List of works - Julien Ochala

A myopathy-related actin mutation increases contractile function ⬇️

scientific article published on February 23, 2012

Aberrant post-translational modifications compromise human myosin motor function in old age.

scientific article

Changes in mechanical properties of human plantar flexor muscles in ageing

scientific article published on 01 March 2004

Changes in muscle and joint elasticity following long-term strength training in old age

scientific article published on 10 May 2006

Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction

scientific article published on 2 February 2018

Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms.

scientific article

Current and future therapeutic approaches to the congenital myopathies.

scientific article published on 8 August 2016

Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation

scientific article published on 17 April 2008

Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

scientific article published on 28 August 2018

Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy.

scientific article published on 24 February 2011

Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy.

scientific article

Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

scientific article published on 20 July 2016

EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

scientific article published on 02 October 2009

Effect of PGC1-beta ablation on myonuclear organisation

scientific article published on 01 December 2019

Effect of strength training on musculotendinous stiffness in elderly individuals

scientific article published on 09 February 2005

Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres

scientific article published on 01 February 2008

Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

scientific article published on 7 November 2016

Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model

scientific article

Gene expression and muscle fiber function in a porcine ICU model

scientific article published on 25 August 2009

Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle

scientific article

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

scientific article published on 19 June 2019

Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin

scientific article

Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model

scientific article published on 18 October 2011

Modulating myosin restores muscle function in a mouse model of nemaline myopathy

scientific article published on 17 February 2016

Molecular Consequences of the Myopathy-Related D286G Mutation on Actin Function

scientific article published on 04 December 2018

Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb

scientific journal article

Myofilament lattice structure in presence of a skeletal myopathy-related tropomyosin mutation

scientific article

Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

scientific article published on 22 April 2016

Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice.

scientific article published on 23 December 2017

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

scientific article published on 17 February 2020

Novel myosin-based therapies for congenital cardiac and skeletal myopathies

scientific article

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

scientific article published on 08 December 2020

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

scientific article

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms

scientific article published on 14 February 2011

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

scientific article published on 04 October 2018

Reducing dynamin 2 (DNM2) rescues -related dominant centronuclear myopathy

article published in the Proceedings of the National Academy of Sciences of the United States of America

Relationship between force and size in human single muscle fibres ⬇️

scientific article published on February 11, 2011

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.

scientific article

SIRT1 regulates nuclear number and domain size in skeletal muscle fibers.

scientific article published on 25 March 2018

Sexually dimorphic myofilament function in a mouse model of nemaline myopathy

scientific article published on 24 September 2014

Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old age

scientific article published on 19 April 2006

Skeletal and cardiac α-actin isoforms differently modulate myosin cross-bridge formation and myofibre force production.

scientific article

Skeletal muscle: a brief review of structure and function

scientific article

Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

scientific article published on 24 December 2012

The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q.

scientific article published on 18 January 2013

The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles

scientific article

Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction.

scientific article published on 24 June 2008

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.

scientific article

X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction.

scientific article published on 25 September 2015

rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy

scientific article published on 19 October 2020

List of works by Julien Ochala

A myopathy-related actin mutation increases contractile function ⬇️

Aberrant post-translational modifications compromise human myosin motor function in old age.

Changes in mechanical properties of human plantar flexor muscles in ageing

Changes in muscle and joint elasticity following long-term strength training in old age

Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction

Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms.

Current and future therapeutic approaches to the congenital myopathies.

Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation

Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy.

Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy.

Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

Effect of PGC1-beta ablation on myonuclear organisation

Effect of strength training on musculotendinous stiffness in elderly individuals

Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres

Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model

Gene expression and muscle fiber function in a porcine ICU model

Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin

Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model

Modulating myosin restores muscle function in a mouse model of nemaline myopathy

Molecular Consequences of the Myopathy-Related D286G Mutation on Actin Function

Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb

Myofilament lattice structure in presence of a skeletal myopathy-related tropomyosin mutation

Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice.

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

Novel myosin-based therapies for congenital cardiac and skeletal myopathies

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

Reducing dynamin 2 (DNM2) rescues -related dominant centronuclear myopathy

Relationship between force and size in human single muscle fibres ⬇️

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.

SIRT1 regulates nuclear number and domain size in skeletal muscle fibers.

Sexually dimorphic myofilament function in a mouse model of nemaline myopathy

Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old age

Skeletal and cardiac α-actin isoforms differently modulate myosin cross-bridge formation and myofibre force production.

Skeletal muscle: a brief review of structure and function

Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q.

The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles

Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction.

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.

X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction.

rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy