List of works - Ultan McDermott

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

scientific article

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

scientific article (publication date: 3 April 2014)

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

scientific article published on 01 September 2020

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

scientific article (publication date: 2 April 2010)

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

scientific article

A landscape of pharmacogenomic interactions in cancer.

scientific article published on 05 July 2016

A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma

scientific article published on 19 October 2018

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

scientific article published on 14 October 2016

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

A structure-guided approach to creating covalent FGFR inhibitors

scientific article

Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency

scientific article

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

scientific article published in Scientific Reports

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.

scientific article published on 4 February 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scientific article

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

scientific article published on 25 September 2017

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

scientific article published on 16 June 2016

BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib

scientific article published on 13 October 2014

Cancer cell lines as patient avatars for drug response prediction

scientific article published on 01 October 2018

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

scientific article

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity

scientific article published on 30 August 2018

Clinical significance of prognostic and predictive markers in colorectal cancer.

scientific article

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma

scientific article

Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition

scientific article

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

scientific article published on 2 November 2016

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on May 2016

Corrigendum: High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

article

Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer Using Formalin-Fixed Paraffin-Embedded Tissue

scientific article published on 07 November 2011

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.

scientific article published on 12 January 2011

EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION

scientific article published on 5 November 2018

Editorial overview: Cancer genomics: kill it. Kill it dead

scientific article published on 23 February 2014

Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer

scientific article published on October 2005

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

scientific article

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

scientific article published on June 2015

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

scholarly article by Colin S Cooper et al published June 2015 in Nature Genetics

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

scientific journal article

Exploiting genetic complexity in cancer to improve therapeutic strategies

scientific article

FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

scientific article published on 20 June 2016

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on 11 May 2015

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

article

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

scientific article published on 8 February 2017

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

scientific article published on August 2017

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

scientific article

Genomic determinants of protein abundance variation in colorectal cancer cells

Genomics and the continuum of cancer care

scientific article published on January 2011

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

scientific article

High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

scientific article published on 3 October 2017

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor

scientific article

Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling.

scientific article

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen

scientific article published on 10 March 2016

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

scholarly article

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia

scientific article published on 24 May 2019

Inactivating CUX1 mutations promote tumorigenesis

scientific article

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library

scientific article

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

scientific article

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

scientific article

Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer

scientific article published on 29 March 2022

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

scientific article published on 3 November 2015

Large-scale compound screens and pharmacogenomic interactions in cancer

scientific article published on 01 February 2019

Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors

scientific article published on 14 April 2009

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy

scientific article

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

scientific article published on 18 January 2018

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

scientific article published on 15 December 2014

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

scientific article

Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties

scientific article

Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.

scientific article

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study

scientific article published on 19 November 2019

Molecular diagnoses of century-old childhood tumours

scientific article published on 01 May 2017

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next-generation DNA sequencing.

scientific article

Mutational signatures of ionizing radiation in second malignancies

scientific article

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263

scientific article published on 17 September 2018

Next-generation sequencing and empowering personalised cancer medicine

scientific article

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

scientific article

P01.12 Stability of actionable mutations in primary and recurrent glioblastomas.

scientific article published on 19 April 2017

PATH-42. EGFR-AMPLIFIED IDH-WILDTYPE GLIOBLASTOMAS SELDOM TRANSFORM INTO A HYPERMUTATED PHENOTYPE

Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich.

scientific article published on 30 April 2018

Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology

scientific article published on 26 October 2009

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

scientific article published on 10 July 2015

Precision oncology for acute myeloid leukemia using a knowledge bank approach

scientific article

Predictive markers for colorectal cancer: current status and future prospects

scientific article

Processed pseudogenes acquired somatically during cancer development

scientific article published on 09 April 2014

Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer

scientific article

Prospective derivation of a living organoid biobank of colorectal cancer patients.

scientific article published on May 2015

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

scientific article published on May 2010

Reading between the lines; understanding drug response in the post genomic era.

scientific article

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

scientific article

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

scientific article

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

scientific article published on 16 April 2018

Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.

scientific article published on 20 November 2017

Societal challenges of precision medicine: Bringing order to chaos

scientific article published on 30 August 2017

Steps forward for cancer precision medicine

scientific article published on 24 November 2017

Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis

scientific article published on 31 March 2009

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

scientific article published on 21 February 2013

Targeting the RB-E2F pathway in breast cancer

scientific article

The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.

scientific article published in April 2018

The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens

scientific article

The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor

scientific article published in April 2008

The evolutionary history of lethal metastatic prostate cancer

scientific article published on April 2015

The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response

scientific article published on February 2014

The germline genetic component of drug sensitivity in cancer cell lines

scientific article published in Nature Communications

The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates

scientific article

The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites

scientific article

Time and frequency domain assessment of heart rate variability: a theoretical and clinical appreciation

scientific article published on April 1993

VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer

scientific article published on 27 December 2012

Whole exome sequencing of adenoid cystic carcinoma

scientific article published on 17 June 2013

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

scholarly article by Roelof J C Kluin published in October 2018

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

scientific article

ctDNA monitoring using patient-specific sequencing and integration of variant reads

scientific article published on 01 June 2020

List of works by Ultan McDermott

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

A landscape of pharmacogenomic interactions in cancer.

A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

A structure-guided approach to creating covalent FGFR inhibitors

Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib

Cancer cell lines as patient avatars for drug response prediction

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity

Clinical significance of prognostic and predictive markers in colorectal cancer.

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma

Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

Corrigendum: High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer Using Formalin-Fixed Paraffin-Embedded Tissue

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.

EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION

Editorial overview: Cancer genomics: kill it. Kill it dead

Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Erratum: Corrigendum: Signatures of mutational processes in human cancer

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

Exploiting genetic complexity in cancer to improve therapeutic strategies

FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

Genomic determinants of protein abundance variation in colorectal cancer cells

Genomics and the continuum of cancer care

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor

Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling.

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia

Inactivating CUX1 mutations promote tumorigenesis

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

Large-scale compound screens and pharmacogenomic interactions in cancer

Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties

Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study

Molecular diagnoses of century-old childhood tumours

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next-generation DNA sequencing.

Mutational signatures of ionizing radiation in second malignancies

NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263

Next-generation sequencing and empowering personalised cancer medicine

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

P01.12 Stability of actionable mutations in primary and recurrent glioblastomas.

PATH-42. EGFR-AMPLIFIED IDH-WILDTYPE GLIOBLASTOMAS SELDOM TRANSFORM INTO A HYPERMUTATED PHENOTYPE

Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich.