Search filters

List of works by Annemarie Honegger

A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein

scientific article published on 24 March 2015

A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex

scientific article

A natural antibody missing a cysteine in VH: consequences for thermodynamic stability and folding.

scientific article

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction

scientific article published on March 1988

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 ⬇️

scientific article published on October 1, 1991

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.

scientific article published on 31 January 2018

Affinity and folding properties both influence the selection of antibodies with the selectively infective phage (SIP) methodology.

scientific article published on October 1997

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase

scientific article published on August 1993

All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor

scientific journal article

Antibody scFv fragments without disulfide bonds made by molecular evolution

Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites

scientific article published on October 1988

Biophysical properties of human antibody variable domains

scientific article

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

scientific article published on 4 November 2016

Chemical modification of peptides by hydrazine

scientific article published on October 1981

Comparison of buffers and detection systems for high-pressure liquid chromatography of peptide mixtures

scientific article published on October 1981

Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition

scientific article

Correlation between in Vitro Stability and in Vivo Performance of Anti-GCN4 Intrabodies as Cytoplasmic Inhibitors

scientific article published in Journal of Biological Chemistry

Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations

scientific article

Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen

scientific article

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors

scientific article published on October 1989

DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography

scientific article

DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency

scientific article

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

scientific article

Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework

scientific article

Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment

scientific article published in April 1997

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

scientific article

Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells

scholarly article by Todd A Braciak et al published 2018 in OncoImmunology

Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems

scientific article published on 17 December 2014

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

scientific article published on 18 June 2021

Engineering antibodies for stability and efficient folding.

scientific article published on January 2008

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

scientific article published on August 1990

Expression of a human insulin-like growth factor II cDNA in NIH-3T3 cells

scientific article published on June 1990

Folding Nuclei of the scFv Fragment of an Antibody†

scientific article published in 1996

Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity

scientific article published on April 1990

High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment

scientific article published on 01 November 1999

Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide

scientific article

Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities

scientific article published in Journal of Biological Chemistry

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk

scientific article

Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites

scientific article published on October 1988

Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants

scientific article published on April 1989

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

scientific article published on October 1987

Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor ⬇️

scientific article published on May 15, 1992

Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv.

scientific article

Reproducing the natural evolution of protein structural features with the selectively infective phage (SIP) technology. The kink in the first strand of antibody kappa domains.

scientific article

Rigidly connected multispecific artificial binders with adjustable geometries.

scientific article

Selection for improved protein stability by phage display.

scientific article

Selection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries

scientific article

Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells

scientific article published on May 1990

Signal Transduction by Epidermal Growth Factor Receptor

scientific article published on 01 January 1988

Specific detection of his-tagged proteins with recombinant anti-His tag scFv-phosphatase or scFv-phage fusions

scientific article published on 01 January 1997

Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering

scientific article published in October 2004

Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework

scientific article published in February 2009

Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2

scientific article

Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach

scientific article

T-cell receptor gene transfer exclusively to human CD8(+) cells enhances tumor cell killing

scientific article

The behaviour of peptides on reverse-phase supports during high-pressure liquid chromatography

scientific article published on October 1981

The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

scientific article

The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains

scientific article

The influence of the buried glutamine or glutamate residue in position 6 on the structure of immunoglobulin variable domains

scientific article published in June 2001

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

scientific article published on 10 January 2009

The nature of antibody heavy chain residue H6 strongly influences the stability of a VH domain lacking the disulfide bridge

Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library.

scientific article

Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool

article

Paulina is supported by:

About Paulina

Help