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List of works by Freda K. Stevenson

A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidis.

scientific article published on 29 October 2007

A gamma Bence-Jones protein in guinea pigs ⬇️

scientific article published on December 1, 1975

A gamma-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope

scientific article published in December 2002

A genetic approach to idiotypic vaccination

scientific article published in November 1993

A genetic approach to idiotypic vaccination for B cell lymphoma

scientific article published on November 1995

A human b-cell lymphoma synthesizing and expressing surface mu-chain in the absence of detectable light chain

scientific article published in September 1981

A human monoclonal antibody encoded by the V4-34 gene segment recognises melanoma-associated ganglioside via CDR3 and FWR1.

scientific article published on January 1999

A phase-II trial of recombinant interleukin-2 and 5-FU chemotherapy in patients with metastatic colorectal carcinoma

scientific article

A pilot study of idiotypic vaccination for follicular B-cell lymphoma using a genetic approach. CRC NO: 92/33. Protocol NO: PH1/027.

scientific article

A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer

scientific article published on 22 April 2016

Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma

scientific article

Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin

scientific article published on 29 May 2009

An analogue peptide from the Cancer/Testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide

scientific article

Analysis of Ig VH region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma

scientific article published on May 1995

Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.

scientific article published in June 1998

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

scientific article published in April 1995

Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events

scientific article published on December 1999

Analysis of immunoglobulin variable region genes of a human IgM anti-myeloperoxidase antibody derived from a patient with vasculitis.

scientific article published in February 1996

Analysis of soluble HLA Class II antigenic material in patients with immunological diseases using monoclonal antibodies

scientific article published in February 1986

Anti-idiotype sera raised against surface immunoglobulin of human neoplastic lymphocytes

scientific article

Anti-idiotype vaccines

scientific article published on December 2003

Anti-idiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin

scientific article published in July 1990

Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1

scientific article published on 15 January 1987

Anti-idiotypic therapy of leukemias and lymphomas.

scientific article published on January 1990

Anti-j: Human Cold Agglutinins Recognizing Linear (i) and Branched (I) Type 2 Chains

scientific article published in August 1994

Antibodies against urinary light chain idiotypes as agents for detection and destruction of human neoplastic B lymphocytes

scientific article published in December 1983

Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors

article

Antibody activity in the presence of urea or guanidine ⬇️

scientific article published on 18 January 1967

Antibody to a molecularly-defined antigen confined to a tumour cell surface ⬇️

scientific article published on April 24, 1975

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma

scientific article published in August 1994

Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment

scientific article published on 15 July 1993

Autoantibodies revealed: the role of B cells in autoimmune disease

scientific article published in July 1999

B Cells Producing Pathogenic Autoantibodies

scientific article published in 2004

B cell maturation in relation to multiple myeloma

scientific article

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

scientific article published on 01 February 2022

B-cell receptor signaling in chronic lymphocytic leukemia.

scientific article published on 3 August 2011

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

Biased utilization of immunoglobulin variable region heavy- and light-chain genes by the malignant CD5- B lymphocytes from patients with Burkitt's lymphoma.

scientific article published in July 1994

Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

scientific article

Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid

scientific article published in April 2010

CD3+ CD8+ T cell lymphocytosis masking B cell leukaemia

scientific article published on July 1988

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.

scientific article

Cancer Vaccines

scientific article published in 2007

Celebrating 20 Years of IGHV Mutation Analysis in CLL

scientific article published on 22 January 2020

Characterisation of a light chain loss variant of the BCL1 lymphoma

scientific article published in July 1991

Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC.

scientific article published on December 2002

Chronic lymphocytic leukaemia

article

Chronic lymphocytic leukaemia

scientific article published on 09 February 2017

Chronic lymphocytic leukaemia and normal B lymphopoiesis

scientific article published in March 1984

Chronic lymphocytic leukemia: revelations from the B-cell receptor.

scientific article published on 12 February 2004

Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes

scientific article published in March 1994

Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation

scientific article published on October 1998

Cold agglutinin activity is common among human monoclonal IgM Rh system antibodies using the V4-34 heavy chain variable gene segment

scientific article published in November 1997

Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection

scientific article

Comparison of serum and synovial fluid concentrations of beta 2-microglobulin and C reactive protein in relation to clinical disease activity and synovial inflammation in rheumatoid arthritis

scientific article

Consumption of monoclonal anti-idiotypic antibody by neoplastic B lymphocytes: a guide for immunotherapy

scientific article published on September 1984

Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus

scientific article

Critical Components of a DNA Fusion Vaccine Able to Induce Protective Cytotoxic T Cells Against a Single Epitope of a Tumor Antigen

scientific article published in October 2002

Critical influences on the pathogenesis of follicular lymphoma

scientific article published on 17 April 2018

Cross-linking of lymphocytic surface immunoglobulin inhibits its production via a cyclic nucleotide mechanism ⬇️

scientific article published on September 27, 1979

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

scientific article published on 03 June 2021

DNA Fusion Vaccine Designed to Induce Cytotoxic T Cell Responses Against Defined Peptide Motifs: Implications for Cancer Vaccines

scientific article published in August 2001

DNA Fusion Vaccines Against B-Cell Tumors

scientific article published on 01 January 2000

DNA Fusion Vaccines Induce Epitope-Specific Cytotoxic CD8+ T Cells against Human Leukemia-Associated Minor Histocompatibility Antigens

scientific article published on 15 May 2006

DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire

scientific article published on August 2008

DNA fusion gene vaccines against cancer: from the laboratory to the clinic.

scientific article published in June 2004

DNA fusion gene vaccines induce cytotoxic T-cell attack on naturally processed peptides of human prostate-specific membrane antigen.

scientific article published on 4 July 2011

DNA fusion vaccine designs to induce tumor-lytic CD8+ T-cell attack via the immunodominant cysteine-containing epitope of NY-ESO 1.

scientific article published on 11 April 2013

DNA fusion vaccines against B-cell tumors

scientific article published in December 2001

DNA fusion vaccines enter the clinic.

scientific article published on 05 June 2011

DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoire

scientific article published on October 2004

DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time

scientific article published on 22 May 2012

DNA gene fusion vaccines against cancer

scientific article

DNA vaccination against cancer antigens

scientific article

DNA vaccination against multiple myeloma.

scientific article published in January 1999

DNA vaccination as cancer immunotherapy

scientific article published in May 1997

DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance

scientific article

DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer

scientific article published on November 2009

DNA vaccination: a potential weapon against infection and cancer.

scientific article

DNA vaccines against cancer come of age.

scientific article published on 19 February 2010

DNA vaccines against cancer: from genes to therapy.

scientific article

DNA vaccines against haematological malignancies

scientific article

DNA vaccines against lymphoma: promotion of anti-idiotypic antibody responses induced by single chain Fv genes by fusion to tetanus toxin fragment C

scientific article published on 15 August 1997

DNA vaccines and adjuvants

scientific article published in June 2004

DNA vaccines to attack cancer

scholarly article

DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma

scientific article published in November 1998

DNA vaccines: precision tools for activating effective immunity against cancer.

scientific article published on February 2008

Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells

scientific article published on 2 November 2004

Determining mutational status of immunoglobulin v genes in chronic lymphocytic leukemia: a useful prognostic indicator

article

Developing a measure for the appropriateness of prescribing in general practice

scientific article

Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities

scientific article published in June 1997

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

scientific article published on 26 September 2002

Differential usage of an Ig heavy chain variable region gene by human B-cell tumors

scientific article published in July 1993

Differential usage of an autoantibody-associated VH gene, VH4-21, by human B-cell tumors

scientific article published on February 1995

Disturbances in peripheral blood B cell subpopulations in autoimmune patients

scientific article

Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene. A possible link between infection and lupus

scientific article published in September 1995

Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: A possible link between infection and lupus

scientific article published in June 1995

Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus.

scientific article published in January 1995

ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia

article

Early stages in the ontogeny of small B-cell lymphomas: genetics and microenvironment.

scientific article published on 10 April 2017

Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen

scientific article

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

scientific article published on 21 October 2015

Engineering DNA vaccines that include plant virus coat proteins.

scientific article published on January 2003

Evaluation of the VP22 protein for enhancement of a DNA vaccine against anthrax

scientific article

Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen

scientific article

Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

scientific article published on June 1995

Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.

scientific article published on October 1996

Exploring the pathways to chronic lymphocytic leukemia

Expression of anti-DNA antibodies.

scientific article published on January 1997

Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif

scientific article

Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes

scientific article published on December 1980

Failure of vaccination with idiotypic protein or DNA, (+/-IL-2), the depletion of regulatory T cells, or the blockade of CTLA-4 to prolong dormancy in mice with BCL1 lymphoma

scientific article published on November 2005

Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

scientific article

Follicular lymphoma and the immune system: from pathogenesis to antibody therapy ⬇️

scientific article published on February 15, 2012

Further studies of immunoglobulin synthesis by guinea pig leukaemic lymphocytes ⬇️

scientific article published on May 1, 1978

Genetic Vaccines against Cancer

scientific article published in 2013

Genetic analysis of IgE.

scientific article published on May 1996

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

scientific article

Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch

scientific article

Harnessing innate immunity to suppress lymphoma

scientific article published on 09 August 2010

Heterogeneity in neoplastic cell populations in chronic lymphocytic leukaemia defined by immunoglobulin expression and secretion in vitro

scientific article published in January 1988

Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic

scientific article published in April 2001

High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen

scientific article published on 25 May 2011

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

scientific article published on 6 March 2015

Hodgkin's Disease — New Insights from Immunoglobulin Genetics

scientific article published on 5 October 1995

Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells.

scientific article published on November 1993

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.

scientific article published on 29 December 2006

Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope

scientific article published on October 1991

Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region

scientific article published in January 1998

Humoral effector mechanisms in the immunity to cancer

scientific article published in January 1990

IDENTIFICATION OF THE 9G4 IDIOTOPE IN SYSTEMIC LUPUS ERYTHEMATOSUS

scientific article published in 1993

IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution

scientific article published on 01 March 2020

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

scientific article published on 28 November 2016

IL-4 enhances expression and function of surface IgM in CLL cells.

scientific article

Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients

scientific article published on 29 October 2018

Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma

scientific article published in January 2005

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

scientific article

Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity

scientific article published in May 1989

Idiotype gene rescue in follicular lymphoma

article

Idiotype vaccination leads to the emergence of a stable surface Ig-negative variant of the mouse lymphoma BCL1, with different growth characteristics

scientific article published in March 1988

Idiotypes and diseases

scientific article published in October 1986

Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study

scientific article published on 16 May 2015

Idiotypic DNA vaccines against B-cell lymphoma

scientific article

Idiotypic IgM on a B-cell surface requires processing for recognition by anti-idiotypic T cells

scientific article published on April 1993

Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes: a therapeutic target

scientific article

Idiotypic vaccination against B-cell lymphoma leads to dormant tumour

scientific article published in January 1991

Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines

scientific article published in June 1994

Idiotypic vaccination as a treatment for a B cell lymphoma

scientific article published on 15 September 1988

Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance.

scientific article published in January 1996

Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses

scientific article published on 8 November 2010

IgG-secreting lymphoplasmacytoid leukaemia: a B-cell disorder with extensively mutated VH genes undergoing Ig isotype-switching frequently associated with trisomy 12.

scientific article published in April 2000

IgM-expressing Waldenstrom's macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo

scientific article published on 8 February 2007

Immunization with idiotypic immunoglobulin protects against development of B lymphocytic leukemia, but emerging tumor cells can evade antibody attack by modulation

scientific article published in February 1983

Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis

scientific article published in April 1998

Immunogenetic analysis of the heavy chain variable regions of IgE from patients allergic to peanuts.

scientific article published on March 1998

Immunogenetic analysis of the immune response to pneumococcal polysaccharide

scientific article

Immunogenetic analysis reveals that epitope shifting occurs during B-cell affinity maturation in primary biliary cirrhosis

scientific article

Immunogenetics of human IgE

scientific article published in December 1996

Immunogenetics of human IgE.

scientific article published on January 1996

Immunoglobulin V genes and CD38 expression in CLL

scientific article published in April 2000

Immunoglobulin VH gene sequence analysis of spontaneous murine immunoglobulin-secreting B-cell tumours with clinical features of human disease

scientific article published on February 1998

Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines

scientific article published on April 2006

Immunoglobulin negative follicle centre cell lymphoma

scientific article published on December 1984

Immunoglobulin produced by guinea-pig leukaemic B lymphocytes: its source and use as a monitor of tumour load

scientific article

Immunotherapy for multiple myeloma: insights from other models

scientific article published in April 2002

Immunotherapy of hematologic malignancy.

scientific article published on January 2003

In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study

scientific article

Incidence of novel N-glycosylation sites in the B-cell receptor of lymphomas associated with immunodeficiency.

scientific article published in March 2004

Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt's lymphoma and mucosa-associated lymphoid tissue lymphoma

scientific article published on 01 January 2003

Inhibition of a vaccine-induced anti-tumor B cell response by soluble protein antigen in the absence of continuing T cell help

scientific article

Initial experience in treating human lymphoma with a chimeric univalent derivative of monoclonal anti-idiotype antibody

scientific article published in March 1987

Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis

scientific article published in July 1998

Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes

scientific article

Insight into the potential for DNA idiotypic fusion vaccines designed for patients by analysing xenogeneic anti-idiotypic antibody responses

article

Interactive health communication applications for chronic disease: Patient and carer perspectives

article

Introduction to a review series on advances in cell-based immune therapeutics in hematology

scientific article published on 20 May 2016

Introduction to a review series on biological insights into lymphoid tumors

scientific article published on 17 April 2018

Introduction to a review series on therapeutic antibodies

scientific article published on 8 November 2017

Introduction to a review series on understanding and treating primary immunodeficiency

scientific article published on 01 February 2020

Introduction: immunotherapy for multiple myeloma--insights and advances

scientific article published in January 1999

Intronic BCL-6 mutations are preferentially targeted to the translocated allele in t(3;14)(q27;q32) non-Hodgkin B-cell lymphoma

scientific article published in September 2003

Involvement of innate and induced anti-idiotypic mechanisms in suppression of B cell tumors

scientific article published in 1987

Isolation and EBV-transformation of a minor population of normal human tonsillar B cells bearing a cold agglutinin-associated idiotope

scientific article published on December 1990

Isotype switch variants reveal clonally related subpopulations in diffuse large B-cell lymphoma

Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells.

scientific article published on 20 July 2015

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

scientific article published on 17 March 2015

Lineage complexity in multiple myeloma?

scientific article published in January 2006

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.

scientific article published on 12 January 2018

Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination

scientific article published on 5 October 2016

Lymphokine-activated killer cells from normal and lymphoma subjects are cytotoxic for cells coated with antibody derivatives displaying human Fc gamma

scientific article published in December 1988

Lymphoma in Sjögren's syndrome: urinary monoclonal free light chains as a diagnostic aid and a means of tumour monitoring

scientific article published in 1986

Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines

scientific article published in August 1999

Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events

scientific article published on 9 October 2003

Measuring the appropriateness of prescribing in primary care: are current measures complete?

scientific article published on 01 December 2005

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

scientific article

Mechanisms of tumour cell escape encountered in treating lymphocytic leukaemia with anti-idiotypic antibody

scientific article

Mediation of cytotoxic functions by classes and subclasses of sheep antibody reactive with cell surface immunoglobulin idiotypic and constant region determinants

scientific article published on February 1978

Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment

scientific article

Molecular vaccines in infection and cancer

scientific article published in April 1996

Molecular vaccines in infection and cancer

scientific article

Monoclonal anti-light chain idiotype as a tumor-specific probe for human neoplastic B lymphocytes

scientific article published in March 1987

Monoclonal antibodies raised against the idiotype of the murine B cell lymphoma, BCL1 act primarily with heavy chain determinants

scientific article published in April 1991

Monoclonal immunoglobulin light chain in urine of patients with B lymphocytic disease: its source and use as a diagnostic aid.

scientific article

Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells.

scientific article published in January 1997

New strategies for vaccination and imunomodulation in NHL.

scientific article

Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype

scientific article

Optimizing cancer immunotherapy trials: back to basics.

scientific article

Origins of the malignant clone in typical Waldenstrom's macroglobulinemia

scientific article published in April 2003

PASD1 is a potential multiple myeloma-associated antigen

scientific article published in December 2006

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

scientific article published on 27 August 2016

PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia.

scientific article published on 19 October 2003

Pattern of usage and somatic hypermutation in the V(H)5 gene segments of a patient with asthma: implications for IgE.

scientific article published on January 1997

Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching.

scientific article

Pattern of usage of the VH4–21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching

scientific article published in April 1995

Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma.

scientific article published on 16 January 2003

Peripheral blood stem cell autografts in myeloma

scientific article published in January 1990

Phage surface expression for analysis of recognition sites of human autoantibodies: comparison of single chain Fv and Fab.

scientific article published in January 1997

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

scientific article published on 21 August 2006

Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition

scientific article published on 28 October 2014

Plant viral genes in DNA idiotypic vaccines activate linked CD4+ T-cell mediated immunity against B-cell malignancies

scientific article published in August 2001

Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody

scientific article

Polycythaemia rubra vera and hairy cell leukaemia in the same patient: studies on the spleen.

scientific article

Polycythemia rubra vera and hairy cell leukemia

scientific article published in 1985

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

scientific article published on 12 December 2019

Preliminary experience in treating lymphocytic leukaemia with antibody to immunoglobulin idiotypes on the cell surfaces

scientific article published on October 1980

Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody

scientific article published on March 1991

Preparation and properties of FabIgG, a chimeric univalent antibody designed to attack tumour cells

scientific article published in 1985

Preparing the ground for vaccination against multiple myeloma

scientific article published in April 2000

Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development

scientific article published on 18 December 2008

Prime-Boost with Alternating DNA Vaccines Designed to Engage Different Antigen Presentation Pathways Generates High Frequencies of Peptide-Specific CD8+ T Cells

scientific article published on 2 November 2006

Problems and prospects in the use of lymphoma idiotypes as therapeutic targets

scientific article published in 1988

Prolonged antigen expression following DNA vaccination impairs effector CD8+ T cell function and memory development

scientific article published in December 2007

Prospects for the treatment of B cell tumors using idiotypic vaccination

scientific article published on January 1989

Protein-polysaccharide complexes secreted by the calf tracheal epithelium in vitro

scientific article published on October 1969

Proteomic analysis of chronic lymphocytic leukemia subtypes with mutated or unmutated Ig V(H) genes

scientific article

Public T cell receptor beta-chains are not advantaged during positive selection

scientific article published in January 2008

Quantitative determination of xylose in mucopolysaccharide derivatives

scientific article published on 29 April 1967

Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies

scientific article published on July 1996

Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies, II.

scientific article published on April 1997

Recognition of a B cell lymphoma by anti-idiotypic T cells

scientific article published in December 1990

Recognition of auto- and exoantigens by V4-34 gene encoded antibodies

scientific article

Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma

scientific article published on 19 November 2007

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

scientific article published on 15 May 2007

Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V(H)-gene is unmutated?

scientific article published in April 2004

Secretion of idiotypic IgM by the mouse B-cell leukaemia (BCL1) occurs spontaneously in vitro and in vivo

scientific article published in May 1985

Secretion of immunoglobulin by neoplastic B lymphocytes from lymph nodes of patients with lymphoma ⬇️

scientific article published on November 1, 1984

Selective expression of a VHIV subfamily of immunoglobulin genes in human CD5+ B lymphocytes from cord blood

scientific article published on July 1991

Sequence analysis of V(4-34)-encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE).

scientific article published in October 1998

Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue.

scientific article

Soluble histocompatibility antigens in synovial fluids of patients with rheumatoid arthritis

scientific article published on April 1990

Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia

scientific article published in June 2000

Some effects on leukaemic B lymphocytes of antibodies to defined regions of their surface immunoglobulin ⬇️

scientific article published on April 1, 1977

Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes

scientific article published on 15 March 1995

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

scientific article

Structural analysis of VH4-21 encoded human IgM allo- and autoantibodies against red blood cells

scientific article published on July 1995

Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia.

scientific article

Studies on the cell surface maltase of the rabbit renal cortex

scientific article published in July 1973

Subunits of Tamm-Horsfall glycoprotein

scientific article published on March 1970

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

scientific article published on 14 June 2016

Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

scientific article published on 17 March 2010

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.

scientific article

Surface immunoglobulin of guinea-pig leukaemic lymphocytes

scientific article

Synergistic cytotoxic effects of antibodies directed against different cell surface determinants

scientific article

Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

scientific article published in February 2008

Targeting B-cell anergy in chronic lymphocytic leukemia.

scientific article published on 4 March 2013

Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.

scientific article published on 18 April 2016

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

scientific article published on 3 October 2016

The I Binding Specificity of Human VH4-34 (VH4-21) Encoded Antibodies is Determined by Both VHFramework Region 1 and Complementarity Determining Region 3

scientific article published in March 1996

The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.

scientific article published on 10 January 2012

The Immunoglobulin VHGene, VH4-21, Specifically Encodes Autoanti-Red Cell Antibodies against the I or i Antigens

scientific article published in May 1995

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

scientific article published on 8 May 2015

The disaccharidase activity of a membrane fraction obtained from the rabbit renal cortex

scientific article published in April 1972

The effect of ions on the viscometric and ultracentrifugal behaviour of Tamm-Horsfall glycoprotein

scientific article published on 27 April 1971

The effect of ions on the viscometric and ultracentrifugal behaviour of Tamm-Horsfall glycoprotein

scientific article published in April 1971

The export of immunoglobulin D by human neoplastic B lymphocytes

scientific article published on January 1983

The genetic basis of human VH4 gene family-associated cross-reactive idiotype expression in CD5+ and CD5- cord blood B-lymphocyte clones

scientific article published on October 1993

The immunological demonstration of an association between maltase activity and proximal tubular cell borders in the rabbit kidney

scientific article published in September 1972

The immunological demonstration of an association between maltase activity and proximal tubular cell borders in the rabbit kidney

scholarly article by Freda K. Stevenson published 1 September 1972 in Biochimica et Biophysica Acta

The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia.

scientific article

The nature of the immunoglobulin G on the surface of B lymphocytes in chronic lymphocytic leukemia

scientific article published on December 1981

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

scientific article published on 3 November 2009

The occurrence and significance of V gene mutations in B cell-derived human malignancy

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The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

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The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells

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The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia.

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The viscosity of Tamm-Horsfall mucoprotein ⬇️

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The viscosity of tamm-horsfall mucoprotein and its relation to cystic fibrosis ⬇️

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Therapeutic strategies for B cell malignancies involving idiotype-anti-idiotype interactions

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Tracking of the V4-34 (VH4-21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of somatic hypermutation

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Treatment of lymphoid tumors with anti-idiotype antibodies

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Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing

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Tumor vaccines

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Tumor vaccines.

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Turning genes into cancer vaccines

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Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events

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Understanding and activating immunity against human cancer

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Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event?

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Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

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Update on cancer vaccines.

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Update on tumor vaccines

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Urinary excretion of CD23 antigen in normal individuals and patients with chronic lymphocytic leukaemia (CLL)

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Urinary monoclonal free light chains in primary Sjögren's syndrome: an aid to the diagnosis of malignant lymphoma

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Use of Phage Expression to Analyze Regions of a Human V4-34(VH4-21)-encoded IgG Autoantibody Required for Recognition of DNA No Involvement of the 9G4 Idiotope

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Use of a cross reacting anti-idiotype to identify normal counterparts of neoplastic cells

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Use of a phage expression system to produce Fabs from human autoanti-DNA antibodies encoded by the VH4-21 gene segment

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Use of phage surface expression to analyze regions of human V4-34(VH4-21)-encoded IgG autoantibody required for recognition of DNA: no involvement of the 9G4 idiotope

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Use of strategies to improve retention in primary care randomised trials: a qualitative study with in-depth interviews.

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Utilization of the VH4-21 Gene Segment by Anti-DNA Antibodies from Patients with Systemic Lupus Erythematosus

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V(H) gene analysis of IgM-secreting myeloma indicates an origin from a memory cell undergoing isotype switch events

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V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity

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VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection

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VH gene analysis of Burkitt's lymphoma in children from north-western Iran

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VH gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG.

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VH gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo

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VH gene sequences from a novel tropical splenic lymphoma reveal a naive B cell as the cell of origin.

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VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

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VP22 enhances antibody responses from DNA vaccines but not by intercellular spread

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Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells

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Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific

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Vaccination with DNA encoding a single-chain TCR fusion protein induces anticlonotypic immunity and protects against T-cell lymphoma

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Vaccine therapy in NHL: future promises and current limitations

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What is the CLL B-lymphocyte?

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Whole ricin and recombinant ricin A chain idiotype-specific immunotoxins for therapy of the guinea pig L2C B cell leukemia

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beta2-Microglobulin from Normal and Leukaemic Guinea-Pig Lymphocytes ⬇️

scientific article published on January 1, 1978

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