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List of works by Kevin W Plaxco

A Biomimetic Phosphatidylcholine-Terminated Monolayer Greatly Improves the In Vivo Performance of Electrochemical Aptamer-Based Sensors.

scientific article published on 28 March 2017

A DNA Nanodevice That Loads and Releases a Cargo with Hemoglobin-Like Allosteric Control and Cooperativity.

scientific article

A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules

scientific article published on 01 August 1997

A comparison of the folding kinetics of a small, artificially selected DNA aptamer with those of equivalently simple naturally occurring proteins

scientific article

A general electrochemical method for label-free screening of protein-small molecule interactions

scientific article

A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs.

scientific article

Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz.

scientific article

An electrochemical biosensor exploiting binding-induced changes in electron transfer of electrode-attached DNA origami to detect hundred nanometer-scale targets

scientific article published on 24 June 2020

An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe

scientific article published on October 2009

An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices.

scientific article published on May 2009

Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein

scientific article

Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides

scientific article published on January 2009

Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles

scientific article

Bioelectrochemical switches for the quantitative detection of antibodies directly in whole blood.

scientific article published on 10 September 2012

Biomimetic glass nanopores employing aptamer gates responsive to a small molecule

scientific article

Biosensors based on binding-modulated donor-acceptor distances.

scientific article

Calibration-Free Electrochemical Biosensors Supporting Accurate Molecular Measurements Directly in Undiluted Whole Blood.

scientific article published on 16 July 2017

Calibration-Free Measurement of Phenylalanine Levels in the Blood Using an Electrochemical Aptamer-Based Sensor Suitable for Point-of-Care Applications

scientific article published on 13 December 2019

Cell biology. The importance of being unfolded

scientific article published in April 1997

CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications

scientific article

Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons

scientific article published on December 2007

Collective dynamics of lysozyme in water: terahertz absorption spectroscopy and comparison with theory

scientific article

Commonly used FRET fluorophores promote collapse of an otherwise disordered protein

scientific article published on 16 April 2019

Comparing the properties of electrochemical-based DNA sensors employing different redox tags.

scientific article

Comparison of the Signaling and Stability of Electrochemical DNA Sensors Fabricated from 6- or 11-Carbon Self-Assembled Monolayers†

scientific article published on 01 December 2006

Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding.

scientific article published on July 2003

Contact order revisited: influence of protein size on the folding rate

scientific article published on September 2003

Contact order, transition state placement and the refolding rates of single domain proteins.

scientific article

Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor

scientific article

Contributions of the thymine methyl group to the specific recognition of poly- and mononucleotides: an analysis of the relative free energies of solvation of thymine and uracil.

scientific article published in March 1994

Cooperativity and the origins of rapid, single-exponential kinetics in protein folding.

scientific article published in July 2006

Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates

scientific article published in February 2003

Correction to "High-Precision Electrochemical Measurements of the Guanine-, Mismatch-, and Length-Dependence of Electron Transfer from Electrode-Bound DNA Are Consistent with a Contact-Mediated Mechanism"

scientific article published on 02 May 2019

Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor.

scientific article

Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-Modified Gold Nanoparticles ⬇️

scientific article published on November 3, 2010

Determinants of the detection limit and specificity of surface-based biosensors

scientific article published on 25 June 2013

Dielectric spectroscopy of proteins as a quantitative experimental test of computational models of their low-frequency harmonic motions

scientific article published on 20 May 2011

Electrochemical Aptamer-Based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-Controlled Drug Delivery

scientific article published on 15 October 2019

Electrochemical Biosensors Employing an Internal Electrode Attachment Site and Achieving Reversible, High Gain Detection of Specific Nucleic Acid Sequences ⬇️

scientific article published on November 28, 2011

Electrochemical DNA-Based Sensors for Molecular Quality Control: Continuous, Real-Time Melamine Detection in Flowing Whole Milk.

