List of works - Mustapha Si-Tahar

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

scientific article

Adhesion molecules expressed on homing lymphocytes in model intestinal epithelia

scientific article

Aerosol Route to Administer Teicoplanin in Mechanical Ventilation: In Vitro Study, Lung Deposition and Pharmacokinetic Analyses in Pigs

scientific article published on 23 January 2015

Altered expression of the CCN genes in the lungs of mice in response to cigarette smoke exposure and viral and bacterial infections.

scientific article

Ambivalent role of the innate immune response in rabies virus pathogenesis

scientific article

Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.

scientific article

Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules

scientific article published in June 2001

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

scientific article published on 21 July 2016

Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets

scientific article published on 23 November 2015

Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells

scientific article (publication date: June 2000)

Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin

scientific article published on July 2008

Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells

scientific article

Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway.

scientific article published on February 2008

Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4

scientific article published on 01 June 2002

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia

scientific article

Differential interaction of bacterial species from the Burkholderia cepacia complex with human airway epithelial cells

scientific article published on 9 October 2007

Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.

scientific article published on 26 May 2010

Effect of formulation on the stability and aerosol performance of a nebulized antibody

scientific article published on 30 October 2014

FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection

scientific article published on 13 February 2017

Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections

scientific article published on 30 March 2016

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

scientific article published on 5 August 2016

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells

scientific article published on 26 May 2008

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

scientific article

Innate immunity and inflammation--two facets of the same anti-infectious reaction.

scientific article published on 02 March 2009

Innate sensing of HIV-infected cells

scientific article

Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages

scientific article published on 31 January 2012

Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis

scientific article published on 04 February 2016

Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

scientific article published on 17 April 2013

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.

scientific article published in September 2005

Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

scientific article published on 3 December 2004

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

scientific article published on 14 June 2017

LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis

scientific article published on 17 June 2013

Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia

scientific article published on 17 June 2009

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells

scientific article

Modulation by superoxide anions of neutrophil-mediated platelet activation

scientific article published on 01 April 1994

Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence

scientific article

Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6

scientific article

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

scientific article published on 16 February 2016

Neutrophils can disarm NK cell response through cleavage of NKp46.

scientific article published in September 2016

Phosphoinositide 3-kinase inhibition reverses platelet aggregation triggered by the combination of the neutrophil proteinases elastase and cathepsin G without impairing alpha(IIb)beta(3) integrin activation

scientific article published on 01 November 2000

Poly-L-Lysine compacts DNA, kills bacteria, and improves protease inhibition in cystic fibrosis sputum

scientific article published in September 2013

Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia

scientific article published on 13 April 2011

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

scientific article published on 11 February 2017

Protective role of LGP2 in influenza virus pathogenesis.

scientific article published on 3 February 2014

Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation

scientific article

Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis

scientific article published on 01 January 2018

Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.

scientific article

Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.

scientific article published on 4 November 2003

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

scientific article

TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia.

scientific article published in August 2008

TLRs 2 and 4 are not involved in hypersusceptibility to acute Pseudomonas aeruginosa lung infections

scientific article published on 01 September 2005

Targeting host calpain proteases decreases influenza A virus infection.

scientific article

Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

scientific article published on 12 October 2017

The CC chemokines MDC and TARC induce platelet activation via CCR4

scientific article (publication date: 15 February 2001)

The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases.

scientific article

The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa

scientific article published on 11 June 2007

hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions

scientific article

List of works by Mustapha Si-Tahar

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

Adhesion molecules expressed on homing lymphocytes in model intestinal epithelia

Aerosol Route to Administer Teicoplanin in Mechanical Ventilation: In Vitro Study, Lung Deposition and Pharmacokinetic Analyses in Pigs

Altered expression of the CCN genes in the lungs of mice in response to cigarette smoke exposure and viral and bacterial infections.

Ambivalent role of the innate immune response in rabies virus pathogenesis

Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.

Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets

Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells

Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin

Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells

Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway.

Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia

Differential interaction of bacterial species from the Burkholderia cepacia complex with human airway epithelial cells

Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.

Effect of formulation on the stability and aerosol performance of a nebulized antibody

FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection

Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

Innate immunity and inflammation--two facets of the same anti-infectious reaction.

Innate sensing of HIV-infected cells

Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages

Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis

Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.

Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis

Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells

Modulation by superoxide anions of neutrophil-mediated platelet activation

Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence

Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Neutrophils can disarm NK cell response through cleavage of NKp46.

Phosphoinositide 3-kinase inhibition reverses platelet aggregation triggered by the combination of the neutrophil proteinases elastase and cathepsin G without impairing alpha(IIb)beta(3) integrin activation

Poly-L-Lysine compacts DNA, kills bacteria, and improves protease inhibition in cystic fibrosis sputum

Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

Protective role of LGP2 in influenza virus pathogenesis.

Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation

Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis

Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.

Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia.

TLRs 2 and 4 are not involved in hypersusceptibility to acute Pseudomonas aeruginosa lung infections

Targeting host calpain proteases decreases influenza A virus infection.

Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

The CC chemokines MDC and TARC induce platelet activation via CCR4

The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases.

The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa

hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions