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List of works by Aldo M Roccaro

A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation

scientific article

Advances in the treatment of monoclonal gammopaties: The emerging role of targeted therapy in plasma cell dyscrasias.

scientific article published in September 2008

Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas

scientific article published on 01 March 2002

Angiogenesis, angiogenic factor expression and hematological malignancies.

scientific article

Antiangiogenesis for rheumatoid arthritis.

scientific article

Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs

scientific article

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

scientific article published on April 2013

BM mesenchymal stromal cell–derived exosomes facilitatemultiple myeloma progression

scientific article

Balancing risk versus benefit in the treatment of Waldenström's Macroglobulinemia patients with nucleoside analogue-based therapy

scientific article published on 01 March 2009

Bone Marrow Stroma and Vascular Contributions to Myeloma Bone Homing.

scientific article published on 9 September 2017

Bone marrow angiogenesis and plasma cell angiogenic and invasive potential in patients with active multiple myeloma.

scientific article

Bone marrow angiogenesis in patients with active multiple myeloma.

scientific article

Bone marrow microenvironment in multiple myeloma progression.

scientific article published on 03 October 2012

Bortezomib and Waldenstrom's macroglobulinemia

scientific article published on 01 April 2009

Bortezomib as an antitumor agent.

scientific article published on December 2006

Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells

scientific article published in January 2006

C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma

scientific article published on 07 April 2014

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation

scientific article published on 16 July 2015

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

scientific article

CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma

scientific article

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model.

scientific article published on 7 January 2016

Candidate genes of Waldenström's macroglobulinemia: current evidence and research.

scientific article published on 17 July 2013

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

scientific article

Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in Waldenstrom's Macroglobulinemia.

scientific article published on 25 February 2011

Case-control study of multidrug resistance phenotype and response to induction treatment including or not fludarabine in newly diagnosed acute myeloid leukaemia patients

scientific article published on 01 January 2007

Cell Trafficking in Multiple Myeloma

scientific article published on February 2012

Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma

scientific article published on 01 April 2019

Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia

scientific article

Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenströms Macroglobulinemia

scientific article

Clinical relevance of soluble HLA class I molecules in Waldenstrom Macroglobulinemia

scientific article published on 10 March 2008

Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development of the vascular system in the chick embryo bursa of Fabricius

scientific article published on 01 April 2001

Defining the role of TORC1/2 in multiple myeloma ⬇️

scientific article published on December 22, 2011

Development of vasculature targeting strategies for the treatment of chronic inflammatory diseases.

scientific article

Distinct roles of class I PI3K isoforms in multiple myeloma cell survival and dissemination.

scientific article published on 25 April 2014

Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.

scientific article

Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia.

scientific article

Engineered nanomedicine for myeloma and bone microenvironment targeting.

scientific article

Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's macroglobulinemia

scientific article published on 18 October 2011

Epigenetic Aberrations in Multiple Myeloma

scientific article published on 15 October 2020

Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology

scientific article

Epigenetics in Waldenström's macroglobulinemia

scientific article published on 01 October 2010

Erythropoietin as an angiogenic factor.

scientific article published on October 2003

Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia.

scientific article published on 22 February 2016

Expression of regulatory genes for lymphoplasmacytic cell differentiation in Waldenstrom Macroglobulinemia

scientific article published on 06 February 2009

Extramedullary Waldenström macroglobulinemia

scientific article published on 19 November 2014

FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress

scientific article published on 24 February 2020

FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation ⬇️

scientific article (publication date: July 2011)

FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance

scientific article published in August 2005

Global epigenetic regulation of microRNAs in multiple myeloma

scientific article

Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

scientific article

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features ⬇️

scientific article published on March 6, 2012

Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation

scientific article published in April 2015

Incidence of bacterial and fungal infections in newly diagnosed acute myeloid leukaemia patients younger than 65 yr treated with induction regimens including fludarabine: retrospective analysis of 224 cases

scientific article published on 19 August 2008

Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenström macroglobulinemia treated with nucleoside analogs

scientific article published on 8 December 2008

Increased matrix-metalloproteinase-2 and matrix-metalloproteinase-9 expression in the brain of dystrophic mdx mouse.

scientific article published on 2 May 2006

Individualizing treatment for Waldenstrom's macroglobulinemia

scientific article published on 01 October 2009

Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

scientific article published on 20 June 2018

Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model.

scientific article

Key role of microRNAs in Waldenström's macroglobulinemia pathogenesis

scientific article published on 01 February 2011

Kinetics of Th1/Th2 cytokines and lymphocyte subsets to predict chronic GVHD after allo-SCT: results of a prospective study.

scientific article published on 27 April 2009

LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas

scientific article published on 13 July 2012

Mast cell contribution to angiogenesis related to tumour progression.

scientific article

Mechanisms of activity of the TORC1 inhibitor everolimus in Waldenstrom macroglobulinemia

scientific article published on 9 October 2012

Metabolic signature identifies novel targets for drug resistance in multiple myeloma

scientific article published on 13 March 2015

Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice.

scientific article

New Therapeutic Approaches for Waldenstrom Macroglobulinemia

scientific article

New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia.

scientific article published on July 2011

Novel agents in Waldenström macroglobulinemia.

scientific article

Novel agents in the treatment of Waldenström's macroglobulinemia.

scientific article published on August 2007

Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway

scientific article published on September 2005

Novel targeting of phospho-cMET overcomes drug resistance and induces antitumor activity in multiple myeloma.

scientific article published on 26 June 2013

Novel therapeutic avenues in myeloma: changing the treatment paradigm.

scientific article published on June 2007

Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma

scientific article

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment ⬇️

scientific article published on November 16, 2011

Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia

scientific article published on 03 July 2015

Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia

scientific article published in November 2002

Progression signature underlies clonal evolution and dissemination of multiple myeloma

scientific article published on 04 November 2020

Pyk2 promotes tumor progression in multiple myeloma

scientific article

ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Regulation of microRNAs in cancer metastasis.

scientific article published on 22 February 2014

Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia

scientific article

RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.

scientific article

Role of endothelial progenitor cells in cancer progression

scientific article published on 04 April 2014

Role of microRNAs from monoclonal gammopathy of undetermined significance to multiple myeloma

scientific article published in January 2011

Role of proteasome inhibition in Waldenström's macroglobulinemia.

scientific article published on March 2009

SDF-1 inhibition targets the bone marrow niche for cancer therapy

scientific article published on 25 September 2014

SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma

scientific article

Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia

scientific article published on 28 January 2010

Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia

scientific article published on 01 June 2008

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

scientific article published on February 2008

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

scientific article

Targeting NF-kappaB in Waldenstrom macroglobulinemia

scientific article

Targeting SDF-1 in multiple myeloma tumor microenvironment

scientific article

Targeting survival and cell trafficking in multiple myeloma and Waldenstrom macroglobulinemia using pan-class I PI3K inhibitor, buparlisib

scientific article

Targeting the bone marrow in Waldenstrom macroglobulinemia.

scientific article published on 30 April 2011

Targeting the bone marrow microenvironment in multiple myeloma.

scientific article

Targeting vasculogenesis to prevent progression in multiple myeloma

scientific article published on 3 February 2016

The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia

scientific article (publication date: 15 December 2007)

The Bone Marrow Niche in Waldenström's Macroglobulinemia ⬇️

scientific article published on February 1, 2011

The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia

scientific article published on 3 June 2008

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

scientific article published on April 2017

The bone marrow microenvironment in waldenstrom macroglobulinemia.

scientific article published on August 2011

The cancer glycome: carbohydrates as mediators of metastasis

scientific article

The role of miRNAs in plasma cell dyscrasias

scientific article published on 01 January 2014

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

scientific article

Tryptase-positive mast cells correlate positively with bone marrow angiogenesis in B-cell chronic lymphocytic leukemia

scientific article published in July 2003

Update on therapeutic options in Waldenström macroglobulinemia

scientific article

Vascular endothelial growth factor and its receptors in multiple myeloma.

scientific article

Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study

scientific article

microRNA aberrations and their role in supporting hematologic malignancies

scientific article published on 01 January 2014

microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia

scientific article

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