List of works by Giacomo Parigi

"Four-dimensional" protein structures: examples from metalloproteins.

scientific article

(1)H and (13)C dynamic nuclear polarization in aqueous solution with a two-field (0.35 T/14 T) shuttle DNP spectrometer

scientific article published in October 2009

13C Direct Detected NMR Increases the Detectability of Residual Dipolar Couplings

scientific article published on 01 November 2006

1H NMRD Profiles of Paramagnetic Complexes and Metalloproteins

1H nuclear magnetic relaxation dispersion of Cu,Zn superoxide dismutase in the native and guanidinium-induced unfolded forms

scientific article

A critical assessment of methods to recover information from averaged data

scientific article

A modular system for the synthesis of multiplexed magnetic resonance probes.

scientific article

Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples

scientific article

Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent

scientific article

Application of NMRD to hydration of rubredoxin and a variant containing a (Cys-S)3FeIII(OH) site

scientific article

Assessing protein conformational landscapes: integration of DEER data in Maximum Occurrence analysis

Backbone-Only Protein Solution Structures with a Combination of Classical and Paramagnetism-Based Constraints: A Method that Can Be Scaled to Large Molecules

scientific article published on 01 June 2004

Basic facts and perspectives of Overhauser DNP NMR.

scientific article

Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging

scientific article published on 04 April 2019

Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity

scientific article published on 21 February 2011

Can metal ion complexes be used as polarizing agents for solution DNP? A theoretical discussion

scientific article published on 20 April 2013

Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics

scientific article published on 09 January 2019

ChemInform Abstract: NMR Crystallography on Paramagnetic Systems. Solved and Open Issues

scholarly article by Anusarka Bhaumik et al published 31 January 2014 in ChemInform

Collective relaxation of protein protons at very low magnetic field: a new window on protein dynamics and aggregation.

scientific article published in February 2007

Combining in silico tools and NMR data to validate protein-ligand structural models: application to matrix metalloproteinases

scientific article

Conformational freedom of metalloproteins revealed by paramagnetism-assisted NMR

Conformational space of flexible biological macromolecules from average data

scientific article

Correction to Gd(III)-Labeled Peptide Nanofibers for Reporting on Biomaterial Localization in Vivo

scientific article published on 30 October 2015

Correction to: Joint X-ray/NMR structure refinement of multidomain/multisubunit systems

scientific article published on 01 July 2019

Cross correlation between the dipole-dipole interaction and the Curie spin relaxation: the effect of anisotropic magnetic susceptibility.

scientific article published in September 2001

Differences in Dynamics between Crosslinked and Non-Crosslinked Hyaluronates Measured by using Fast Field-Cycling Relaxometry

scientific article

Dynamic nuclear polarization at high magnetic fields in liquids.

scientific article

Effect of Magnetic Coupling on Water Proton Relaxivity in a Series of Transition Metal GdIII Complexes.

scientific article

Efficiency of paramagnetism-based constraints to determine the spatial arrangement of alpha-helical secondary structure elements.

scientific article published in February 2002

Efficient determination of the most favoured orientations of protein domains from paramagnetic NMR data

Electron relaxation and solvent accessibility of the metal site in wild-type and mutated azurins as determined from nuclear magnetic relaxation dispersion experiments

Enriching the biological space of natural products and charting drug metabolites, through real time biotransformation monitoring: The NMR tube bioreactor

scientific article published on 30 September 2017

Erratum: Paramagnetism-based restraints for Xplor-NIH

scientific article published on 01 June 2004

Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.

scientific article published on 11 September 2013

Experimental Determination of Microsecond Reorientation Correlation Times in Protein Solutions

Experimental NMRD Profiles for Some Low-Symmetry Ni(II) Complexes (S= 1) in Solution and Their Interpretation Using Slow-Motion Theory

Experimentally exploring the conformational space sampled by domain reorientation in calmodulin

scientific article

Exploring regions of conformational space occupied by two-domain proteins.

scientific article published on 27 August 2014

Extensive NMRD studies of Ni(II) salt solutions in water and water-glycerol mixtures

scientific article

FANTEN: a new web-based interface for the analysis of magnetic anisotropy-induced NMR data.

scientific article

Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy

scientific article

Field dependent dynamic nuclear polarization with radicals in aqueous solution

scientific article

Gd(III)-labeled peptide nanofibers for reporting on biomaterial localization in vivo

scientific article

Global and local mobility of apocalmodulin monitored through fast-field cycling relaxometry

scientific article published on September 2009

Heme methyl 1H chemical shifts as structural parameters in some low-spin ferriheme proteins.

