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List of works by Osamu Handa

A Case of Inoperable Duodenal Cancer Achieving Long-Term Survival after Multidisciplinary Treatment ⬇️

scientific article published on February 18, 2012

A multicenter, randomized, double-blind, placebo-controlled trial of high-dose rebamipide treatment for low-dose aspirin-induced moderate-to-severe small intestinal damage

scientific article

A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice

scientific article published on 18 September 2006

A novel vitamin E derivative (TMG) protects against gastric mucosal damage induced by ischemia and reperfusion in rats

scientific article published in January 2003

A review of the mechanism and prophylaxis of acetyl salicylic acid-induced injury of the small intestine.

scientific article published on 3 April 2018

Ability of a novel blue laser imaging system for the diagnosis of colorectal polyps.

scientific article

Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1 ⬇️

scientific article published on August 23, 2012

Analysis of cardiopulmonary stress during endoscopy: is unsedated transnasal esophagogastroduodenoscopy appropriate for elderly patients?

scientific article

Anti-inflammatory effects of carbon monoxide-releasing molecule on trinitrobenzene sulfonic acid-induced colitis in mice

scientific article published on 19 January 2014

Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis

scientific article published on 01 August 2006

Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice.

scientific article published on March 2009

Antitumor effect of whole body hyperthermia with alpha-galactosylceramide in a subcutaneous tumor model of colon cancer.

scientific article published on November 2007

As a host society to SFRRI 2014 in Kyoto.

scientific article published on January 2014

Assessment of Endoscopic Mucosal Healing of Ulcerative Colitis Using Linked Colour Imaging, a Novel Endoscopic Enhancement System.

scientific article

Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling

scientific article published on April 2008

BTB and CNC Homolog 1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice

scientific article published on 01 March 2013

Blocking of NF-kappaB activation enhances the tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line.

scientific article published in April 2003

Blue Laser Imaging-Bright Improves Endoscopic Recognition of Superficial Esophageal Squamous Cell Carcinoma.

scientific article

Bofutsushosan, an Oriental Herbal Medicine, Attenuates the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes Associated with the Increase in Their Expression of Uncoupling Protein 1 in High-Fat Diet-Fed Male KK/Ta mice

scientific article

CV-11974, angiotensin II type I receptor antagonist, reduces the severity of indomethacin-induced rat enteritis

scientific article published on 01 September 2007

CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling.

scientific article published on 27 October 2006

Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation

scientific article published on 16 May 2018

Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts.

scientific article

Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice

scientific article published on 18 November 2010

Cardiac myocytes activated by septic plasma promote neutrophil transendothelial migration: role of platelet-activating factor and the chemokines LIX and KC.

scientific article published on 26 February 2004

Changes in Intestinal Motility and Gut Microbiota Composition in a Rat Stress Model.

scientific article

Clinical and Pathological Challenges in the Diagnosis of Gastric-Type Differentiated Adenocarcinoma in the Stomach: A Study of Endoscopic Submucosal Dissection Cases

scientific article published on 18 September 2018

Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats ⬇️

scientific article published on September 3, 2012

Correction to: Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects

scientific article published on 01 January 2019

Cytotoxic T lymphocyte-associated antigen 4 inhibition increases the antitumor activity of adoptive T-cell therapy when carried out with naïve rather than differentiated T cells.

scientific article

Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model

scientific article published in January 2011

Decrease of the regulatory T-cell population by adoptive T-cell transfer in a mouse colorectal cancer transplant model.

scientific article

Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells.

scientific article

Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study.

scientific article

Dichotomous effect of ultraviolet B on the expression of corneodesmosomal enzymes in human epidermal keratinocytes.

scientific article

Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects

scientific article published on 20 June 2018

Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice

scientific article published on January 2003

Early-Stage Gastric Cancer Can Be Found in Improved Atrophic Mucosa over Time from Successful Helicobacter pylori Eradication

scientific article published on 14 March 2017

Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells.

scientific article published on July 2010

Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats

scientific article published on March 2006

Effects of anticancer agents on cell viability, proliferative activity and cytokine production of peripheral blood mononuclear cells

scientific article published on 20 November 2012

Efficacy of Magnifying Narrow Band Imaging for Delineating Horizontal Margins of Early Gastric Cancer

scientific article published on 13 November 2018

Efficacy of hyaluronic acid in endoscopic mucosal resection of colorectal tumors

scientific article published on 01 February 2011

Efficacy of magnifying endoscopy with flexible spectral imaging color enhancement in the diagnosis of colorectal tumors.

scientific article published in January 2011

Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice

scientific article published on 28 October 2010

Endoscopic diagnosis of small intestinal diseases.

scientific article

Endoscopic mucosal resection with 0.13% hyaluronic acid solution for colorectal polyps less than 20 mm: a randomized controlled trial

scientific article published in August 2012

Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice

scientific article published in May 2003

Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa

scientific article

FGF19 protects colonic epithelial cells against hydrogen peroxide.

