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List of works by William W Metcalf

-PcxL and HpxL are flavin-dependent, oxime-forming N-oxidases in phosphonocystoximic acid biosynthesis in Streptomyces ⬇️

scientific article published on 14 March 2018

A community resource for paired genomic and metabolomic data mining

scientific article published in 2021

A computational framework to explore large-scale biosynthetic diversity

scientific article published on 25 November 2019

A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria.

scientific article published on 25 October 2011

A roadmap for natural product discovery based on large-scale genomics and metabolomics

scientific article

An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis

scientific article

Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: an unusual way of life for a methanogenic archaeon

scientific article

Assignment of the [4Fe-4S] clusters of Ech hydrogenase from Methanosarcina barkeri to individual subunits via the characterization of site-directed mutants

scientific article

Biochemical Characterization of the Methylmercaptopropionate:Cob(I)alamin Methyltransferase from Methanosarcina acetivorans

scientific article published on 22 May 2019

Biochemical, molecular, and genetic analyses of the acetone carboxylases from Xanthobacter autotrophicus strain Py2 and Rhodobacter capsulatus strain B10.

scientific article

Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways.

scientific article published on 10 June 2008

Biosynthesis of phosphonic and phosphinic acid natural products.

scientific article published on January 2009

Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633

scientific article

Cas9-mediated genome editing in the methanogenic archaeon Methanosarcina acetivorans

scientific article published on 6 March 2017

Characterization and structure of DhpI, a phosphonateO-methyltransferase involved in dehydrophos biosynthesis

scientific article

Characterization of a Methanosarcina acetivorans mutant unable to translate UAG as pyrrolysine

scientific article published in January 2006

Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.

scientific article

Classic Spotlight: Electron Bifurcation, a Unifying Concept for Energy Conservation in Anaerobes

scientific article published on 14 April 2016

Classic Spotlight: Metabolic Flux-Which Way To Go?

scientific article published on 18 November 2016

Classic Spotlight: What's on (in) Your Plate Today?

scientific article published on 7 October 2016

Classic Spotlights: Selected Highlights from the First 100 Years of the Journal of Bacteriology

scientific article published on 13 June 2017

Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. ⬇️

scientific article published on August 2008

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

scientific article

Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria

scientific article published in January 1996

Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products.

scientific article published on 2 September 2015

Cyanohydrin phosphonate natural product from Streptomyces regensis. ⬇️

scientific article

Deciphering the late biosynthetic steps of antimalarial compound FR-900098.

scientific article

Development of a markerless genetic exchange method for Methanosarcina acetivorans C2A and its use in construction of new genetic tools for methanogenic archaea

scientific article published on March 2004

Differences in hydrogenase gene expression between Methanosarcina acetivorans and Methanosarcina barkeri

scientific article published on 06 February 2009

Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. ⬇️

scientific article

Differential regulation of the three methanol methyltransferase isozymes in Methanosarcina acetivorans C2A

scientific article

Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo

scientific article

Directed mutagenesis and plasmid-based complementation in the methanogenic archaeon Methanosarcina acetivorans C2A demonstrated by genetic analysis of proline biosynthesis

scientific article

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

scientific article published on 31 August 2015

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics. ⬇️

scientific article published on 6 March 2018

Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection.

scientific article published on 13 March 2013

Distinct regulators control the expression of methanol methyltransferase isozymes in Methanosarcina acetivorans C2A

scientific article published on 13 December 2007

Diversity and abundance of phosphonate biosynthetic genes in nature

scientific article published on 02 December 2013

Draft Genome Sequence of Methanobrevibacter smithii Isolate WWM1085, Obtained from a Human Stool Sample

scientific article published on 28 September 2017

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations. ⬇️

scientific article

Energy Conservation and Hydrogenase Function in Methanogenic Archaea, in Particular the Genus Methanosarcina

scientific article published on 18 September 2019

Energy Conservation via Hydrogen Cycling in the Methanogenic Archaeon Methanosarcina barkeri.

scientific article published on 3 July 2018

Energy conservation via hydrogen cycling in the methanogenic archaeon Methanosarcina barkeri

Fosmidomycin biosynthesis diverges from related phosphonate natural products

scientific article published on 26 August 2019

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

scientific article published on 24 February 2020

GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean

scientific article published on 07 October 2019

Genetic Methods for Methanosarcina Species

scientific article published on January 1, 2011

Genetic analysis of mch mutants in two Methanosarcina species demonstrates multiple roles for the methanopterin-dependent C-1 oxidation/reduction pathway and differences in H(2) metabolism between closely related species

scientific article

Genetic analysis of pigment biosynthesis in Xanthobacter autotrophicus Py2 using a new, highly efficient transposon mutagenesis system that is functional in a wide variety of bacteria

scientific article

Genetic analysis of the archaeon Methanosarcina barkeri Fusaro reveals a central role for Ech hydrogenase and ferredoxin in methanogenesis and carbon fixation

scientific article

Genetic analysis of the methanol- and methylamine-specific methyltransferase 2 genes of Methanosarcina acetivorans C2A

scientific article published on 28 March 2008

Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021.

