allosteric network

scientific article published in February 2006

Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators

scientific article published on 26 February 2007

List of works by Keiko Yamamoto

17-OxoDHA Is a PPARα/γ Dual Covalent Modifier and Agonist

1α,25-Dihydroxyvitamin D3-24-Hydroxylase (CYP24) Hydroxylates the Carbon at the End of the Side Chain (C-26) of the C-24-fluorinated Analog of 1α,25-Dihydroxyvitamin D3

2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism

22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor

22S-butyl-1alpha,24R-dihydroxyvitamin D3: recovery of vitamin D receptor agonistic activity

4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis

A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol

A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group

A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor

A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid

Alanine scanning mutational analysis of the ligand binding pocket of the human Vitamin D receptor

Analogs of 1alpha,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs

Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics.

Biomimetic total synthesis of (+/-)-8-oxoerymelanthine.

Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands

CYP24A1 as a Potential Target for Cancer Therapy ⬇️

Characterization of covalent bond formation between PPARγ and oxo-fatty acids

Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases

Comparison of Metabolism of Sesamin and Episesamin by Drug-Metabolizing Enzymes in Human Liver

Conformationally Restricted Analogs of 1α,25-Dihydroxyvitamin D3and Its 20-Epimer: Compounds for Study of the Three-Dimensional Structure of Vitamin D Responsible for Binding to the Receptor

Conformation−Function Relationship of Vitamin D: Conformational Analysis Predicts Potential Side-Chain Structure

Construction of a series of intermediates in the β-oxidation pathway from THA to EPA via DHA in free acid form

Design and Characterization of a Selenium-Containing Inhibitor of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa), a Zinc-Containing Metalloprotease

Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone

Efficient Synthesis of the Very-Long-Chain n-3 Fatty Acids, Tetracosahexaenoic Acid (C24:6n-3) and Tricosahexaenoic Acid (C23:6n-3)

Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).

From the Cover: Structural Determinants of the Position of 2,3',4,4',5-Pentachlorobiphenyl (CB118) Hydroxylation by Mammalian Cytochrome P450 Monooxygenases

Helix12-Stabilization Antagonist of Vitamin D Receptor

Homology modeling of human 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5.

Identification of a highly potent vitamin D receptor antagonist: (25S)-26-Adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3 (ADMI3)

Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents

Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands

Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1.

In vivo metabolism of 24 R,25-dihydroxyvitamin D3: structure of its major bile metabolite

Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1.

Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis.

Intravenous and oral administrations of DD2 [7-Amino-2-(sulfanylmethyl)heptanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrombosis

Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1.

Ligand Recognition by Vitamin D Receptor: Total Alanine Scanning Mutational Analysis of the Residues Lining the Ligand Binding Pocket of Vitamin D Receptor

Ligand recognition by the vitamin D receptor

Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists

Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls

Mechanism of the differentiating action of 25-hydroxyvitamin D3 endoperoxides in human myeloid leukemia cells (HL-60)

New derivatives of 1alpha,25-dihydroxy-19-norvitamin D3 with two substituents at C-2: synthesis and biological activity

On-site reaction for PPARγ modification using a specific bifunctional ligand

Phagocytic cells metabolize 25-hydroxyvitamin D3 to 10-oxo-19-nor-25-hydroxyvitamin D3 and a new metabolite, 8 alpha,25-dihydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one

Potent antagonist for the vitamin D receptor: vitamin D analogues with simple side chain structure

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity.

Rational design, synthesis, and biological activity of novel conformationally restricted vitamin D analogues, (22R)- and (22S)-22-ethyl-1,25-dihydroxy-23,24-didehydro-24a,24b-dihomo-20-epivitamin D(3).

Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin D(3)-binding and protein folding.

SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity

Selective inhibition of methoxyflavonoids on human CYP1B1 activity

Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme

Structural basis for the activation of PPARgamma by oxidized fatty acids

Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group

Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3′,4,4′,5-pentachlorobiphenyl

Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.

Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor

Structure–activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position

Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells ⬇️

Syntheses and differentiating action of vitamin D endoperoxides. Singlet oxygen adducts of vitamin D derivatives in human myeloid leukemia cells (HL-60)

Synthesis and biological activities of new 1alpha,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain

Synthesis and structure-activity relationships of 16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs having side chains of different sizes

Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents

The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain

Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model.

Three-dimensional structure-function relationship of vitamin D: Side chain location and various activities

Two-dimensional alanine scanning mutational analysis of the interaction between the vitamin D receptor and its ligands: studies of A-ring modified 19-norvitamin D analogs

Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action

Vitamin D receptor: ligand recognition and allosteric network

Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators