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List of works by Michael P. Hay

18F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model ⬇️

scientific article published on 05 June 2013

4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.

scientific article

A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.

scientific article published on August 1999

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

scientific article

Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction

scientific article published in January 2003

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

scientific article published on 10 July 2019

Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects

scientific article published on 19 August 2018

Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro

scientific article

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

scientific article published on 16 April 2014

Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

scientific article published in March 2010

Chemical Space Mimicry for Drug Discovery

scientific article

Complete 1H, 13C and 15N NMR assignment of tirapazamine and related 1,2,4-benzotriazine N-oxides

scientific article published on 01 October 2006

DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine

scientific article published on January 2004

Dynamin impacts homology-directed repair and breast cancer response to chemotherapy

scientific article published on 29 October 2018

Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers.

scientific article published on January 2016

Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine

scientific article published in November 2003

Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures

scientific article published in February 2005

Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction

scientific article published on 01 November 2014

Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.

scientific article published on 13 December 2011

Hypoxia-Activated Prodrugs of PERK Inhibitors

scientific article published on 29 January 2019

Hypoxia-directed drug strategies to target the tumor microenvironment

scientific article published on January 2014

Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity

scientific article published on 6 December 2007

Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.

scientific article published on May 1995

Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers.

scientific article published on February 1994

Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361

scientific article published on 18 September 2019

Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents

scientific article published on 20 December 2013

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

scientific article

Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy

scientific article

Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers

scientific article published on 3 March 2014

Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs

scientific article published on 08 March 2019

Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides

scientific article

Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer

scientific article published on 12 December 2020

Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport

scientific article published on 15 November 2007

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors

scientific article

Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solution

scientific article published on 11 September 2014

Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria

scientific article published in January 2006

Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides

scientific article

Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.

scientific article

Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia

scientific article published on 17 September 2019

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

scientific article published on 11 August 2017

SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells

scientific article published on 24 April 2011

Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.

scientific article published on January 2004

Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase

scientific article published in October 2009

Stille coupling reactions in the synthesis of hypoxia-selective 3-alkyl-1,2,4-benzotriazine 1,4-dioxide anticancer agents

scientific article published on 01 August 2006

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase

scientific article published on June 2003

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine

scientific article

Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors

scientific article published on 19 April 2019

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

scientific article published on 22 October 2020

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy

scientific article published on December 2003

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality ⬇️

scientific article published on August 3, 2011

Targeting growth hormone function: strategies and therapeutic applications

scientific article published on 08 February 2019

Targeting hypoxia in cancer therapy

scientific article (publication date: June 2011)

The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.

scientific article

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

scientific article

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs

scientific article published on 01 August 2006

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