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List of works by Sachio Morimoto

A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion

scientific journal article

A pH-sensitive interaction of troponin I with troponin C coupled with strongly binding cross-bridges in cardiac myofilament activation

scientific article published in April 2001

Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β

scientific article published on 04 October 2013

Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis.

scientific article

Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells

scientific article published on 17 February 2005

Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway

scientific article published on 16 September 2010

Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells

scientific article published on 7 December 2007

Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects

scientific article published on 01 January 2008

Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects

scientific article published on 01 October 2008

Biological actions of green tea catechins on cardiac troponin C.

scientific article

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

scientific article

Ca2+ binding to cardiac troponin C in the myofilament lattice and its relation to the myofibrillar ATPase activity

scientific article published in December 1994

Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy

scientific article published on 01 March 1999

Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy ⬇️

scientific article published on July 1, 1998

Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy

scientific article published on 16 August 2010

CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.

scientific article published on 31 January 2018

Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization

scientific article (publication date: December 2003)

Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation

scientific article published on 16 March 2017

Cardiomyopathies: classification, clinical characterization, and functional phenotypes

scientific article published on 4 December 2012

Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins

scientific article

Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca2+ transients

scientific article published on 20 November 2017

Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited dilated cardiomyopathy mouse model.

scientific article

Celecoxib induces apoptosis by inhibiting the expression of survivin in HeLa cells

scientific article published on 19 April 2007

Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells

scientific article published on 05 January 2007

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells.

scientific article

Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.

scientific article published in October 2004

Connexin45 contributes to global cardiovascular development by establishing myocardial impulse propagation.

scientific article published on 22 February 2016

DIF-1 inhibits the Wnt/β-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines

scientific article published on 8 October 2011

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

scientific article published on 23 March 2014

Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.

scientific article

Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity

scientific article published on 20 February 2010

Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells

scientific article published on 8 January 2003

Differentiation-inducing factor-1 alters canonical Wnt signaling and suppresses alkaline phosphatase expression in osteoblast-like cell lines

scientific article published on August 2006

Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma

scientific article

Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells

scientific article published on 14 October 2005

Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines.

scientific article published on 25 January 2013

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

scientific article published on 24 March 2015

Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.

scientific article

Effect of troponin I phosphorylation by protein kinase A on length-dependence of tension activation in skinned cardiac muscle fibers

scientific article published on 01 May 2000

Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice

scientific article

Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction

scientific article published on 14 December 2012

Expanded spectrum of gene causing both hypertrophic cardiomyopathy and dilated cardiomyopathy

scientific article published on 01 August 2009

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity

scientific article

Functional Consequences of the Mutations in Human Cardiac Troponin I Gene Found in Familial Hypertrophic Cardiomyopathy ⬇️

scientific article published on December 1, 2001

Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T

scientific article (publication date: 22 July 1999)

Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts

scientific article published in April 2004

Improvement of Left Ventricular Dysfunction and of Survival Prognosis of Dilated Cardiomyopathy by Administration of Calcium Sensitizer SCH00013 in a Mouse Model

scientific article published on 01 April 2010

In vivo effects of propyl gallate, a novel Ca(2+) sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation

scientific article published on 12 June 2014

Inherited cardiomyopathies caused by troponin mutations.

scientific article published on March 2013

Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation

scientific article published in June 2004

Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation

scientific article published on 07 June 2007

Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice

scientific article published on 12 December 2008

Molecular pathogenic mechanisms of cardiomyopathies caused by mutations in cardiac troponin T.

scientific article published on January 2007

Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy

scientific article

Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance

scientific article published on 16 February 2018

PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts

scientific article published in August 2004

Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament

scientific article published in March 2009

Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression.

scientific article

Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure

scientific article published on 19 August 2012

Role of protein kinase C in thin filament activation by rigor-like cross-bridges under ischemic conditions

scientific article published on 21 June 2009

Role of troponin I isoform switching in determining the pH sensitivity of Ca(2+) regulation in developing rabbit cardiac muscle

scientific article published in January 2000

SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure

scientific article published on 8 January 2005

Sarcomeric proteins and inherited cardiomyopathies.

scientific article published on 04 December 2007

Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure

scientific article

Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis

scientific article

Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy.

scientific article

Synthetic peptides of actin-tropomyosin binding region of troponin I and heat shock protein 20 modulate the relaxation process of skinned preparations of taenia caeci from guinea pig

scientific article published on 01 December 2005

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

scientific article published on 03 May 2011

Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes

scientific article

Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo

scientific article published on 16 July 2008

The effect of Mg2+ on the Ca2+ binding to troponin C in rabbit fast skeletal myofibrils ⬇️

scientific article published on 01 March 1991

Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation.

scientific article published on 28 May 2009

Troponin I inhibitory peptide suppresses the force generation in smooth muscle by directly interfering with cross-bridge formation

scientific article

Troponin isoform dependent pH dependence of the Ca(2+)-activated myofibrillar ATPase activity of avian slow and fast skeletal muscles

scientific article published on 01 February 1995

Troponin: regulatory function and disorders.

scientific article published on 26 December 2007

Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy

scientific article published on 7 May 2010

Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model

scientific article

Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O.

scientific article published on 2 June 2015

β(1)-Adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects

scientific article published on 16 March 2011

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