List of works - Chris D. Vulpe

A comparison between whole transcript and 3' RNA sequencing methods using Kapa and Lexogen library preparation methods

A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture

scientific article

A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis

scientific article published on 10 August 2009

A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.

scientific article published on March 2003

Aerosol droplet delivery of mesoporous silica nanoparticles: a strategy for respiratory-based therapeutics

journal article published in 2015

Age-related changes in iron homeostasis in mouse ferroxidase mutants

scientific article

Are X-linked cutis laxa and Menkes disease allelic?

scientific article published on 01 January 1993

Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians

scientific article published on 13 February 2013

Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations

scientific article

Biomarker discovery and transcriptomic responses in Daphnia magna exposed to munitions constituents.

scientific article

Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate

scientific article published on 25 June 2012

CAPRG: sequence assembling pipeline for next generation sequencing of non-model organisms

scientific article

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.

scientific article published on 31 May 2018

Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast

scientific article published on 27 July 2009

Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity.

scientific article published in February 2007

Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency

scientific article

Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.

scientific article published in July 2009

Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. ⬇️

scientific article published on October 2004

Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions

scientific article published on 13 December 2010

Discriminant analysis to evaluate clustering of gene expression data.

scientific article

Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins.

scientific article published in May 2008

Ecotoxicogenomics: Microarray interlaboratory comparability

scientific article published on 9 September 2015

Editor's Highlight: High-Throughput Functional Genomics Identifies Modulators of TCE Metabolite Genotoxicity and Candidate Susceptibility Genes

scientific article

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis

scientific article

Exploratory and confirmatory gene expression profiling of mac1Delta.

scientific article

Exploratory differential gene expression analysis in microarray experiments with no or limited replication

scientific article

Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis.

scientific article

Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans

scientific article

Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity

scientific article published on 01 May 2019

Functional Toxicogenomic Profiling Expands Insight into Modulators of Formaldehyde Toxicity in Yeast

scientific article (publication date: 2016)

Functional genomics indicates yeast requires Golgi/ER transport, chromatin remodeling, and DNA repair for low dose DMSO tolerance

scientific article published on 13 August 2013

Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast

scientific article

Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway

scientific article published on November 2003

Functional toxicogenomics: mechanism-centered toxicology. ⬇️

scientific article

Functional toxicology: tools to advance the future of toxicity testing

scientific article

Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals

scientific article

Gene expression profiling in Daphnia magna part I: concentration-dependent profiles provide support for the No Observed Transcriptional Effect Level.

scientific article published in August 2008

Gene expression profiling in Daphnia magna, part II: validation of a copper specific gene expression signature with effluent from two copper mines in California

scientific article published on August 2008

Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App.

scientific article

Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides).

scientific article published on 15 April 2014

Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants

scientific article (publication date: 16 June 2015)

Genetic Screens Reveal CCDC115 as a Modulator of Erythroid Iron and Heme Trafficking

scientific article published on 08 June 2020

Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde

scientific article published on 01 May 2019

Genome-wide association study identifies genetic loci associated with iron deficiency

scientific article

Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces cerevisiae

scientific article

Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast

scientific article (publication date: 2011)

Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but don't predict tissue iron levels in inbred mice

scientific article published on 10 August 2017

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

scientific article published on 01 September 2002

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.

scientific article published on 19 December 2016

Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.

scientific article published on 18 March 2015

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice

scientific article (publication date: 15 May 2004)

Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study

scientific article published on February 2010

How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α-ethinylestradiol to develop recommendations for environmental transcriptomics

scientific article

Identification of Genes Involved in the Toxic Response of Saccharomyces cerevisiae against Iron and Copper Overload by Parallel Analysis of Deletion Mutants

article

Identification of an intestinal heme transporter

scientific journal article

Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants

scientific article

Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells

scientific article

Impaired iron transport activity of ferroportin 1 in hereditary iron overload

scientific article

Imputing Phenotypes for Genome-wide Association Studies

scientific article published on 08 June 2016

In silico QTL mapping of basal liver iron levels in inbred mouse strains

scientific article

Incorporation of in situ exposure and biomarkers response in clams Ruditapes philippinarum for assessment of metal pollution in coastal areas from the Maluan Bay of China

scientific article

Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE

scientific article published on 01 August 2004

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium

scientific article

Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions

scientific article published on 25 July 2017

Intestinal iron absorption.

scientific article published on 08 May 2012

Investigations of transcript expression in fathead minnow (Pimephales promelas) brain tissue reveal toxicological impacts of RDX exposure

scientific article

Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity

scientific article

Iron deficiency upregulates Egr1 expression

scientific article published on 19 May 2015

Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.

scientific article published in September 2011

Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells.

scientific article

Iron-independent specific protein expression pattern in the liver of HFE-deficient mice

scientific article

Iron-overload-related disease in HFE hereditary hemochromatosis

scientific article

Ironing out anaemia

scientific article published on 01 August 1997

Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity

scientific article published on 31 October 2008

Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)

scientific article

Linking molecular biomarkers with higher level condition indicators to identify effects of copper exposures on the endangered delta smelt (Hypomesus transpacificus).

scientific article

Mammalian iron transport.

scientific article published on 31 May 2009

Metabolomics of microliter hemolymph samples enables an improved understanding of the combined metabolic and transcriptional responses of Daphnia magna to cadmium

scientific article

Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse

scientific article (publication date: February 2004)

Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke.

scientific article

Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism

scientific article

Molecular evidence for the role of a ferric reductase in iron transport

scientific article published on August 2002

Molecular toxicity identification evaluation (mTIE) approach predicts chemical exposure in Daphnia magna.

