List of works - Daniele Passarella

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

scientific article

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II.

scientific article

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

scientific article published on 13 May 2013

A convenient synthesis of delta(7,8)-morphinan-6-one and its direct oxidation to 14-hydroxy-delta(7,8)-morphinan-6-one

scientific article

A highly enantioselective synthesis of (−)-antirhine by chemo-enzymatic approach

article published in 1994

A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition

scientific article published on 16 July 2020

Access to Pyrrolo- and Pyrido[1,2-a]indole Derivatives by Intramolecular Nitrone Cycloadditions. Effect of Steric Factors on the Regioselective Product Formation

scientific article published on 01 December 2000

An efficient chemo-enzymatic approach to (+)-meroquinene

Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. ⬇️

scientific article

Aspidosperma alkaloids cyclization of secodine intermediate: Synthesis of (±)-3-oxovincadifformine ethyl ester

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

scientific article published on 20 January 2015

Bruno Danieli (1939–2014).

scientific article published on 29 December 2015

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

scientific article

Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?

Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization

scientific article published on 29 September 2020

Catalytic C3 aza-alkylation of indoles

scientific article published on 28 July 2020

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

scientific article

Chemical approaches to targeting drug resistance in cancer stem cells.

scientific article published on 10 May 2014

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

scientific article published on 08 February 2012

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

scientific article

Combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures

scientific article

Comparative phytochemical and morphological analyses of three Italian Primula species

scientific article published on 4 June 2007

Concise total synthesis of (+/-)-aloperine and 6-epi-aloperine

scientific article published on 01 August 2002

Covalent Nucleoside Adducts of Aspidosperma Alkaloids

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

scientific article published on May 2014

Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation

scientific article

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

scientific article published on 11 July 2020

Enantiopure 2-piperidylacetaldehyde as a useful building block in the diversity-oriented synthesis of polycyclic piperidine derivatives

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

scientific article

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

scientific article published on 30 September 2010

Farinose alpine Primula species: phytochemical and morphological investigations.

scientific article

Functionalization at C-17 of an Eburnea-Aspidosperma Binary Alkaloid as a Model to Study Modified Vinblastine-type Antitumor Alkaloids

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

scientific article published on 30 September 2009

Histone demethylating agents as potential S-adenosyl-l-methionine-competitors

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

scientific article published on 01 March 2003

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling ⬇️

scientific article published on November 4, 2011

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

scientific article

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

scientific article published on 30 August 2011

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

scientific article published on 20 August 2019

Natural Products and Cancer Stem Cells.

scientific article published on 02 October 2015

Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine

scientific article published on 01 July 2006

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

scientific article

New flavonol glycosides from Aconitum burnatii Gáyer and Aconitum variegatum L.

scientific article published on 20 June 2010

Novel chemical probes for the investigation of nonribosomal peptide assembly.

scientific article

Preparation of Fluorescent Tubulin Binders

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

scientific article

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

scientific article published on 19 September 2013

Remote stereocenter discrimination in the enzymatic resolution of piperidine-2-ethanol. Short enantioselective synthesis of sedamine and allosedamine.

scientific article published in November 2003

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

scientific article published on 17 January 2017

Self-assembly drug conjugates for anticancer treatment

scientific article published on 18 June 2016

Synthesis and biological evaluation of epothilone A dimeric compounds.

scientific article published on 20 September 2009

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

scientific article published on 25 January 2011

Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

scientific article published on 7 October 2010

Synthesis and biological evaluation of novel tamoxifen analogues

scientific article published on 15 May 2013

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

scientific article published on 6 October 2009

Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids

scientific article published on February 2004

Synthesis and biological evaluation of pyrroloiminoquinone derivatives

scientific article published on 28 November 2007

Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies

scientific article published on 19 April 2011

Synthesis of Pironetin-Dumetorine Hybrids as Tubulin Binders

article published in 2016

Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders

scientific article published on 01 January 2019

Synthetic studies on indole alxaloids. A stereocontrolled entry to the cuanzine structural unit

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

scientific article published in March 2006

Tools for the rational design of bivalent microtubule-targeting drugs.

scientific article published on 6 September 2016

Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach

scientific article published on 27 February 2020

Total enantioselective synthesis of (-)-cytisine

scientific article published on 01 February 2004

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines

scientific article published on 01 April 2002

List of works by Daniele Passarella

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II.

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

A convenient synthesis of delta(7,8)-morphinan-6-one and its direct oxidation to 14-hydroxy-delta(7,8)-morphinan-6-one

A highly enantioselective synthesis of (−)-antirhine by chemo-enzymatic approach

A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition

Access to Pyrrolo- and Pyrido[1,2-a]indole Derivatives by Intramolecular Nitrone Cycloadditions. Effect of Steric Factors on the Regioselective Product Formation

An efficient chemo-enzymatic approach to (+)-meroquinene

Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. ⬇️

Aspidosperma alkaloids cyclization of secodine intermediate: Synthesis of (±)-3-oxovincadifformine ethyl ester

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

Bruno Danieli (1939–2014).

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?

Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization

Catalytic C3 aza-alkylation of indoles

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

Chemical approaches to targeting drug resistance in cancer stem cells.

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

Combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures

Comparative phytochemical and morphological analyses of three Italian Primula species

Concise total synthesis of (+/-)-aloperine and 6-epi-aloperine

Covalent Nucleoside Adducts of Aspidosperma Alkaloids

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

Enantiopure 2-piperidylacetaldehyde as a useful building block in the diversity-oriented synthesis of polycyclic piperidine derivatives

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

Farinose alpine Primula species: phytochemical and morphological investigations.

Functionalization at C-17 of an Eburnea-Aspidosperma Binary Alkaloid as a Model to Study Modified Vinblastine-type Antitumor Alkaloids

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

Histone demethylating agents as potential S-adenosyl-l-methionine-competitors

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling ⬇️

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

Natural Products and Cancer Stem Cells.

Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

New flavonol glycosides from Aconitum burnatii Gáyer and Aconitum variegatum L.

Novel chemical probes for the investigation of nonribosomal peptide assembly.

Preparation of Fluorescent Tubulin Binders

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Remote stereocenter discrimination in the enzymatic resolution of piperidine-2-ethanol. Short enantioselective synthesis of sedamine and allosedamine.

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

Self-assembly drug conjugates for anticancer treatment

Synthesis and biological evaluation of epothilone A dimeric compounds.

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

Synthesis and biological evaluation of novel tamoxifen analogues

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids

Synthesis and biological evaluation of pyrroloiminoquinone derivatives

Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies

Synthesis of Pironetin-Dumetorine Hybrids as Tubulin Binders

Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders

Synthetic studies on indole alxaloids. A stereocontrolled entry to the cuanzine structural unit

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

Tools for the rational design of bivalent microtubule-targeting drugs.

Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach

Total enantioselective synthesis of (-)-cytisine

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines