List of works by Julian Hiscox

A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus.

scientific article published on 27 February 2017

A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging.

scientific article

A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture

scientific article published on 14 May 2012

ACE2: from vasopeptidase to SARS virus receptor ⬇️

scientific article

An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC-based quantitative proteomics

scientific article published in April 2012

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

scientific article published in 2022

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

scientific article published on 01 May 2022

Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge

scientific article

Antiviral Screening of Multiple Compounds against Ebola Virus

scientific article published on 27 October 2016

Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples

scientific article published on 01 December 2018

Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain

scientific article published on 28 January 2012

Cell cycle perturbations induced by infection with the coronavirus infectious bronchitis virus and their effect on virus replication

scientific article published in April 2006

Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus

scientific article published in July 2006

Characterisation of cyclin D1 down-regulation in coronavirus infected cells.

scientific article published on 28 February 2007

Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region

scientific article published on 2 October 2006

Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus.

scientific article published on 18 April 2018

Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus

scientific article published on 18 August 2013

Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins

scientific article published on 28 December 2015

Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells

scientific article published on 27 July 2011

Characterization of the nuclear export signal in the coronavirus infectious bronchitis virus nucleocapsid protein

scientific article published on 3 January 2007

Cross-species infection of mice by rabbit hepatitis E virus

scientific article published on 18 September 2018

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

scientific article published on 28 January 2014

Delineation and modelling of a nucleolar retention signal in the coronavirus nucleocapsid protein.

scientific article published on 25 May 2006

Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for

scientific article published on 17 June 2016

Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B.

scientific article published on 28 December 2011

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

scientific article published on 20 May 2010

Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets ⬇️

scientific article published on 27 October 2016

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function ⬇️

scientific article published on 23 October 2014

Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus

scientific article published on October 2010

Evaluation of a nucleoprotein-based enzyme-linked immunosorbent assay for the detection of antibodies against infectious bronchitis virus

scientific article published in October 2003

Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4

scientific article published on 04 January 2019

Expression and structural analysis of infectious bronchitis virus nucleoprotein

scientific article published in January 2006

Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase

scientific article published on 8 July 2014

GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity

scientific article

Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells

scientific article

Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle ⬇️

scientific article (publication date: 15 October 2016)

Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro

scientific article

Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication.

scientific article

Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β.

scientific article published on 7 August 2015

Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease

scientific article published on 28 November 2017

Infectious bronchitis coronavirus induces cell-cycle perturbations

scientific article published on January 2006

Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection

scientific article (publication date: 2016)

Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell

scientific article published on May 2002

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis

scientific article published on 29 October 2014

Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses

scientific article

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach ⬇️

scientific article published on 9 December 2015

Lithium chloride inhibits the coronavirus infectious bronchitis virus in cell culture

scientific article published on April 2007

MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection

scientific article published on 26 April 2016

Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance

scientific article published on January 2005

Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak

scientific article published on 01 January 2019

MicroRNA miR-24-3p promotes porcine reproductive and respiratory syndrome virus replication through suppression of heme oxygenase-1 expression

scientific article published on 4 February 2015

Neuropilin-1 is a host factor for SARS-CoV-2 infection

scientific article published on 20 October 2020

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization ⬇️

scientific article

Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin

scientific article published on 10 June 2011

Nucleolar proteomics and viral infection

scientific article

Nucleolar targeting: the hub of the matter

scientific article published on 20 February 2009

Nucleolin is regulated both at the level of transcription and translation.

scientific article published in July 2005

PK-15 cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus

scientific article published on 5 July 2013

Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 To Regulate Viral RNA Synthesis

scientific article published on 23 March 2016

Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

scientific article published on 06 November 2018

Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system

scientific article

Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology

scientific article published on 23 December 2014

Quantification of Ebola virus replication kinetics in vitro

scientific article published on 02 November 2020

Quantification of individual subgenomic mRNA species during replication of the coronavirus transmissible gastroenteritis virus

scientific article published in May 1995

Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus

scientific article published on 20 July 2010

Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS.

scientific article published on December 2010

Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells

scientific article published on October 2010

Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals changes in the cytoplasmic, nuclear, and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virus

scientific article

RNA viruses: hijacking the dynamic nucleolus

scientific article published on February 2007

Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission

scientific article published on 15 January 2017

Real-time, portable genome sequencing for Ebola surveillance

scientific article

Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5

scientific article published on 04 June 2018

Recombinant viral proteins for use in diagnostic ELISAs to detect virus infection

scientific article published on 6 March 2007

Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology

scientific article published on 30 December 2014

Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein

scientific article

Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein

scientific article published in October 2012

Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein.

scientific article

T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans

scientific article published on 01 November 2018

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa

scientific article published on 17 June 2015

The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release ⬇️

scientific article

The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology

scientific article published on May 2013

The coronavirus infectious bronchitis virus nucleoprotein localizes to the nucleolus.

scientific article published on January 2001

The crystal structure of the Hazara virus nucleocapsid protein ⬇️

scientific article

The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication

scientific article

The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology

scientific article (publication date: August 2012)

Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein.

scientific article published in January 2006

Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19

scientific article published on 01 February 2022

Trafficking motifs in the SARS-coronavirus nucleocapsid protein.

scientific article published on 14 May 2007

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus

scientific article published on 19 January 2017

Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes

scientific article published on 19 January 2012

Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

scientific article published on 07 September 2020

Viperin Poisons Viral Replication

scientific article published on 01 August 2018

Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus

scientific article published on 4 September 2008

Virus genomes reveal factors that spread and sustained the Ebola epidemic

scientific article (publication date: 12 April 2017)

Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity.

scientific article published on 28 March 2018

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