scientific article published on 7 October 2013

Multi-Copper Ferroxidase-Deficient Mice Have Increased Brain Iron Concentrations and Learning and Memory Deficits.

scientific article published in April 2018

Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans

scientific article

Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae

scientific article

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

scientific article published on 06 August 2019

Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells

scientific article (publication date: May 2016)

Plant copper chaperones.

scientific article published in August 2002

Prenatal diagnosis of Menkes disease by mutation analysis

scientific article

Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle

scientific article

Quantification of water solubilized CdSe/ZnS quantum dots in Daphnia magna.

scientific article

Regulatory motif finding by logic regression

scientific article published on 27 May 2004

Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption

scientific article published in 2002

Reverse engineering adverse outcome pathways

scientific article published in January 2011

SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis

scientific article

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin

scientific article published on 23 June 2018

Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation

scientific article

Silver nanowire exposure results in internalization and toxicity to Daphnia magna

scientific article

Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p

scientific article

Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency

scientific article (publication date: September 2003)

Systems Biology Approach Reveals a Calcium-Dependent Mechanism for Basal Toxicity in Daphnia magna.

scientific article published on 5 August 2015

The Toxicogenome of Hyalella azteca: A Model for Sediment Ecotoxicology and Evolutionary Toxicology

scientific article published on 10 April 2018

The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption.

scientific article

The mottled gene is the mouse homologue of the Menkes disease gene

scientific article published on April 1994

The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice

scientific article published on 4 June 2014

The role of duodenal cytochrome b in intestinal iron absorption remains unclear.

scientific article published on December 2005

Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis.

scientific article published in October 2004

Toward identifying the next generation of superfund and hazardous waste site contaminants

scientific article

Toxicogenomics of water chemistry influence on chronic lead exposure to the fathead minnow (Pimephales promelas).

scientific article

Transcriptomic and Network Analyses Reveal Mechanistic-Based Biomarkers of Endocrine Disruption in the Marine Mussel, Mytilus edulis

scientific article published on 28 June 2018

Using gene expression to assess the status of fish from anthropogenically influenced estuarine wetlands

scientific article published on 17 August 2011

List of works by Chris D. Vulpe

A comparison between whole transcript and 3' RNA sequencing methods using Kapa and Lexogen library preparation methods

A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture

A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis

A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.

Aerosol droplet delivery of mesoporous silica nanoparticles: a strategy for respiratory-based therapeutics

Age-related changes in iron homeostasis in mouse ferroxidase mutants

Are X-linked cutis laxa and Menkes disease allelic?

Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians

Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations

Biomarker discovery and transcriptomic responses in Daphnia magna exposed to munitions constituents.

Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate

CAPRG: sequence assembling pipeline for next generation sequencing of non-model organisms

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.

Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast

Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity.

Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency

Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.

Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. ⬇️

Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions

Discriminant analysis to evaluate clustering of gene expression data.

Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins.

Ecotoxicogenomics: Microarray interlaboratory comparability

Editor's Highlight: High-Throughput Functional Genomics Identifies Modulators of TCE Metabolite Genotoxicity and Candidate Susceptibility Genes

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis

Exploratory and confirmatory gene expression profiling of mac1Delta.

Exploratory differential gene expression analysis in microarray experiments with no or limited replication

Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis.

Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans

Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity

Functional Toxicogenomic Profiling Expands Insight into Modulators of Formaldehyde Toxicity in Yeast

Functional genomics indicates yeast requires Golgi/ER transport, chromatin remodeling, and DNA repair for low dose DMSO tolerance

Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast

Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway

Functional toxicogenomics: mechanism-centered toxicology. ⬇️

Functional toxicology: tools to advance the future of toxicity testing

Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals

Gene expression profiling in Daphnia magna part I: concentration-dependent profiles provide support for the No Observed Transcriptional Effect Level.

Gene expression profiling in Daphnia magna, part II: validation of a copper specific gene expression signature with effluent from two copper mines in California

Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App.

Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides).

Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants

Genetic Screens Reveal CCDC115 as a Modulator of Erythroid Iron and Heme Trafficking

Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde

Genome-wide association study identifies genetic loci associated with iron deficiency

Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces cerevisiae

Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast

Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but don't predict tissue iron levels in inbred mice

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.

Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice

Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study

How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α-ethinylestradiol to develop recommendations for environmental transcriptomics

Identification of Genes Involved in the Toxic Response of Saccharomyces cerevisiae against Iron and Copper Overload by Parallel Analysis of Deletion Mutants

Identification of an intestinal heme transporter

Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants

Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells

Impaired iron transport activity of ferroportin 1 in hereditary iron overload

Imputing Phenotypes for Genome-wide Association Studies

In silico QTL mapping of basal liver iron levels in inbred mouse strains

Incorporation of in situ exposure and biomarkers response in clams Ruditapes philippinarum for assessment of metal pollution in coastal areas from the Maluan Bay of China

Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium

Intestinal hephaestin potentiates iron absorption in weanling, adult, and pregnant mice under physiological conditions

Intestinal iron absorption.

Investigations of transcript expression in fathead minnow (Pimephales promelas) brain tissue reveal toxicological impacts of RDX exposure

Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity

Iron deficiency upregulates Egr1 expression

Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.

Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells.

Iron-independent specific protein expression pattern in the liver of HFE-deficient mice

Iron-overload-related disease in HFE hereditary hemochromatosis

Ironing out anaemia

Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity

Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)

Linking molecular biomarkers with higher level condition indicators to identify effects of copper exposures on the endangered delta smelt (Hypomesus transpacificus).

Mammalian iron transport.

Metabolomics of microliter hemolymph samples enables an improved understanding of the combined metabolic and transcriptional responses of Daphnia magna to cadmium

Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse