List of works - Keith Matthews

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

scientific article published on 28 February 2015

35 years of molecular and biochemical parasitology.

scientific article published in July 2014

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development

scientific article published on 11 October 2018

A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation

scientific article published on 21 September 2020

A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension.

scientific article published in September 2004

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.

scientific article

A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle.

scientific article published in August 2004

A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome.

scientific article published on May 2000

A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis

scientific article published on 01 April 2003

A short bifunctional element operates to positively or negatively regulate ESAG9 expression in different developmental forms of Trypanosoma brucei

scientific article published on 22 March 2013

A surface transporter family conveys the trypanosome differentiation signal

scientific article

A systematic analysis of <i>Trypanosoma brucei</i> chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination

scientific article published on 18 August 2021

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei

scientific article published on 26 March 2020

Assembling the components of the quorum sensing pathway in African trypanosomes

scientific article

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.

scientific article

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.

scientific article published on September 2006

Controlling and coordinating development in vector-transmitted parasites.

scientific article published on March 2011

Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei

scientific article published on 21 October 2019

Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

scientific article

Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements.

scientific article published on 27 February 2009

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein.

scientific article published in August 2005

Distinguishing functions of trypanosomatid protein kinases

scientific article published in 2022

Drug resistance in eukaryotic microorganisms

scientific article

Emerging challenges in understanding trypanosome antigenic variation

scientific article published on 01 December 2017

Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei.

scientific article published on 12 May 2006

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

scientific article

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.

scientific article

Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei

scientific article

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

scientific article published on 17 January 2014

Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development.

scientific article published on 16 October 2006

Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei.

scientific article published on 7 June 2012

Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei.

scientific article

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression

scientific article

Interspecies quorum sensing in co-infections can manipulate trypanosome transmission potential

scientific article

Investigating mammalian tyrosine phosphatase inhibitors as potential 'piggyback' leads to target Trypanosoma brucei transmission

scientific article

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. ⬇️

scientific article published on 09 April 2013

Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei

article

Mitochondrial development during life cycle differentiation of African trypanosomes: evidence for a kinetoplast-dependent differentiation control point.

scientific article

Molecular control of irreversible bistability during trypanosome developmental commitment

scientific article published on 19 October 2015

Molecular regulation of the life cycle of African trypanosomes.

scientific article published on January 2004

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway.

scientific article published on 14 April 2015

New discoveries in the transmission biology of sleeping sickness parasites: applying the basics.

scientific article published on 05 June 2010

Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes

scientific article published on 25 June 2018

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

scientific article published on 29 November 2018

Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host.

scientific article

Regulation of surface coat exchange by differentiating African trypanosomes

scientific article published on 09 March 2006

Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites.

scientific article

Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.

scientific article published on 18 April 2007

Stable transformation of pleomorphic bloodstream form Trypanosoma brucei.

scientific article published on 5 July 2013

Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis

scientific article published on 24 March 2017

Targeting new drugs with choline metabolism

scientific article published on October 2012

Targeting pathogen metabolism without collateral damage to the host

scientific article

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream

scientific article published on 28 June 2017

The application of genomic technology to combat parasitic disease.

scientific article published on January 2004

The genomic basis of host and vector specificity in non-pathogenic trypanosomatids

scientific article published on 01 April 2022

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei.

scientific article published on 2 December 2011

The silicon trypanosome.

scientific article published on 06 May 2010

The trypanosome Rab-related proteins RabX1 and RabX2 play no role in intracellular trafficking but may be involved in fly infectivity.

scientific article

The within-host dynamics of African trypanosome infections

scientific article published on August 2015

The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis ⬇️

scientific article published on September 1, 2012

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

scientific article

Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods.

scientific article published on 23 February 2018

tbCPSF30 depletion by RNA interference disrupts polycistronic RNA processing in Trypanosoma brucei.

scientific article published on 13 May 2003

List of works by Keith Matthews

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

35 years of molecular and biochemical parasitology.

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development

A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation

A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension.

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.

A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle.

A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome.

A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis

A short bifunctional element operates to positively or negatively regulate ESAG9 expression in different developmental forms of Trypanosoma brucei

A surface transporter family conveys the trypanosome differentiation signal

A systematic analysis of <i>Trypanosoma brucei</i> chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei

Assembling the components of the quorum sensing pathway in African trypanosomes

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.

Controlling and coordinating development in vector-transmitted parasites.

Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei

Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements.

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein.

Distinguishing functions of trypanosomatid protein kinases

Drug resistance in eukaryotic microorganisms

Emerging challenges in understanding trypanosome antigenic variation

Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei.

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.

Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development.

Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei.

Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei.

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression

Interspecies quorum sensing in co-infections can manipulate trypanosome transmission potential

Investigating mammalian tyrosine phosphatase inhibitors as potential 'piggyback' leads to target Trypanosoma brucei transmission

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. ⬇️

Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei

Mitochondrial development during life cycle differentiation of African trypanosomes: evidence for a kinetoplast-dependent differentiation control point.

Molecular control of irreversible bistability during trypanosome developmental commitment

Molecular regulation of the life cycle of African trypanosomes.

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway.

New discoveries in the transmission biology of sleeping sickness parasites: applying the basics.

Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host.

Regulation of surface coat exchange by differentiating African trypanosomes

Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites.

Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.

Stable transformation of pleomorphic bloodstream form Trypanosoma brucei.

Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis

Targeting new drugs with choline metabolism

Targeting pathogen metabolism without collateral damage to the host

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream

The application of genomic technology to combat parasitic disease.

The genomic basis of host and vector specificity in non-pathogenic trypanosomatids

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei.

The silicon trypanosome.

The trypanosome Rab-related proteins RabX1 and RabX2 play no role in intracellular trafficking but may be involved in fly infectivity.

The within-host dynamics of African trypanosome infections

The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis ⬇️

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods.

tbCPSF30 depletion by RNA interference disrupts polycistronic RNA processing in Trypanosoma brucei.