List of works - Paulo Pereira

7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells

scientific article

7-ketocholesterol stimulates differentiation of lens epithelial cells.

scientific article published on 6 October 2003

A Technical Approach to the Evaluation of Glucose Oxidation: Implications for Diabetic Cataract

scientific article published on 01 January 1996

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

scientific article published on 28 July 2014

Accelerated age-related olfactory decline among type 1 Usher patients.

scientific article published on 22 June 2016

Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation.

scientific article

Age-related accumulation of free polyunsaturated fatty acids in human retina

scientific article published on 01 January 1999

Age-related changes in normal and cataractous human lens crystallins, separated by fast-performance liquid chromatography

scientific article published on 01 January 1994

An experimental model for the evaluation of lipid peroxidation in lens membranes

scientific article published on 01 April 1996

Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid.

scientific article published on 10 April 2013

Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia

scientific article

Autophagy and ubiquitination in cardiovascular diseases

scientific article

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

scientific journal article

Bendazac decreasesin vitro glycation of human lens crystallins

scientific article published on 01 January 1995

Cholesterol Oxides Accumulate in Human Cataracts

scientific article published on 01 May 1998

Cholesterol may act as an antioxidant in lens membranes

scientific article published on 01 June 1999

Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases.

scientific article published on December 2003

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive

scientific article published on June 2015

Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.

scientific article published on 8 October 2015

Crystallin composition of human cataractous lens may be modulated by protein glycation

scientific article published on 01 August 1996

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.

scientific article published on 29 November 2013

Diabetes mellitus: new challenges and innovative therapies ⬇️

scientific article published on March 13, 2010

Downregulation of retinal GLUT1 in diabetes by ubiquitinylation.

scientific article published on 30 August 2004

Elucidation of the dynamic nature of interactome networks: A practical tutorial.

scientific article published on 19 April 2017

Evaluation of a non-invasive fluorescence technique as a marker for diabetic lenses in vivo

scientific article published in March 1999

Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons

scientific article published on 13 October 2012

Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis

scientific article published on 15 October 2019

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

scientific article published in September 2017

Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.

scientific article published on 4 March 2008

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

scientific article

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

scientific article published on 03 March 2015

High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism

scientific article

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

scientific article

Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus

scientific article published on 01 April 1999

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

scientific article

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

scientific article

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy.

scientific article published on 11 May 2015

LAMP2A regulates the loading of proteins into exosomes

scientific article published on 25 March 2022

Lens fibers have a fully functional ubiquitin-proteasome pathway

scientific article published in May 2003

Methylglyoxal alters the function and stability of critical components of the protein quality control

scientific article

Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity

scientific article published on 27 February 2012

Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats.

scientific article published on 30 April 2013

Methylglyoxal promotes oxidative stress and endothelial dysfunction

scientific journal article

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.

scientific article published on 18 June 2010

MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.

scientific article

Molecular control of chaperone-mediated autophagy

scientific article published on 12 December 2017

Oxidative damage to lens membranes induced by metal-catalyzed systems

scientific article published on 01 January 1996

Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.

scientific article

Oxidative stress upregulates ubiquitin proteasome pathway in retinal endothelial cells.

scientific article published on 5 December 2006

Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells.

scientific article

Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin

scientific article

Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes.

scientific article published on 26 May 2011

Regulation of the expression of interleukin‐8 induced by 25‐hydroxycholesterol in retinal pigment epithelium cells ⬇️

scientific article published on February 7, 2012

Role of glycation in human lens protein structure change.

scientific article

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

scientific journal article

Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation.

scientific article

The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal

scientific article

The proteasome regulates the interaction between Cx43 and ZO-1.

scientific article published on October 2007

The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells

scientific article published on 11 April 2008

The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

scientific article

To beat or not to beat: degradation of Cx43 imposes the heart rhythm

scientific article published on June 2015

Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

scientific article published on 9 July 2004

Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

scientific article published on 01 July 2011

Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

scientific article

List of works by Paulo Pereira

7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells

7-ketocholesterol stimulates differentiation of lens epithelial cells.

A Technical Approach to the Evaluation of Glucose Oxidation: Implications for Diabetic Cataract

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

Accelerated age-related olfactory decline among type 1 Usher patients.

Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation.

Age-related accumulation of free polyunsaturated fatty acids in human retina

Age-related changes in normal and cataractous human lens crystallins, separated by fast-performance liquid chromatography

An experimental model for the evaluation of lipid peroxidation in lens membranes

Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid.

Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia

Autophagy and ubiquitination in cardiovascular diseases

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

Bendazac decreasesin vitro glycation of human lens crystallins

Cholesterol Oxides Accumulate in Human Cataracts

Cholesterol may act as an antioxidant in lens membranes

Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases.

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive

Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.

Crystallin composition of human cataractous lens may be modulated by protein glycation

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.

Diabetes mellitus: new challenges and innovative therapies ⬇️

Downregulation of retinal GLUT1 in diabetes by ubiquitinylation.

Elucidation of the dynamic nature of interactome networks: A practical tutorial.

Evaluation of a non-invasive fluorescence technique as a marker for diabetic lenses in vivo

Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons

Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy.

LAMP2A regulates the loading of proteins into exosomes

Lens fibers have a fully functional ubiquitin-proteasome pathway

Methylglyoxal alters the function and stability of critical components of the protein quality control

Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity

Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats.

Methylglyoxal promotes oxidative stress and endothelial dysfunction

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.

MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.

Molecular control of chaperone-mediated autophagy

Oxidative damage to lens membranes induced by metal-catalyzed systems

Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.

Oxidative stress upregulates ubiquitin proteasome pathway in retinal endothelial cells.

Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells.

Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin

Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes.

Regulation of the expression of interleukin‐8 induced by 25‐hydroxycholesterol in retinal pigment epithelium cells ⬇️

Role of glycation in human lens protein structure change.

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation.

The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal

The proteasome regulates the interaction between Cx43 and ZO-1.

The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells

The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

To beat or not to beat: degradation of Cx43 imposes the heart rhythm

Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice