List of works - Paul Digard

'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs

scientific article

A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability

scientific article published on February 2014

A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA

scientific article

A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance

scientific article

A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA.

scientific article published on 03 June 2009

A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions

scientific article published on September 2002

A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant

scientific article

A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein

scientific article published on October 1990

A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture

scientific article published on 14 May 2012

Accessory Gene Products of Influenza A Virus

scientific article published on 28 September 2020

Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA.

scientific article

An analysis of the biological properties of monoclonal antibodies against glycoprotein D of herpes simplex virus and identification of amino acid substitutions that confer resistance to neutralization

scientific article published in June 1986

An overlapping protein-coding region in influenza A virus segment 3 modulates the host response

scientific article published on 28 June 2012

Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication

scientific article published on 08 October 2019

Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway

scientific article

Characterisation of influenza A viruses with mutations in segment 5 packaging signals

scientific article published on October 2009

Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot

scientific article

Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins

scientific article published on 28 December 2015

Codon conservation in the influenza A virus genome defines RNA packaging signals

scientific article

Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes

scientific article

Comprehensive characterisation of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences

scientific article published on 11 March 2020

Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses

scientific article published on 29 July 2020

Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase

scientific article

Detection of influenza C virus but not influenza D virus in Scottish respiratory samples

scientific article

Dynamics of influenza virus infection and pathology.

scientific article

Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1.

scientific article

Effects of mutations in the effector domain of influenza A virus NS1 protein

scientific article published on 18 September 2018

Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza

scientific article published on 03 March 2020

Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain

scientific article published on 23 October 2007

Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus

scientific article published on 5 September 2012

Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation

scientific article (publication date: 2013)

Functional analysis of the herpes simplex virus UL42 protein.

scientific article published on March 1993

Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites

scientific article published in March 2004

Genome packaging in influenza A virus

scientific article published on 02 December 2009

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

scientific article published on 09 January 2020

Human cytomegalovirus inhibitor AL18 also possesses activity against influenza A and B viruses

scientific article published on 20 August 2012

Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis

scientific article

IFITM3 restricts the morbidity and mortality associated with influenza

scientific article

Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain

scientific article (publication date: 2012)

Identification of amino acid residues of influenza virus nucleoprotein essential for RNA binding.

scientific article published on September 1999

Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virions

scientific article

Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication

scientific article

Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export

scientific article

Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

scientific article

Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA.

scientific article

Influenza A virus and the cell nucleus

scientific article published on 9 June 2006

Influenza--time to target the host?

scientific article published on July 2013

Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB2 subunit

scientific article published in May 1996

Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway

scientific article published on January 2001

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis

scientific article published on 29 October 2014

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

scientific article published on 10 May 2020

Lipid raft-dependent targeting of the influenza A virus nucleoprotein to the apical plasma membrane

scientific article published in December 2004

Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments.

scientific article published on March 1999

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

scholarly article by Saira Hussain et al published 31 October 2018 in Journal of Virology

Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype

scientific article published in January 1995

Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus

scientific article published on 24 September 2008

Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies

scientific article

Nuclear export of influenza A virus mRNAs requires ongoing RNA polymerase II activity

scientific article published on 21 November 2006

Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection

scientific article published on 13 February 2013

Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements

scientific article published on July 1999

Overlapping signals for translational regulation and packaging of influenza A virus segment 2

scientific article

Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules

scientific article published on 29 June 2011

Permissive and restricted virus infection of murine embryonic stem cells

scientific article published on 18 July 2012

Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site

scientific article published on September 1991

Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells

scientific article published on October 2010

Release of filamentous and spherical influenza A virus is not restricted by tetherin

scientific article published on 18 January 2012

Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction

scientific article

Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

scientific article

Role of the Rab11 pathway in negative-strand virus assembly

scientific article published on December 2012

Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase

scientific article published in January 2000

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

scientific article

Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface

scientific article

Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication

scientific article published on 07 July 2020

Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions

scientific article

Survival of influenza A(H1N1) on materials found in households: implications for infection control

scientific article (publication date: 2011)

Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

scientific article

The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase

scientific article

The Rab11 pathway is required for influenza A virus budding and filament formation

scientific article

The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: Implications for infection prevention and control

scientific article published on December 2015

The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.

scientific article published on January 1993

The genetics of virus particle shape in equine influenza A virus

scientific article published on December 2013

The influence of viral coding sequences on pestivirus IRES activity reveals further parallels with translation initiation in prokaryotes.

scientific article

The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

scientific article

Unusual regulation of expression of the herpes simplex virus DNA polymerase gene

scientific article published on September 1993

Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes

scientific article published on 19 January 2012

List of works by Paul Digard

'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs

A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability

A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA

A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance

A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA.

A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions

A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant

A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein

A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture

Accessory Gene Products of Influenza A Virus

Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA.

An analysis of the biological properties of monoclonal antibodies against glycoprotein D of herpes simplex virus and identification of amino acid substitutions that confer resistance to neutralization

An overlapping protein-coding region in influenza A virus segment 3 modulates the host response

Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication

Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway

Characterisation of influenza A viruses with mutations in segment 5 packaging signals

Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot

Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins

Codon conservation in the influenza A virus genome defines RNA packaging signals

Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes

Comprehensive characterisation of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences

Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses

Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase

Detection of influenza C virus but not influenza D virus in Scottish respiratory samples

Dynamics of influenza virus infection and pathology.

Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1.

Effects of mutations in the effector domain of influenza A virus NS1 protein

Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza

Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain

Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus

Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation

Functional analysis of the herpes simplex virus UL42 protein.

Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites

Genome packaging in influenza A virus

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Human cytomegalovirus inhibitor AL18 also possesses activity against influenza A and B viruses

Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis

IFITM3 restricts the morbidity and mortality associated with influenza

Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain

Identification of amino acid residues of influenza virus nucleoprotein essential for RNA binding.

Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virions

Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication

Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export

Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA.

Influenza A virus and the cell nucleus

Influenza--time to target the host?

Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB2 subunit

Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

Lipid raft-dependent targeting of the influenza A virus nucleoprotein to the apical plasma membrane

Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments.

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype

Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus

Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies

Nuclear export of influenza A virus mRNAs requires ongoing RNA polymerase II activity

Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection

Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements

Overlapping signals for translational regulation and packaging of influenza A virus segment 2

Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules

Permissive and restricted virus infection of murine embryonic stem cells

Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site

Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells

Release of filamentous and spherical influenza A virus is not restricted by tetherin

Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction

Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

Role of the Rab11 pathway in negative-strand virus assembly

Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface

Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication

Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions

Survival of influenza A(H1N1) on materials found in households: implications for infection control

Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase

The Rab11 pathway is required for influenza A virus budding and filament formation

The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: Implications for infection prevention and control