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List of works by George Simos

2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

scientific article

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression

scientific article published on 10 April 2014

A nuclear envelope-associated kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins

scientific article published on 01 April 1996

An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis

scientific article

Arc1p organizes the yeast aminoacyl-tRNA synthetase complex and stabilizes its interaction with the cognate tRNAs.

scientific article

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK.

scientific article

Bacterially produced human HIF-1alpha is competent for heterodimerization and specific DNA-binding.

scientific article

Barley beta-glucosidase: expression during seed germination and maturation and partial amino acid sequences

scientific article published on 01 January 1994

Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

scientific article published on 10 September 2011

Building arks for tRNA: structure and function of the Arc1p family of non-catalytic tRNA-binding proteins

scientific article published on 20 August 2010

CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation

scientific article

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

scientific article published on 10 August 2010

Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop.

scientific article published in January 1998

Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism

scientific article published on 01 August 2006

Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism

scientific article published on 15 July 2004

Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells

scientific article published on 16 August 2013

Combinatorial regulation by ERK1/2 and CK1δ protein kinases leads to HIF-1α association with microtubules and facilitates its symmetrical distribution during mitosis

scientific article published in 2024

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

scientific article published on 15 February 2018

ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling

scientific article published on 08 April 2019

Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1alpha

scientific article

Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect

scientific article

Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1{alpha} and airway responsiveness to ACh

scientific article published on 27 July 2007

Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia

scientific article published on 15 June 2018

Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity

scientific article published on 7 November 2007

HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

scientific article published on 10 December 2018

HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia

scientific article

High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6.

scientific article published on 19 March 2013

Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway

scientific article published on 24 December 2019

Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression

scientific article

Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma

scientific article

Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism

Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen

scientific article published on 29 March 2019

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha.

scientific article published on 5 September 2006

Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex

scientific article published on 21 June 2008

Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides

scientific article published on 26 June 2009

Intron-dependent enzymatic formation of modified nucleosides in eukaryotic tRNAs: a review

scientific article published on May 1997

Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer

scientific article published on 01 May 2010

Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency

scientific article

Lamins and lamin-associated proteins.

scientific article published on June 1994

Low Serum Hepcidin in Patients with Autoimmune Liver Diseases

scientific article published on 13 August 2015

Low oxygen tension enhances hepatitis C virus replication.

scientific article

MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity

scientific article published on 01 January 2007

MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization

scientific article published on 28 February 2013

Mitotic phosphorylation of the lamin B receptor by a serine/arginine kinase and p34(cdc2)

scientific article published on 01 March 1997

Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly

scientific article published on 11 October 2007

Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia

scientific article published in December 2016

Nuclear export of tRNA.

scientific article

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.

scientific article

Nucleocytoplasmic transport: factors and mechanisms

scientific article published on August 1995

Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera

scientific article published on 8 May 2013

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study

scientific article

Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity

scientific article published on 15 February 2019

Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast.

scientific article published on 24 September 2001

Reconstitution of human hypoxia inducible factor HIF-1 in yeast: a simple in vivo system to identify and characterize HIF-1alpha effectors

scientific article published on 16 June 2006

Role of Arc1p in the modulation of yeast glutamyl-tRNA synthetase activity

scientific article published in February 2005

Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes

scientific article published on 12 August 2006

TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells

scientific article published in August 2013

The Role of Sumoylation in the Response to Hypoxia: An Overview

scientific article published on 26 October 2020

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions

scientific article published on 15 June 2010

The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron

scientific article published on 01 March 2007

The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p

scientific article

The lamin B receptor-associated protein p34 shares sequence homology and antigenic determinants with the splicing factor 2-associated protein p32

scientific article published on 01 June 1994

The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism

scientific article

The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity ⬇️

scientific article published on July 1, 1998

Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.

scientific article published on 27 September 2009

Upregulation of VEGF expression is associated with accumulation of HIF-1α in the skin of naïve scleroderma patients.

scientific article

Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA

scientific article

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

scientific article published on 5 October 2010

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