List of works - Peter McIntyre

7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hy

scientific article published on 7 May 2012

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

scientific article published on 17 November 2017

A TRP channel that senses cold stimuli and menthol

scientific journal article

A carbamylphosphate synthetase deficiency with no detectable immunoreactive enzyme and no translatable mRNA

scientific article published on 01 January 1984

A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.

scientific article published on 5 April 2016

A heat-sensitive TRP channel expressed in keratinocytes

scientific journal article

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

scientific journal article

Altered substrate selectivity of PKC-eta pseudosubstrate site mutants

scientific article published on 01 August 1993

Analysing calcium signalling of cells under high shear flows using discontinuous dielectrophoresis.

scientific article

Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor

scientific article

B1 and B2 bradykinin receptors encoded by distinct mRNAs.

scientific article published on April 1994

Biochemical properties of rat protein kinase C-eta expressed in COS cells

scientific article published on November 9, 1992

CHAPTER 4. Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification

Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia

scientific article published on 01 July 1998

Characterisation of a mouse cerebral microvascular endothelial cell line (bEnd.3) after oxygen glucose deprivation and reoxygenation.

scientific article published on 29 April 2016

Cloning and functional characterization of the guinea pig vanilloid receptor 1.

scientific article

Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist.

scientific article

Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints

scientific article published on 01 July 1997

Concurrent shear stress and chemical stimulation of mechano-sensitive cells by discontinuous dielectrophoresis

scientific article

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function

scientific journal article

Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

scientific article published in June 2017

Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse

scientific article published on 27 February 2014

Examination of the role of transient receptor potential vanilloid type 4 in endothelial responses to shear forces.

scientific article

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular choroid plexus of the rat.

scientific article

Expression of functional bradykinin receptors in Xenopus oocytes

scientific article published on January 1992

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

scientific article

Glial cell line derived neurotrophic factor (GDNF) regulates VR1 and substance P in cultured sensory neurons

scientific article published on July 1999

Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain

scientific article published in January 2006

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.

scientific article published on 11 February 2004

Immunology on chip: promises and opportunities.

scientific article

Induction of gene amplification by 5-aza-2'-deoxycytidine

scientific article published on May 1992

Influence of epitopes CD44v3 and CD44v6 in the invasive behavior of fibroblast-like synoviocytes derived from rheumatoid arthritic joints

scientific article published on 01 August 2002

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1.

scientific article published on 28 January 2014

Modulation of TRPV4 by diverse mechanisms

scientific article

Modulation of the TRPV4 ion channel as a therapeutic target for disease

scientific article published on 12 February 2017

Molecular Sensors of Blood Flow in Endothelial Cells

scientific article published on 12 August 2017

Molecular studies on kinin receptors

scientific article

Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

scientific article published on 2 October 2011

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

scientific article

Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists

scientific article

Patents associated with high-cost drugs in Australia

scientific article

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons.

scientific article

Potent and orally bioavailable non-peptide antagonists at the human bradykinin B(1) receptor based on a 2-alkylamino-5-sulfamoylbenzamide core

scientific article published in September 2004

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

scientific article published on 3 January 2013

Putative glycophorin-binding protein is secreted from schizonts of Plasmodium falciparum.

scientific article

Regulation of bradykinin receptor gene expression in human lung fibroblasts

scientific article

Selection of a cDNA clone which contains the complete coding sequence for the mature form of ornithine transcarbamylase from rat liver: expression of the cloned protein in Escherichia coli. Molecular cloning of rat ornithine transcarbamylase ⬇️

scientific article published on August 15, 1984

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

scientific article published on 8 June 2014

Shear Stress Regulates TRPV4 Channel Clustering and Translocation from Adherens Junctions to the Basal Membrane.

scientific article published on 21 November 2017

Shear stress mediates exocytosis of functional TRPV4 channels in endothelial cells

scientific article published on 20 August 2015

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation

scientific article published on 19 May 2018

Sites of action of ghrelin receptor ligands in cardiovascular control

scientific article published on 10 August 2012

Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability

scientific article published on April 1999

The CD44v7/8 epitope as a target to restrain proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.

scientific article published on December 2000

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

scientific article published on January 2015

The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.

scientific article

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

scientific article

The cDNA cloning and immunological characterization of hamster p53.

scientific article

The primary structure of the imported mitochondrial protein, ornithine transcarbamylase from rat liver: mRNA levels during ontogeny

scientific article published in April 1985

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

scientific article

List of works by Peter McIntyre

7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hy

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

A TRP channel that senses cold stimuli and menthol

A carbamylphosphate synthetase deficiency with no detectable immunoreactive enzyme and no translatable mRNA

A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.

A heat-sensitive TRP channel expressed in keratinocytes

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

Altered substrate selectivity of PKC-eta pseudosubstrate site mutants

Analysing calcium signalling of cells under high shear flows using discontinuous dielectrophoresis.

Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor

B1 and B2 bradykinin receptors encoded by distinct mRNAs.

Biochemical properties of rat protein kinase C-eta expressed in COS cells

CHAPTER 4. Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification

Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia

Characterisation of a mouse cerebral microvascular endothelial cell line (bEnd.3) after oxygen glucose deprivation and reoxygenation.

Cloning and functional characterization of the guinea pig vanilloid receptor 1.

Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist.

Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints

Concurrent shear stress and chemical stimulation of mechano-sensitive cells by discontinuous dielectrophoresis

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function

Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse

Examination of the role of transient receptor potential vanilloid type 4 in endothelial responses to shear forces.

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular choroid plexus of the rat.

Expression of functional bradykinin receptors in Xenopus oocytes

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Glial cell line derived neurotrophic factor (GDNF) regulates VR1 and substance P in cultured sensory neurons

Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.

Immunology on chip: promises and opportunities.

Induction of gene amplification by 5-aza-2'-deoxycytidine

Influence of epitopes CD44v3 and CD44v6 in the invasive behavior of fibroblast-like synoviocytes derived from rheumatoid arthritic joints

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1.

Modulation of TRPV4 by diverse mechanisms

Modulation of the TRPV4 ion channel as a therapeutic target for disease

Molecular Sensors of Blood Flow in Endothelial Cells

Molecular studies on kinin receptors

Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists

Patents associated with high-cost drugs in Australia

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons.

Potent and orally bioavailable non-peptide antagonists at the human bradykinin B(1) receptor based on a 2-alkylamino-5-sulfamoylbenzamide core

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

Putative glycophorin-binding protein is secreted from schizonts of Plasmodium falciparum.

Regulation of bradykinin receptor gene expression in human lung fibroblasts

Selection of a cDNA clone which contains the complete coding sequence for the mature form of ornithine transcarbamylase from rat liver: expression of the cloned protein in Escherichia coli. Molecular cloning of rat ornithine transcarbamylase ⬇️

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

Shear Stress Regulates TRPV4 Channel Clustering and Translocation from Adherens Junctions to the Basal Membrane.

Shear stress mediates exocytosis of functional TRPV4 channels in endothelial cells

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation

Sites of action of ghrelin receptor ligands in cardiovascular control

Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability

The CD44v7/8 epitope as a target to restrain proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

The cDNA cloning and immunological characterization of hamster p53.

The primary structure of the imported mitochondrial protein, ornithine transcarbamylase from rat liver: mRNA levels during ontogeny

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo