List of works - Guozhi Tang

A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles

scientific article published on 18 November 2019

Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.

scientific article published on February 2008

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

scientific article

Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors

scientific article published on 7 June 2011

Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors

scientific article

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

scientific article published on 24 March 2017

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

scientific article published on 25 June 2016

Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors.

scientific article

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development

scientific article published on 24 June 2020

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.

scientific article published on 19 August 2010

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

scientific article published on 13 February 2017

Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform

scientific article published on 10 July 2016

Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.

scientific article

Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin

scientific article

Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response

scientific article

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

scientific article published on 23 March 2007

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

scientific article published on 7 June 2007

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

scientific article published on October 2006

Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes

scientific article published on 01 July 2002

List of works by Guozhi Tang

A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles

Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors

Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors.

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform

Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.

Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin

Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes