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List of works by Craig R. Roy

A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells

scientific article

A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles

scientific article

A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalF

scientific article

A Rab-centric perspective of bacterial pathogen-occupied vacuoles.

scientific article published on September 2013

A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes

scientific article published on January 2002

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis

scientific article

A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel

scientific article published on 21 May 2018

AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.

scientific article published on 11 February 2014

Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion.

scientific article

Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding

scientific article published on 18 February 2020

Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila

scientific article published in January 2005

Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors

scientific article

Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila

scientific article published on 23 February 2009

Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila.

scientific article published on September 2011

Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila

scientific article published on May 2006

Autophagy and bacterial infection: an evolving arms race.

scientific article published on 20 July 2013

Bacterial FIC Proteins AMP Up Infection.

scientific article published on 17 March 2009

Bacterial type IV secretion systems in human disease

scientific article published on 08 June 2009

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

scientific article published on 20 February 2020

Coxiella burnetii Secretion Systems ⬇️

scientific article published on January 1, 2012

Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system

scientific article published in August 2003

Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria

scientific article

Cytosolic detection of flagellin: a deadly twist

scientific article published on 01 June 2006

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

scientific article published on 24 August 2011

Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole

scientific article

Eukaryotic cells and microbial pathogens: a familiar couple take centre stage

scientific article published on 01 January 2003

Exploitation of macrophages as a replication niche by Legionella pneumophila: response

scientific article published on 01 February 2000

Exploitation of the endoplasmic reticulum by bacterial pathogens.

scientific article

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

scientific article

Host Pathways Important for Coxiella burnetii Infection Revealed by Genome-Wide RNA Interference Screening ⬇️

scientific article published on January 29, 2013

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii

scientific article published on 28 August 2019

Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes.

scientific article published on 2 August 2013

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth

scientific article published on 01 November 2000

Immunology: professional secrets

scientific article published in September 2003

Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection.

scientific article published on 28 January 2013

Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein

scientific article

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites

scientific article published on 01 December 2002

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

scientific article published on May 1998

Legionella pneumophila excludes autophagy adaptors from the ubiquitin-labeled vacuole in which it resides

scientific article published on 01 June 2020

Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b.

scientific article published on 15 February 2010

Legionella pneumophila proteins that regulate Rab1 membrane cycling

scientific article published on 21 October 2007

Legionella pneumophilaSubversion of Host Vesicular Transport by SidC Effector Proteins

scientific article

Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation

scientific article published in June 2003

Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle.

scientific article

Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins.

scientific article

Manipulation of host membrane machinery by bacterial pathogens

scientific article published on 09 June 2010

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

scientific article published on 08 June 2020

Meeting report - Arf and Rab family G proteins

scientific article published in December 2013

Microtubule motors control membrane dynamics of Salmonella-containing vacuoles

scientific article published on 17 February 2004

Modulation of Host Cell Function by Legionella pneumophila Type IV Effectors ⬇️

scientific article published on January 1, 2010

Modulation of Rab GTPase function by a protein phosphocholine transferase

scientific journal article

Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot/Icm system

scientific article

Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila

scientific article published on 8 September 2008

MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires' disease

scientific article published on June 2006

NDP52: the missing link between ubiquitinated bacteria and autophagy. ⬇️

scientific article published on November 2009

On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF

scientific article

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.

scientific article published on 13 October 2013

Pathogen-endoplasmic-reticulum interactions: in through the out door

scientific article

Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth

scientific article published on 01 June 1999

Processing and major histocompatibility complex class II presentation of Legionella pneumophila antigens by infected macrophages

scientific article published on April 2005

Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila

scientific article

Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems.

scientific article

Show me the substrates: modulation of host cell function by type IV secretion systems.

scientific article

Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.

scientific article

Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM

scientific article

Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain

scientific article

Subversion of membrane transport pathways by vacuolar pathogens ⬇️

scientific article published on November 28, 2011

The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes

scientific article

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

scientific article published on 29 January 2006

The Coxiella burnetii Dot/Icm System Creates a Comfortable Home through Lysosomal Renovation ⬇️

scientific article published on October 18, 2011

The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication ⬇️

scientific article published on May 26, 2011

The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter ⬇️

scientific article published on November 1, 2001

The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation.

scientific article

The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation

scientific article

The Legionella pneumophila Effector RavY Contributes to a Replication-Permissive Vacuolar Environment during Infection

scientific article published on 20 September 2021

The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism ⬇️

scientific article published on July 2, 2013

The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.

scientific article published on January 2012

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor

scientific article published on 13 August 2006

The capping domain in RalF regulates effector functions

scientific article (publication date: 2012)

The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins

scientific article

The road less traveled: transport of Legionella to the endoplasmic reticulum

scientific article

The role of Rab GTPases in the transport of vacuoles containingLegionella pneumophilaandCoxiella burnetii ⬇️

scientific article published on December 1, 2012

The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site

scientific article published in November 2004

Trimming the fat: a Brucella abortus survival strategy

scientific article published on 01 June 2005

Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages

scientific article published on 01 October 1996

Vacuolar pathogens value membrane integrity.

scientific article published on 16 February 2012

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