scientific article published in August 1999

High relaxivity Gd(III)-DNA gold nanostars: investigation of shape effects on proton relaxation

scientific article

High-field liquid state NMR hyperpolarization: a combined DNP/NMRD approach

scientific article

Hints on experimental techniques

How Do Nuclei Couple to the Magnetic Moment of a Paramagnetic Center? A New Theory at the Gauntlet of the Experiments

scientific article published on 15 June 2019

How to tackle protein structural data from solution and solid state: An integrated approach

scientific article

Human multiprotein bridging factor 1 and Calmodulin do not interact in vitro as confirmed by NMR spectroscopy and CaM-agarose affinity chromatography.

scientific article

Hyperfine Shifts in Low-Spin Iron(III) Hemes: A Ligand Field Analysis

Identification of productive and futile encounters in an electron transfer protein complex.

scientific article published on 21 February 2017

Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure

scientific article

Information content of long-range NMR data for the characterization of conformational heterogeneity.

scientific article

Insights into domain-domain motions in proteins and RNA from solution NMR

scientific article

Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations

scientific article published in February 2016

Joint X-ray/NMR structure refinement of multidomain/multisubunit systems

article published in 2018

Liquid state DNP of water at 9.2 T: an experimental access to saturation

scientific article

Local and Global Dynamics in Intrinsically Disordered Synuclein

scholarly article by Nasrollah Rezaei-Ghaleh et al published 18 October 2018 in Angewandte Chemie International Edition

Lokale und globale Dynamik im ungeordneten Synuklein-Protein

Long-Range Correlated Dynamics in Intrinsically Disordered Proteins

article

Long-range paramagnetic NMR data can provide a closer look on metal coordination in metalloproteins.

scientific article published on 7 December 2017

Magnetic Susceptibility in Paramagnetic NMR

Magnetic susceptibility and paramagnetism-based NMR

scientific article published on 22 June 2019

MaxOcc: a web portal for maximum occurrence analysis

scientific article published on 26 May 2012

Maximum occurrence analysis of protein conformations for different distributions of paramagnetic metal ions within flexible two-domain proteins

scientific article published on 30 December 2011

Mechanisms of Gadographene-Mediated Proton Spin Relaxation

scientific article

Mechanistic Insights into Polyion Complex Associations

Mechanistic investigation of beta-galactosidase-activated MR contrast agents.

scientific article

Mechanistic studies of a calcium-dependent MRI contrast agent

scientific article

Metal centers in biomolecular solid-state NMR

scientific article published on 28 November 2018

Microcrystalline Proteins - An Ideal Benchmark for Methodology Development

article

Moving the frontiers in solution and solid-state bioNMR

NMR Spectroscopic Detection of Protein Protons and Longitudinal Relaxation Rates between 0.01 and 50 MHz

scientific article published on 01 April 2005

NMR Spectroscopic Detection of Protein Protons and Longitudinal Relaxation Rates between 0.01 and 50 MHz

NMR Spectroscopy and Metal Ions in Life Sciences

NMR crystallography on paramagnetic systems: solved and open issues

scholarly article by Anusarka Bhaumik et al published 2013 in CrystEngComm

NMR of sedimented, fibrillized, silica-entrapped and microcrystalline (metallo)proteins

scientific article

NMR properties of sedimented solutes

NMR spectroscopy of paramagnetic metalloproteins

scientific article

NMR-validated structural model for oxidized Rhodopseudomonas palustris cytochrome c(556)

scientific article

NMRD studies on phthalate dioxygenase: evidence for displacement of water on binding substrate

Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High Field

scientific article

Narrowing the conformational space sampled by two-domain proteins with paramagnetic probes in both domains

scientific article published on 9 August 2011

Neue Ansätze zur Empfindlichkeitssteigerung in der biomolekularen NMR-Spektroskopie

article

Nuclear Spin Relaxation in Paramagnetic Systems: Electron Spin Relaxation Effects under Near-Redfield Limit Conditions and Beyond

Nuclear and Electron Relaxation in Magnetic Exchange Coupled Dimers: Implications for NMR Spectroscopy

scientific article published in January 1998

Nuclear spin relaxation in paramagnetic complexes of S=1: Electron spin relaxation effects