scientific article

Genetic and proteomic analyses of CO utilization by Methanosarcina acetivorans

scientific article published on 07 June 2007

Genetic basis for metabolism of methylated sulfur compounds in Methanosarcina species

scientific article

Genetic, Biochemical, and Molecular Characterization of Methanosarcina barkeri Mutants Lacking Three Distinct Classes of Hydrogenase

article

Genetic, Genomic, and Transcriptomic Studies of Pyruvate Metabolism in Methanosarcina barkeri Fusaro

scientific article

Genetic, biochemical, and molecular characterization of Methanosarcina barkeri mutants lacking three distinct classes of hydrogenase

Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.

scientific article published in June 2005

Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster

scientific article published on 05 November 2020

Genome sequences of three tunicamycin-producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396.

scientific article

Genomic and phenotypic differentiation among Methanosarcina mazei populations from Columbia River sediment.

scientific article published on 10 March 2015

Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways

scientific article

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster

scientific article

Hydrogen is a preferred intermediate in the energy-conserving electron transport chain of Methanosarcina barkeri

scientific article published on September 2009

Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase

scientific article published on 17 May 2012

Isolation and biochemical characterization of hypophosphite/2-oxoglutarate dioxygenase. A novel phosphorus-oxidizing enzyme from Psuedomonas stutzeri WM88.

scientific article published on 2 August 2002

Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway

scientific article

Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer

scientific article published on 20 January 2016

Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase

scientific article published on 4 December 2009

Methylamine-specific methyltransferase paralogs in Methanosarcina are functionally distinct despite frequent gene conversion

scientific article published on 03 May 2019

Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin

scientific article published on 13 March 2019

Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster

scientific article

Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736. ⬇️

scientific article published in January 2005

Molecular genetic studies of a 10.9-kb operon inEscherichia colifor phosphonate uptake and biodegradation

scholarly article by Barry L. Wanner & William W Metcalf published December 1992 in FEMS Microbiology Letters

Mutagenesis of the C1 oxidation pathway in Methanosarcina barkeri: new insights into the Mtr/Mer bypass pathway.

scientific article

New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species.

scientific article published on December 2008

Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme

scientific article

Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis.

scientific article published on 30 December 2016

Physiology and posttranscriptional regulation of methanol:coenzyme M methyltransferase isozymes in Methanosarcina acetivorans C2A.

scientific article published on 18 September 2009

Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

scientific article published on 7 September 2017

Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

Purification and characterization of phosphonoglycans from Glycomyces sp. strain NRRL B-16210 and Stackebrandtia nassauensis NRRL B-16338.

scientific article published on 28 February 2014

Quinovosamycins: new tunicamycin-type antibiotics in which the α, β-1″,11'-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine

scientific article published on 18 May 2016

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

scientific article published on 01 January 2007

Regulation of putative methyl-sulphide methyltransferases in Methanosarcina acetivorans C2A.

scientific article published on 2 September 2009

Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways

scientific article

Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase

scientific article

Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean

scientific article

Taxonomic evaluation of species in the Streptomyces hirsutus clade using multi-locus sequence analysis and proposals to reclassify several species in this clade

scientific article

The Methanosarcina barkeri Genome: Comparative Analysis with Methanosarcina acetivorans and Methanosarcina mazei Reveals Extensive Rearrangement within Methanosarcinal Genomes

scientific article

The Methanosarcina barkeri Genome: Comparative Analysis with Methanosarcina acetivorans and Methanosarcina mazei Reveals Extensive Rearrangement within Methanosarcinal Genomes.

scientific article published in February 2007

The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica.

scientific article

The genome of M. acetivorans reveals extensive metabolic and physiological diversity

scientific article

The htx and ptx operons of Pseudomonas stutzeri WM88 are new members of the pho regulon

scientific article published on September 2004

The streptothricin acetyltransferase (sat) gene as a positive selectable marker for methanogenic archaea

scientific article published on 01 September 2019

Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation

scientific article published on 01 January 2006

Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans

scientific article

Two C-P lyase operons in Pseudomonas stutzeri and their roles in the oxidation of phosphonates, phosphite, and hypophosphite

scientific article

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.

scientific article

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster.

scientific article published on 27 December 2013

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