scientific article

Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly

scientific article

Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA

scientific article

Employing the metabolic "branch point effect" to generate an all-or-none, digital-like response in enzymatic outputs and enzyme-based sensors

scientific article published on 28 December 2011

Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors

scientific article published on January 2009

Engineering a signal transduction mechanism for protein-based biosensors.

scientific article

Engineering biosensors with extended, narrowed, or arbitrarily edited dynamic range

scientific article published on 6 February 2012

Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study.

scientific article published on 17 January 2012

Equilibrium collapse and the kinetic 'foldability' of proteins

scientific article

Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions.

scientific article

Expanding the Scope of Protein-Detecting Electrochemical DNA "Scaffold" Sensors.

scientific article

Experimental Measurement of Surface Charge Effects on the Stability of a Surface-Bound Biopolymer.

scientific article published on 18 July 2018

Exploiting binding-induced changes in probe flexibility for the optimization of electrochemical biosensors

scientific article

Fabrication of electrochemical-DNA biosensors for the reagentless detection of nucleic acids, proteins and small molecules.

scientific article

Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe.

scientific article

Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy ⬇️

scientific article published on February 27, 1998

Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.

scientific article published on April 2010

High Surface Area Electrodes Generated via Electrochemical Roughening Improve the Signaling of Electrochemical Aptamer-Based Biosensors.

scientific article published on 27 October 2017

High-Precision Electrochemical Measurements of the Guanine-, Mismatch-, and Length-Dependence of Electron Transfer from Electrode-Bound DNA Are Consistent with a Contact-Mediated Mechanism

scientific article published on 11 January 2019

High-efficiency fluorescence quenching of conjugated polymers by proteins

scientific article published in May 2002

High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks

scientific article

Improving the stability and sensing of electrochemical biosensors by employing trithiol-anchoring groups in a six-carbon self-assembled monolayer.

scientific article

Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry

scientific article

Influence of local and residual structures on the scaling behavior and dimensions of unfolded proteins

scientific article published on 01 July 2007

Investigation of an anomalously accelerating substitution in the folding of a prototypical two-state protein.

scientific article

Label-Free SERS Detection of Small Proteins Modified to Act as Bifunctional Linkers.

scientific article published on March 2008

Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor.

scientific article published in August 2005

Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates

scientific article

Limited internal friction in the rate-limiting step of a two-state protein folding reaction

scientific article published on November 1998

Linear, redox modified DNA probes as electrochemical DNA sensors.

scientific article published on 5 July 2007

Maximizing the Signal Gain of Electrochemical-DNA Sensors

scientific article

Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer efficiency

scientific article published on August 2009

Microfluidic chip-based detection and intraspecies strain discrimination of Salmonella serovars derived from whole blood of septic mice

scientific article published on 25 January 2013

Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences

scientific article published on 9 January 2008

New Architecture for Reagentless, Protein-Based Electrochemical Biosensors.

scientific article published on 8 August 2017

Non-sequence-specific interactions can account for the compaction of proteins unfolded under "native" conditions.

scientific article published on 12 September 2009

Nonglassy kinetics in the folding of a simple single-domain protein.

scientific article

On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms

scientific article published on June 2009

On the precision of experimentally determined protein folding rates and phi-values

scientific article

Open Source Software for the Real-Time Control, Processing, and Visualization of High-Volume Electrochemical Data

scientific article published on 10 September 2019

Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry

scientific article published on 9 August 2008

Peptide beacons: a new design for polypeptide-based optical biosensors.

scientific article published on 27 April 2007

Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches

scientific article published on 4 October 2011

Probe accessibility effects on the performance of electrochemical biosensors employing DNA monolayers

scientific article published on 19 September 2011

Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy.

scientific article

Protein complexes: the evolution of symmetry.

scientific article published on January 2009

Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins

scientific article

Quantification of transcription factor binding in cell extracts using an electrochemical, structure-switching biosensor.

scientific article published on 10 February 2012

Quantitative measurements of protein-surface interaction thermodynamics

article published in the Proceedings of the National Academy of Sciences of the United States of America

Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum

scientific article

Random-coil behavior and the dimensions of chemically unfolded proteins

scholarly article

Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care through microfluidic electrochemical quantitative loop-mediated isothermal amplification

scientific article

Rational design of allosteric inhibitors and activators using the population-shift model: in vitro validation and application to an artificial biosensor

scientific article published on 5 September 2012

Rational design to control the trade-off between receptor affinity and cooperativity

scientific article published on 29 July 2020

Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors.

scientific article

Reagentless Measurement of Aminoglycoside Antibiotics in Blood Serum via an Electrochemical, Ribonucleic Acid Aptamer-Based Biosensor ⬇️

scientific article published on September 1, 2010

Real-time, aptamer-based tracking of circulating therapeutic agents in living animals

scientific article

Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation

scientific article published in February 2002

Re‐engineering Electrochemical Biosensors To Narrow or Extend Their Useful Dynamic Range ⬇️

scientific article published on June 5, 2012

Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in situ in the living body

scientific article published on 22 July 2019

Sensitive and selective amplified fluorescence DNA detection based on exonuclease III-aided target recycling.

scientific article published in February 2010

Sequence and temperature dependence of the end-to-end collision dynamics of single-stranded DNA

scientific article published on June 2013

Simplified proteins: minimalist solutions to the 'protein folding problem'.

scientific article

Simulation-Based Approach to Determining Electron Transfer Rates Using Square-Wave Voltammetry.

scientific article published on 9 April 2017

Small-Angle X-ray Scattering and Single-Molecule FRET Spectroscopy Produce Highly Divergent Views of the Low-Denaturant Unfolded State ⬇️

scientific article published on January 27, 2012

Some recommendations for the practitioner to improve the precision of experimentally determined protein folding rates and phi values

scientific article published on February 2009

Structure-switching biosensors: inspired by Nature.

scientific article published on 02 June 2010

Subsecond-Resolved Molecular Measurements in the Living Body Using Chronoamperometrically Interrogated Aptamer-Based Sensors

scientific article

Surface Attachment Enhances the Thermodynamic Stability of Protein L

scientific article published on 15 January 2019

Surface chemistry effects on the performance of an electrochemical DNA sensor

scientific article published on 20 March 2009

Switch-based biosensors: a new approach towards real-time, in vivo molecular detection

scientific article published on 23 November 2010

Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery.

scientific article published in January 2003

The art of writing science ⬇️

scientific article published on December 1, 2010

The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG

scientific article published on 01 October 1997

The folding kinetics and thermodynamics of the Fyn-SH3 domain.

scientific article

The length and viscosity dependence of end-to-end collision rates in single-stranded DNA

scientific article published on July 2009

The protein folding transition state: what are Phi-values really telling us?

scientific article

The rate of intramolecular loop formation in DNA and polypeptides: the absence of the diffusion-controlled limit and fractional power-law viscosity dependence

scientific article published on October 2009

Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches

scientific article

Time-resolved biophysical methods in the study of protein folding

scientific article published on October 1996

Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins

scientific article

Tracking a molecular motor with a nanoscale optical encoder

scientific article

Transcription factor beacons for the quantitative detection of DNA binding activity

scientific article published on 12 August 2011

Two‐Step, PCR‐Free Telomerase Detection by Using Exonuclease III‐Aided Target Recycling ⬇️

scientific article published on November 28, 2011

Unfolded, yes, but random? Never!

scientific article published on 01 August 2001

Universality in the Timescales of Internal Loop Formation in Unfolded Proteins and Single-Stranded Oligonucleotides ⬇️

scientific article published on December 15, 2010

Using distal-site mutations and allosteric inhibition to tune, extend, and narrow the useful dynamic range of aptamer-based sensors.

scientific article published on 13 December 2012

Using protein folding rates to test protein folding theories.

scientific article published on January 2004

Using triplex-forming oligonucleotide probes for the reagentless, electrochemical detection of double-stranded DNA.

scientific article published on 11 October 2010

Wash-free, electrochemical platform for the quantitative, multiplexed detection of specific antibodies

scientific article

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