Off-resonance experiments and contrast agents to improve magnetic resonance imaging

scientific article

One-thousand-fold enhancement of high field liquid nuclear magnetic resonance signals at room temperature ⬇️

scientific article (publication date: 13 February 2017)

Overhauser DNP with 15N labelled Frémy's salt at 0.35 Tesla

scientific article

Pairwise binding competition experiments for sorting hub-protein/effector interaction hierarchy and simultaneous equilibria

article

Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding

scientific article published on 03 July 2018

Paramagnetic Molecules

article published in 2012

Paramagnetic Properties of a Crystalline Iron-Sulfur Protein by Magic-Angle Spinning NMR Spectroscopy

scientific article

Paramagnetic Systems in Biochemistry: Solution NMR Studies

Paramagnetic constraints: An aid for quick solution structure determination of paramagnetic metalloproteins

Paramagnetic relaxation enhancement for the characterization of the conformational heterogeneity in two-domain proteins

scientific article

Paramagnetism-Based Restraints for Xplor-NIH

scientific article published on 01 March 2004

Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains.

scientific article published on 2 October 2007

Paramagnetism-based versus classical constraints: an analysis of the solution structure of Ca Ln calbindin D9k

scientific article

Partial Orientation of Cytochromecin a Lyotropic Liquid Crystal: Residual H−H Dipolar Coupling

Perspectives in paramagnetic NMR of metalloproteins

article

Perspectives on paramagnetic NMR from a life sciences infrastructure

scientific article

Practical considerations over spectral quality in solid state NMR spectroscopy of soluble proteins

scientific article published on 30 August 2013

Pseudo-Contact NMR Shifts over the Paramagnetic Metalloprotein CoMMP-12 from First Principles

scientific article published on 26 October 2016

Pseudocontact shifts and paramagnetic susceptibility in semiempirical and quantum chemistry theories

scientific article published on 01 April 2019

Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex

scientific article published in March 2012

Relaxivity of Gd-Based MRI Contrast Agents in Crosslinked Hyaluronic Acid as a Model for Tissues

scientific article published on 30 July 2019

Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation

scientific article published on 06 June 2019

SedNMR: on the edge between solution and solid-state NMR.

scientific article

Simultaneous use of solution NMR and X-ray data in REFMAC5 for joint refinement/detection of structural differences

scientific article

Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity

scientific article published on 04 May 2020

Solid-State NMR Crystallography through Paramagnetic Restraints

scientific article published on 08 March 2012

Solid-state NMR of proteins sedimented by ultracentrifugation

scientific article

Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states

scientific article

Solvent (1)H NMRD study of hexaaquochromium(III): inferences on hydration and electron relaxation

scientific article

Solvent 1H NMRD study of biotinylated paramagnetic liposomes containing Gd-bis-SDA-DTPA or Gd-DMPE-DTPA

Structural characterization of human S100A16, a low-affinity calcium binder

scientific article

Sulfonamide-Functionalized Gadolinium DTPA Complexes as Possible Contrast Agents for MRI: A Relaxometric Investigation

Sulfonamide-Functionalized Gadolinium DTPA Complexes as Possible Contrast Agents for MRI: A Relaxometric Investigation

The Photocatalyzed Thiol-ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins

scientific article published on 24 February 2020

The catalytic domain of MMP-1 studied through tagged lanthanides

scientific article

The competitive world of RAS biology

scientific article published on 01 March 2014

The effect of Gd on trityl-based dynamic nuclear polarisation in solids

scientific article

The synthesis and in vitro testing of a zinc-activated MRI contrast agent

scientific article

Towards a Protocol for Solution Structure Determination of Copper(II) Proteins: the Case of CuIIZnII Superoxide Dismutase

scholarly article by Ivano Bertini published in August 2007

Understanding Overhauser Dynamic Nuclear Polarisation through NMR relaxometry

scholarly article by Giacomo Parigi published in September 2018

Water 1H relaxation dispersion analysis on a nitroxide radical provides information on the maximal signal enhancement in Overhauser dynamic nuclear polarization experiments

scientific article

Water and protein dynamics in sedimented systems: a relaxometric investigation

scientific article

What are the methodological and theoretical prospects for paramagnetic NMR in structural biology? A glimpse into the crystal ball

scientific article published on 11 July 2019

“Four-Dimensional” Protein Structures: Examples from Metalloproteins

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