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List of works by Paul R. Clarke

A mitotic role for BRCA1/BARD1 in tumor suppression?

scientific article published in November 2006

Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.

scientific article published in January 1991

Anchoring RCC1 by the tail

scientific article

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.

scientific article published on 29 September 2009

Apoptosis: does stress kill?

scientific article published on December 1996

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

scientific article published on 09 July 2018

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

scientific article published on 01 March 1999

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

scientific article published on 01 August 1996

Bcl-2 regulates amplification of caspase activation by cytochrome c.

scientific article published in February 1999

Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase

scientific article published in August 1990

Cell biology. A gradient signal orchestrates the mitotic spindle

scientific article published in August 2005

Cell biology: Ran, mitosis and the cancer connection

scientific article (publication date: 20 June 2006)

Cell-cycle control in the face of damage--a matter of life or death.

scientific article published on 23 January 2009

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.

scientific article published in March 2015

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

scientific article published on 01 May 2000

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.

scientific article

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

scientific article published on 5 October 2010

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway

scientific article

Cleavage of rabaptin-5 blocks endosome fusion during apoptosis.

scientific article published on October 1997

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

scientific article published on 01 November 2002

Control of apoptosis and autophagy by cellular signalling pathways

scientific article published on 29 September 2009

Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis

scientific article

Cyclin-dependent kinases. CAK-handed kinase activation

scientific article

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

scientific article

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

scientific article published on April 1993

Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding

scientific article published in September 2002

Destruction's our delight: controlling apoptosis during mitotic arrest.

scientific article

Dynamic localisation of Ran GTPase during the cell cycle

scientific article

Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase

scientific article published on 01 November 1992

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

scientific article published on July 2003

Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.

scientific article published on 7 March 2001

Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

scientific article published on 9 February 2010

Mitosis: ran scales the alps of spindle formation

scientific article published on 01 August 2007

Nuclear pores: sowing the seeds of assembly on the chromatin landscape.

scientific article published on December 2003

Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

scientific article published on December 1993

Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly

scientific article published on 31 May 2013

Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

scientific article

Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death

scientific article published on 7 December 2016

Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

scientific article published on April 2007

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

scientific article published on 23 September 2019

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

scientific article

Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival

scientific article published on 27 May 2016

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c.

scientific article published on 9 February 2005

RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation

scientific article published on 12 September 2007

Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

scientific article

Ran alters nuclear pore complex conformation.

scientific article published in July 2000

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

scientific article

Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation

scientific article

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver

scientific article

Regulation of apoptosis by BH3 domains in a cell-free system

scientific article published on 01 December 1997

Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress

scientific article

Role of importin-beta in the control of nuclear envelope assembly by Ran.

scientific article published in March 2002

Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

scientific article

Signal transduction. Switching off MAP kinases

scientific article published on July 1994

Signaling to nuclear transport

scientific article published on 01 March 2008

Substrate specificity determinants of the checkpoint protein kinase Chk1

scientific article published on 01 January 2000

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

scientific article published on August 2002

The Crm de la crème of mitosis.

scientific article published in June 2005

The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125.

scientific article

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

scientific article

Timed degradation of Mcl-1 controls mitotic cell death

scientific article published on 11 October 2018

To the centre of the volcano. Workshop on the mechanisms of nucleocytoplasmic transport

scientific article published on 11 April 2008

USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability.

scientific article published in April 2018

hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks.

scientific article published on 11 February 2009

p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

scientific article published on 5 July 2009

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