scientific article

Gastric peroxisome proliferator activator receptor-γ expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats ⬇️

scientific article published on February 26, 2011

Gene expression profiles of diabetic mice treated with whole body hyperthermia: A high-density DNA microarray analysis

scientific article published on 01 January 2010

Gene expression profiles on hypoxia and reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis

scientific article published on 20 June 2006

Ginsenoside Rb1 promotes intestinal epithelial wound healing through ERK and Rho signaling

scientific article published on 22 November 2018

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

scientific article published on 20 May 2019

Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells.

scientific article published on 17 June 2011

Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer.

scientific article

Heat-shock protein 70-overexpressing gastric epithelial cells are resistant to indomethacin-induced apoptosis

scientific article

Helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor 2.

scientific article published on January 2007

Helicobacter pylori eradication therapy outcome according to clarithromycin susceptibility testing in Japan

scientific article published on 05 May 2020

Helicobacter pylori: a ROS-inducing bacterial species in the stomach.

scientific article published on 05 September 2010

Heme oxygenase-1 (Hsp32) is involved in the protection of small intestine by whole body mild hyperthermia from ischemia/reperfusion injury in rat.

scientific article published in November 2005

Heme oxygenase-1 prevents murine intestinal inflammation

scientific article published on 12 July 2018

Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-1.

scientific article published in April 2013

Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin.

scientific article

Histopathological analysis of cold snare polypectomy and its indication for colorectal polyps 10-14 mm in diameter.

scientific article published on 3 February 2017

Hypersensitivity Reactions to Oxaliplatin: Identifying the Risk Factors and Judging the Efficacy of a Desensitization Protocol.

scientific article published on 7 April 2015

Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins.

scientific article

Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells.

scientific article published on May 2007

Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin.

scientific article

Impact of Helicobacter pylori eradication on circulating adiponectin in humans

scientific article published on 20 November 2012

Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection.

scientific article published on 13 March 2018

In vivo imaging of intestinal helminths by capsule endoscopy.

scientific article

Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis.

scientific article

Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: a transcriptome analysis.

scientific article

Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression

scientific article published on 22 January 2010

Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1.

scientific article published in April 2009

Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori

scientific article published on November 2002

Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells

scientific article published on 18 February 2009

Inhibitory effects of catechins on neutrophil-dependent gastric inflammation

scientific article published on January 2002

Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells

scientific article

L-menthol improves adenoma detection rate during colonoscopy: a randomized trial

scientific article published on 26 February 2014

Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1.

scientific article

Linked color imaging improves the visibility of various featured colorectal polyps in an endoscopist's visibility and color difference value.

scientific article published on 19 July 2017

Lipid hydroperoxide-derived modification of proteins in gastrointestinal tract.

scientific article published on January 2014

Long fish tapeworm in the intestine: an in situ observation by capsule endoscopy

scientific article published on 15 February 2011

MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid

scientific article published on 01 October 2013

Magnifying Endoscopy with Blue Laser Imaging Improves the Microstructure Visualization in Early Gastric Cancer: Comparison of Magnifying Endoscopy with Narrow-Band Imaging

scientific article published on 30 August 2017

Methylparaben potentiates UV-induced damage of skin keratinocytes

scientific article

Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: a nutrigenomic approach

scientific article published on 01 October 2006

Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects

scientific article published on 05 February 2019

Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats.

scientific article published on 28 February 2018

Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics

scientific article published on 10 July 2011

New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid

scientific article (publication date: 2014)

New-generation narrow band imaging improves visibility of polyps: a colonoscopy video evaluation study.

scientific article published on 25 January 2016

Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells ⬇️

scientific article published on June 2, 2011

Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA.

scientific article

Partially hydrolyzed guar gum enhances colonic epithelial wound healing via activation of RhoA and ERK1/2.

scientific article published on 15 June 2016

Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer

scientific article published on 31 January 2018

Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.

scientific article

Phase II trial of combined regional hyperthermia and gemcitabine for locally advanced or metastatic pancreatic cancer

scientific article published on 27 July 2012

Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade

scientific article published in January 2002

Points of control exerted along the macrophage-endothelial cell-polymorphonuclear neutrophil axis by PECAM-1 in the innate immune response of acute colonic inflammation

scientific article published in August 2008

Possibility of ex vivo animal training model for colorectal endoscopic submucosal dissection

scientific article published on 10 July 2012

Prediction and treatment of difficult cases in colorectal endoscopic submucosal dissection

scientific article published on 8 July 2013

Prevention of Indomethacin-Induced Gastric Mucosal Injury in Helicobacter pylori-Negative Healthy Volunteers: A Comparison Study Rebamipide vs Famotidine

scientific article published on July 2008

Prevention of colonic spasm using L-menthol in colonoscopic examination.

scientific article published on 2 March 2014

Preventive effect of agaro-oligosaccharides on non-steroidal anti-inflammatory drug-induced small intestinal injury in mice.

scientific article published in February 2014

Pro-oxidant action of pyrroloquinoline quinone: characterization of protein oxidative modifications

scientific article published on 7 March 2010

Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution

scientific journal article

Protective effect of serotonin derivatives on glucose-induced damage in PC12 rat pheochromocytoma cells

scientific article published on 14 September 2009

Rapamycin Improves Mortality Following Intestinal Ischemia-Reperfusion via the Inhibition of Remote Lung Inflammation in Mice.

scientific article published on 25 September 2015

Real-time monitoring of trans-epithelial electrical resistance in cultured intestinal epithelial cells: the barrier protection of water-soluble dietary fiber

scientific article published on 31 January 2017

Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity

scientific article

Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution.

scientific article

Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation.

scientific article

Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression

scientific article published in October 2005

Recognition of endoscopic diagnosis in differentiated-type early gastric cancer by flexible spectral imaging color enhancement with indigo carmine.

scientific article published on 8 August 2012

Redox biology and gastric carcinogenesis: the role of Helicobacter pylori

scientific article

Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice

scientific article published on 01 February 2011

Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer

scientific article published on 21 September 2011

Risk of lens cloudiness during colorectal endoscopic submucosal dissection and ability of a novel lens cleaner to maintain and restore endoscopic view

scientific article

Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis

scientific article published on 22 August 2008

Role of metallothionein in murine experimental colitis

scientific article published on 06 March 2013

Role of nociceptors/neuropeptides in the pathogenesis of visceral hypersensitivity of nonerosive reflux disease

scientific article published on 17 August 2012

Role of the thrombin/protease-activated receptor 1 pathway in intestinal ischemia-reperfusion injury in rats.

scientific article

Role of tumor necrosis factor-α in the pathogenesis of indomethacin-induced small intestinal injury in mice

scientific article published on 18 January 2011

Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice.

scientific article published in June 2006

Safety and Efficacy of a Same-Day Low-Volume 1 L PEG Bowel Preparation in Colonoscopy for the Elderly People and People with Renal Dysfunction.

scientific article published on 3 August 2016

Secreted Protein Acidic and Rich in Cysteine Functions in Colitis via IL17A Regulation in Mucosal CD4(+) T Cells

scientific article published on 5 June 2017

Selected reaction monitoring for colorectal cancer diagnosis using a set of five serum peptides identified by BLOTCHIP®-MS analysis

scientific article published on 01 March 2018

Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.

scientific article

Serum metabolomics analysis for early detection of colorectal cancer.

scientific article published on 20 September 2016

Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells

scientific article published on 13 November 2006

Silver nanoparticles as a safe preservative for use in cosmetics

scholarly article by Satoshi Kokura et al published August 2010 in Nanomedicine: Nanotechnology, Biology and Medicine

Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin

scientific article published on 15 September 2016

Stenotic Ischemic Enteritis with Concomitant Hepatic Portal Venous Gas and Pneumatosis Cystoides Intestinalis

scientific article published on 28 February 2018

Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency

Suppression of intestinal ischemia-reperfusion injury by a specific peroxisome proliferator-activated receptor-gamma ligand, pioglitazone, in rats

scientific article published in January 2002

Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection.

scientific article

Telomerase activity and expression of telomerase RNA component and catalytic subunits in precancerous and cancerous colorectal lesions

scientific article published on 01 November 2001

The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice

scientific article published on 10 June 2019

The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines

scientific article published on 23 January 2017

The amino acid-rich elemental diet Elental® preserves lean body mass during chemo- or chemoradiotherapy for esophageal cancer

scientific article published on 15 June 2016

The detection of surface patterns by flexible spectral imaging color enhancement without magnification for diagnosis of colorectal polyps

scientific article published on 06 December 2011

The impact of non-steroidal anti-inflammatory drugs on the small intestinal epithelium.

scientific article published on 18 December 2013

The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study.

scientific article published on 12 December 2017

The inhibitory effect of heat treatment against epithelial-mesenchymal transition (EMT) in human pancreatic adenocarcinoma cell lines

scientific article

The protective effect of orally administered redox nanoparticle on intestinal ischemia-reperfusion injury in mice.

scientific article

The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.

scientific article published on 10 August 2005

The role of mitochondria-derived reactive oxygen species in the pathogenesis of non-steroidal anti-inflammatory drug-induced small intestinal injury.

scientific article published on 21 July 2014

Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naïve ulcerative colitis.

scientific article published on October 2012

Transcriptome Analysis for Cytoprotective Actions of Rebamipide against Indomethacin-Induced Gastric Mucosal Injury in Rats.

scientific article

Transforming growth factor β1-induced collagen production in myofibroblasts is mediated by reactive oxygen species derived from NADPH oxidase 4

scientific article published on 23 October 2018

Tumor inoculation site affects the development of cancer cachexia and muscle wasting.

scientific article published on 27 May 2015

Tumor necrosis factor-alpha-induced cytokine-induced neutrophil chemoattractant-1 (CINC-1) production by rat gastric epithelial cells: role of reactive oxygen species and nuclear factor-kappaB.

scientific article published on 27 January 2004

Whole blood interferon-γ levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer

scientific article published on 29 March 2013

Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice

scientific article published in May 2007

[Capsule endoscopy]

scientific article published on 01 May 2010

alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice

scientific article published in February 2002

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