Search filters

List of works by Wynand P Roos

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine

scientific article published on 3 July 2006

Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related

scientific article published on November 2003

Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

scientific article

Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling

scientific article published on 17 January 2008

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

scientific article

Assessing the Effect of Class I Histone Deacetylase Activity on DNA Double-Strand Break Repair by Homologous Recombination

scientific article published in January 2017

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells.

scientific article

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs

scientific article published on 21 October 2008

Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling.

scientific article published on 28 January 2017

Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response.

scientific article

Contribution of ATM and ATR to the Resistance of Glioblastoma and Malignant Melanoma Cells to the Methylating Anticancer Drug Temozolomide ⬇️

scientific article published on August 19, 2013

Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts

scientific article published on 25 March 2014

DNA damage and the balance between survival and death in cancer biology

scientific article

DNA damage-induced cell death by apoptosis.

scientific article published on 8 August 2006

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis ⬇️

scientific article published on January 17, 2012

DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).

scientific article

Determination of the initial DNA damage and residual DNA damage remaining after 12 hours of repair in eleven cell lines at low doses of irradiation

scientific article

Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks.

scientific article published on December 2007

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance.

scientific article

In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi) ⬇️

scientific article published on 03 July 2020

Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

scientific article published on 14 April 2011

Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks

scientific article published in February 2006

Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair ⬇️

scientific article published on April 22, 2013

Mechanisms of human DNA repair: an update

scientific journal article

Micronucleus response of human glioblastoma and neuroblastoma cells toward low-LET photon and high-LET p(66)/Be neutron irradiation

scientific article published on June 2003

Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair

scientific article published on 27 April 2007

Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.

scientific article published on 20 August 2010

O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry ⬇️

scientific article published on July 1, 2011

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

scientific article published on 9 January 2006

Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles

scientific article published on 18 January 2010

Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

scientific article

Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs

scientific article

Response of pancreatic cancer cells treated with interferon-alpha or beta and co-exposed to ionising radiation.

scientific article published on September 2010

Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage

scientific article

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy

scientific article published on 06 February 2014

Temozolomide induces senescence and repression of DNA repair pathways in glioblastoma cells via activation of ATR-CHK1, p21, and NF-kB

scientific article published on 25 October 2018

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

scientific article published on 6 January 2009

The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death

scientific article published on 22 February 2019

The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

scientific article published on 12 May 2015

The influence of chromatin structure on initial DNA damage and radiosensitivity in CHO-K1 and xrs1 cells at low doses of irradiation 1-10 Gy.

scientific article published on 7 September 2002

The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

scientific article

The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

scientific article

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation

scientific article published on 15 October 2008

XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair

scientific article published on 21 March 2018

p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.

scientific article published on 10 February 2009

Paulina is supported by:

About Paulina

Help