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List of works by Karen Piper Hanley

Development of the human pancreas from foregut to endocrine commitment.

scientific article published on 29 April 2013

Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

scientific article published on 06 August 2020

Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis

scientific article

Embryonic stem cells to beta-cells by understanding pancreas development

scientific article published on 27 March 2008

Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.

scientific article

Evaluating Human Embryonic Germ Cells: Concord and Conflict as Pluripotent Stem Cells

scientific article

Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening

scientific article published on 04 March 2010

Human embryonic germ cells for future neuronal replacement therapy

scientific article

Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc

scientific article published in Scientific Reports

In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development

scientific article

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

scientific article

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

scientific journal article

Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome

scientific article

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans

scientific article published on September 2012

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

scientific article published on 18 August 2016

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. ⬇️

scientific article

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

scientific article published on July 2013

Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats

scientific article published on 19 July 2019

SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis.

scientific article published on 6 November 2017

The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development.

scientific article

The window period of NEUROGENIN3 during human gestation

scientific article

Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1

scientific article

Understanding the role of SOX9 in acquired diseases: lessons from development

scientific article published on 13 January 2011

Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?

scientific article published on 16 March 2008

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