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List of works by Nils Billestrup

Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

scientific article

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

scientific article

Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents.

scientific article published on 02 April 2015

CRFR1 activation protects against cytokine-induced β-cell death

scientific article published on 16 October 2014

CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

scientific journal article

Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells

scientific article

Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy

scientific article published on 23 September 2014

Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

scientific article published on 3 February 2015

Cytokines and beta-cell biology: from concept to clinical translation

scientific article

Dedifferentiation for replication of human beta-cells: a division between mice and men?

scientific article published in June 2008

Deficient SOCS3 and SHP-1 expression in psoriatic T cells

scientific article

Developmental expression of proprotein convertase 1/3 in the rat.

scientific article

Diabetes and suppressors of cytokine signaling proteins

scientific article published on February 2007

Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

scientific article

Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins

scientific article published on 29 October 2009

Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization.

scientific article published on July 1996

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

article

Effects of growth hormone on glucose and fat metabolism in human subjects.

scientific article published on March 2007

Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

scientific article published on 21 January 2011

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

scientific article published on 11 November 2005

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

scientific article published in March 2009

GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus

scientific article published on 06 June 2006

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

scientific article published in Journal of Biological Chemistry

Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.

scientific article

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

scientific article published on 10 March 2006

Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas.

scientific article published on September 1997

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

scientific article published on January 1998

Growth hormone receptor expression and function in pituitary adenomas

scientific article

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

scientific article

Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling

scientific article

Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor

scientific article published in September 1995

Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

scientific article

Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

scientific article published on 25 January 2011

ID’ing a Novel Inhibitor of β-Cell Function, Id1 ⬇️

scientific article published on October 1, 2011

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

scientific article

IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

scientific article published on 23 May 2006

Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene

scientific article published on June 1996

Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation

scientific article published on 01 July 1995

Impact of fasting on growth hormone signaling and action in muscle and fat.

scientific article published on 9 December 2008

Impact of fetal and neonatal environment on beta cell function and development of diabetes

scientific article published on 10 October 2014

Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

scientific article published on 16 October 2014

Inhibition of beta cell growth and function by bone morphogenetic proteins

scientific article

Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

scientific article published on 31 January 2007

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

scientific article

Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells

scientific article published on January 2001

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression

scientific article

JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

scientific journal article

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

article published in the Proceedings of the National Academy of Sciences of the United States of America

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

scientific article published on 28 September 2010

Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

scientific article

Molecular dissection of the growth hormone receptor. Identification of distinct cytoplasmic domains corresponding to different signaling pathways

scientific article published on 01 September 1995

Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes.

scientific article published on 6 July 2010

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

scientific article published on 25 August 2005

Nuclear translocation and retention of growth hormone

scientific article published in July 2003

Preparation of 125I-protein A usable for up to 10 months in immunoassays

scientific article published on 01 July 1984

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

scientific article published on 26 May 2009

Proliferation of sorted human and rat beta cells

scientific article published on 10 November 2007

Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.

scientific article

Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function

scientific article published on 01 September 1995

SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling.

scientific article published in March 2003

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

scientific article

STAT5 activity in pancreatic β-cells

scientific article published on 01 July 2008

Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

article

Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

scientific article published on 16 March 2006

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

scientific article

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

scientific article

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

scientific article published on 22 July 2008

Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells

scientific article

Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues

scientific article

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

scientific article published on 20 November 2015

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

scientific article published on 4 April 2015

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

scientific article

The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

scientific article published in September 2002

The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation

scientific article published on April 2003

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

scientific article published on May 1996

β-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice

scientific article published on 13 January 2011

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