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List of works by Antonio Sacco

A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation

scientific article

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

scientific article published on April 2013

BM mesenchymal stromal cell–derived exosomes facilitatemultiple myeloma progression

scientific article

Bone Marrow Stroma and Vascular Contributions to Myeloma Bone Homing.

scientific article published on 9 September 2017

Bone marrow microenvironment in multiple myeloma progression.

scientific article published on 03 October 2012

C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma

scientific article published on 07 April 2014

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation

scientific article published on 16 July 2015

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

scientific article

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model.

scientific article published on 7 January 2016

Candidate genes of Waldenström's macroglobulinemia: current evidence and research.

scientific article published on 17 July 2013

Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in Waldenstrom's Macroglobulinemia.

scientific article published on 25 February 2011

Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma

scientific article published on 01 April 2019

Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia

scientific article

Defining the role of TORC1/2 in multiple myeloma ⬇️

scientific article published on December 22, 2011

Distinct roles of class I PI3K isoforms in multiple myeloma cell survival and dissemination.

scientific article published on 25 April 2014

Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.

scientific article

Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia.

scientific article

Engineered nanomedicine for myeloma and bone microenvironment targeting.

scientific article

Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's macroglobulinemia

scientific article published on 18 October 2011

Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology

scientific article

Epigenetics in Waldenström's macroglobulinemia

scientific article published on 01 October 2010

Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia.

scientific article published on 22 February 2016

FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation ⬇️

scientific article (publication date: July 2011)

Global epigenetic regulation of microRNAs in multiple myeloma

scientific article

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features ⬇️

scientific article published on March 6, 2012

Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia

scientific article (publication date: 15 April 2009)

Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenström macroglobulinemia treated with nucleoside analogs

scientific article published on 8 December 2008

Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model.

scientific article

Key role of microRNAs in Waldenström's macroglobulinemia pathogenesis

scientific article published on 01 February 2011

LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas

scientific article published on 13 July 2012

Mechanisms of activity of the TORC1 inhibitor everolimus in Waldenstrom macroglobulinemia

scientific article published on 9 October 2012

Metabolic signature identifies novel targets for drug resistance in multiple myeloma

scientific article published on 13 March 2015

Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice.

scientific article

Novel agents in the treatment of Waldenström's macroglobulinemia.

scientific article published on August 2007

Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma

scientific article

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment ⬇️

scientific article published on November 16, 2011

Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia

Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia

scientific article published on 03 July 2015

Progression signature underlies clonal evolution and dissemination of multiple myeloma

scientific article published on 04 November 2020

Pyk2 promotes tumor progression in multiple myeloma

scientific article

ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia

scientific article

RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.

scientific article

Role of proteasome inhibition in Waldenström's macroglobulinemia.

scientific article published on March 2009

SDF-1 inhibition targets the bone marrow niche for cancer therapy

scientific article published on 25 September 2014

Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia

scientific article published on 28 January 2010

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

scientific article published on 4 November 2021

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

scientific article

Targeting NF-kappaB in Waldenstrom macroglobulinemia

scientific article

Targeting survival and cell trafficking in multiple myeloma and Waldenstrom macroglobulinemia using pan-class I PI3K inhibitor, buparlisib

scientific article

Targeting the bone marrow in Waldenstrom macroglobulinemia.

scientific article published on 30 April 2011

Targeting vasculogenesis to prevent progression in multiple myeloma

scientific article published on 3 February 2016

The Bone Marrow Niche in Waldenström's Macroglobulinemia ⬇️

scientific article published on February 1, 2011

The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia

scientific article published on 3 June 2008

The bone marrow microenvironment in waldenstrom macroglobulinemia.

scientific article published on August 2011

The role of miRNAs in plasma cell dyscrasias

scientific article published on 01 January 2014

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

scientific article

microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia

scientific article

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