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List of works by Tom H. Johnston

5-HT2A receptor levels increase in MPTP-lesioned macaques treated chronically with L-DOPA.

scientific article published on 18 June 2010

A critique of available scales and presentation of the Non-Human Primate Dyskinesia Rating Scale

scientific article published on 13 September 2012

A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates.

scientific article

A simple rodent assay for the in vivo identification of agents with potential to reduce levodopa-induced dyskinesia in Parkinson's disease

scientific article published in February 2005

Advances in the delivery of treatments for Parkinson's disease

scientific article

Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques

scientific article

Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism

scientific article published on 21 October 2010

Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice

scientific article

Changes in GABA(B) receptor mRNA expression in the rodent basal ganglia and thalamus following lesion of the nigrostriatal pathway.

scientific article

Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time.

scientific article

DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease

scientific article published on 29 November 2017

Dopamine D3 receptor stimulation underlies the development of L-DOPA-induced dyskinesia in animal models of Parkinson's disease.

scientific article

Dopamine receptor agonists and levodopa and inducing psychosis-like behavior in the MPTP primate model of Parkinson disease

scientific article published in September 2006

Drugs in development for Parkinson's disease.

scientific article

Drugs in development for Parkinson's disease: an update.

scientific article

Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease

scientific article published in July 2010

Experimental Models of l-DOPA-Induced Dyskinesia.

scientific article

Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease

scientific article published on 21 October 2010

Functional interaction between adenosine A2A and group III metabotropic glutamate receptors to reduce parkinsonian symptoms in rats.

scientific article published on 27 June 2008

GABA(B) receptor agonists reverse akinesia following intranigral or intracerebroventricular injection in the reserpine-treated rat.

scientific article published on August 2003

Generation of a model of L-DOPA-induced dyskinesia in two different mouse strains

scientific article published on 23 February 2011

Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease

scientific article published in June 2006

Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations

scientific article published on July 2010

Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease

scientific article published on 14 March 2012

L-745,870 reduces L-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease

scientific article published on 22 May 2012

L-745,870 reduces the expression of abnormal involuntary movements in the 6-OHDA-lesioned rat.

scientific article published in February 2015

L-DOPA pharmacokinetics in the MPTP-lesioned macaque model of Parkinson's disease

scientific article published on 18 June 2012

Neuropsychiatric behaviors in the MPTP marmoset model of Parkinson's disease.

scientific article published in January 2010

New insights into the organization of the basal ganglia

scientific article published on July 2009

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.

scientific article

Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia

scientific article published on 07 August 2018

Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease

scientific article published on 01 November 2006

Pioglitazone may impair L-DOPA anti-parkinsonian efficacy in the MPTP-lesioned macaque: results of a pilot study

scientific article

Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein

scientific article

RGFP109, a histone deacetylase inhibitor attenuates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: a proof-of-concept study

scientific article published on 14 August 2012

Receptor-activity modifying protein 1 expression is increased in the striatum following repeated L-DOPA administration in a 6-hydroxydopamine lesioned rat model of Parkinson's disease.

scientific article published in April 2008

Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease

scientific article published on 15 March 2010

Reproducibility of a Parkinsonism-related metabolic brain network in non-human primates: A descriptive pilot study with FDG PET.

scientific article

Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease

scientific article published on 01 June 2018

Rotigotine polyoxazoline conjugate SER-214 provides robust and sustained antiparkinsonian benefit

scientific article published on 03 September 2013

Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia.

scientific article published on 9 February 2005

TC-8831, a nicotinic acetylcholine receptor agonist, reduces L-DOPA-induced dyskinesia in the MPTP macaque

scientific article published on 14 June 2013

The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque

scientific article published on 10 June 2015

The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset.

scientific article

The nociceptin/orphanin FQ (NOP) receptor antagonist J-113397 enhances the effects of levodopa in the MPTP-lesioned nonhuman primate model of Parkinson's disease

scientific article

The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease

scientific article published on 10 January 2013

The selective mu-opioid receptor antagonist ADL5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in MPTP-lesioned macaque model of Parkinson's disease

scientific article published on 4 April 2011

The α₂ adrenergic antagonist fipamezole improves quality of levodopa action in Parkinsonian primates

scientific article published on October 2010

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque

scientific article

UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset

scientific article

Use of catechol-O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque

scientific article published on 3 January 2013

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