List of works - Michael B. Wheeler

3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis

scientific article published on 06 September 2018

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

scientific article

A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes

scientific article published on 23 June 2016

A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

scientific article

A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor

scientific article

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment

scientific article published in November 2002

Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion

scientific article

Alkali pH directly activates ATP-sensitive K+ channels and inhibits insulin secretion in beta-cells

scientific article published on 26 September 2006

Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study

scientific article published on 20 May 2020

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

scientific article published on 16 October 2003

Antidiabetic effects of duodenojejunal bypass in an experimental model of diabetes induced by a high-fat diet

scientific article published on 4 March 2011

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

scientific article published on 28 April 2010

Beta-cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression

scientific article published on May 1999

Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion

scientific article

Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo

scientific article published in March 2001

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets

scientific article published on 18 August 2009

Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

scientific article

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.

scientific article published on 12 May 2015

Characterization of glucagon-like peptide-1 receptor-binding determinants

scientific article (publication date: December 2000)

Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization

scientific article published on 01 August 1999

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

scientific article

Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor

scientific article published on 14 July 2015

Decreased CRH mRNA expression in the fetal guinea pig hypothalamus following maternal nutrient restriction

scientific article published in March 2001

Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo.

scientific article published on 26 September 2015

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells

scientific article published on 15 January 2008

Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis

scientific article published on 8 April 2004

Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance

scientific article published on 10 February 2010

Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.

scientific article published on 26 July 2012

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8 ⬇️

scientific article published on February 14, 2012

Elevated Medium Chain-Acylcarnitines are Associated with Gestational Diabetes, and Early Progression to Type-2 Diabetes, and Induce Pancreatic β-Cell Dysfunction.

scientific article published on 7 February 2018

Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice

scientific article published on September 2006

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice

scientific article published in July 1998

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

scientific article

Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo

scientific article published on June 2006

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo

scientific article published on 06 August 2007

Evolution of receptors for proglucagon-derived peptides: isolation of frog glucagon receptors

scientific article

Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids

scientific article

Expression of {beta}1 integrin receptors during rat pancreas development--sites and dynamics

scientific article published on 23 December 2004

FFAR out new targets for diabetes

scientific article published on 01 March 2015

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

scientific article published on 23 September 2004

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

scientific article published on 23 August 2007

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells

scientific article

GABA stimulates β-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel GABAA -R positive allosteric modulator

scientific article published on 18 June 2020

GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro

scientific article published on April 1997

Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration

scientific article published on 31 January 2006

Gastrin release in obese Zucker rats

scientific article

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

scientific article published on January 2004

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

scientific article published in May 1999

Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism

scientific article published on September 2002

Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin

scientific article published on March 2007

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

scientific article published on 01 March 2012

Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells

scientific article published on 14 July 2005

Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion

scientific article

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

scientific article

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

scientific article

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

scientific article published on 20 September 2002

Insulin mimetics in Urtica dioica: structural and computational analyses of Urtica dioica extracts

scientific article

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

scientific article published on 15 December 2005

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

scientific article

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

scientific article

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

scientific article published on 4 February 2008

Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes

scientific article published on 19 August 2015

Isolation and immortalization of MIP-GFP neurons from the hypothalamus

scientific article published on 10 March 2014

LKB1 couples glucose metabolism to insulin secretion in mice.

scientific article published on 16 April 2015

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes

scientific article published on 9 June 2005

Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells

scientific article published on 26 December 2007

Liver-specific expression of dominant-negative transcription factor 7-like 2 causes progressive impairment in glucose homeostasis

scientific article published on 09 January 2015

Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor

scientific article published on 01 June 1997

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

scientific article published in October 2009

MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice

scientific article published on 24 April 2012

Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.

scientific article

Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

scientific article published on 17 March 2003

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes

scientific article

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice

scientific article

Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.

scientific article published on 20 July 2006

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

scientific article published in July 1999

PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

scientific article

Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

scientific article

Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells

scientific article

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells

scientific article

Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells

scientific article published on 6 December 2012

Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development.

scientific article published on 16 March 2016

Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.

scientific article published on October 2011

Response to Comment on: Allister et al. UCP2 regulates the glucagon response to fasting and starvation. Diabetes 2013;62:1623-1633.

scientific article published on August 2013

Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop

scientific article published on 01 April 1997

Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor

scientific article published on 23 August 2012

Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39)

scientific article published on 01 January 1994

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.

scientific article published on 26 January 2011

Studies of melatonin effects on epithelia using the human embryonic kidney-293 (HEK-293) cell line

scientific article published on November 1997

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus

scientific article (publication date: November 2002)

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling

scientific article published on 15 February 2007

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

scientific article

The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity

scientific article published on 15 June 2015

The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties.

scientific article

The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel

scientific article published on 30 December 2005

The adult mouse and human pancreas contain rare multipotent stem cells that express insulin

scientific article

The characterization of mitochondrial permeability transition in clonal pancreatic beta-cells. Multiple modes and regulation

scientific article published on July 2004

The effect of total parenteral nutrition (TPN) on gastrin release in the rat.

scientific article

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

scientific article published on 11 November 2011

The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.

scientific article

The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity

scientific article

The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach

scientific article published on 30 April 2008

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing.

scientific article published on 20 June 2013

The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion

scientific article published on 21 May 2020

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion

scientific journal article

The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system

scientific journal article

Thermally induced gelable polymer networks for living cell encapsulation

scientific article published on January 2007

Transcription factor expression in the developing human fetal endocrine pancreas

scientific article published on 20 May 2008

UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival

scholarly article

UCP2 regulates the glucagon response to fasting and starvation

scientific article published on 22 February 2013

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin

scientific article published on 27 July 2009

Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets

scientific article published on 15 April 2011

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

scientific article published on June 2001

Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop Type 2 diabetes

scientific article published on 04 August 2020

Zip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells.

scientific article

α-Lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells

scientific article published on 13 May 2006

List of works by Michael B. Wheeler

3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes

A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment

Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion

Alkali pH directly activates ATP-sensitive K+ channels and inhibits insulin secretion in beta-cells

Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

Antidiabetic effects of duodenojejunal bypass in an experimental model of diabetes induced by a high-fat diet

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

Beta-cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression

Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion

Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets

Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.

Characterization of glucagon-like peptide-1 receptor-binding determinants

Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor

Decreased CRH mRNA expression in the fetal guinea pig hypothalamus following maternal nutrient restriction

Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo.

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells

Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis

Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance

Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8 ⬇️

Elevated Medium Chain-Acylcarnitines are Associated with Gestational Diabetes, and Early Progression to Type-2 Diabetes, and Induce Pancreatic β-Cell Dysfunction.

Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo

Evolution of receptors for proglucagon-derived peptides: isolation of frog glucagon receptors

Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids

Expression of {beta}1 integrin receptors during rat pancreas development--sites and dynamics

FFAR out new targets for diabetes

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells

GABA stimulates β-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel GABAA -R positive allosteric modulator

GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro

Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration

Gastrin release in obese Zucker rats

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism

Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells

Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

Insulin mimetics in Urtica dioica: structural and computational analyses of Urtica dioica extracts

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes

Isolation and immortalization of MIP-GFP neurons from the hypothalamus

LKB1 couples glucose metabolism to insulin secretion in mice.

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes

Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells

Liver-specific expression of dominant-negative transcription factor 7-like 2 causes progressive impairment in glucose homeostasis

Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice

Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.

Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice

Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells