List of works by Jean-Luc Villeval

A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors

scientific article published on 01 January 1986

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.

scientific article

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

scientific article published in January 2003

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

scientific article (publication date: 28 April 2005)

Activating mutations in human acute megakaryoblastic leukemia.

scientific article

Acute myelofibrosis in megakaryoblastic leukemia with translocation between chromosomes 8 and 14

scientific article published on 01 November 1987

Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development

article

Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factor

scientific article

Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.

scientific article

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.

scientific article published on October 1994

Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro

scientific article

BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features

scientific article published in November 2008

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

scientific article published on 25 November 2015

Carbonic anhydrase I is an early specific marker of normal human erythroid differentiation

scientific article published on 01 November 1985

Changes in hemopoietic and regulator levels in mice during fatal or nonfatal malarial infections. I. Erythropoietic populations

scientific article published in November 1990

Characterization of phorbol esters binding to K 562 cells

scientific article published on 01 January 1984

Characterization of the blast cell population in two neonates with Down's syndrome and transient myeloproliferative disorder

scientific article published on 01 May 1987

Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy.

scientific article published in August 1988

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

scientific article (publication date: September 2000)

Cloning, expression, and function of BLAME, a novel member of the CD2 family.

scientific article

Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms

scientific article

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

scientific article

Comparison of endothelial promoter efficiency and specificity in mice reveals a subset of Pdgfb-positive hematopoietic cells

scientific article published on 24 March 2019

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

scientific article

Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.

scientific article

Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis

scientific article published on 01 August 2007

Detection of cells of megakaryocyte lineage in haematological malignancies by immuno-alkaline phosphatase labelling cell smears with a panel of monoclonal antibodies

scientific article published on 01 January 1987

Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation

scientific article published on 29 November 2007

Early clinical trials with colony-stimulating factors.

scientific article published on January 1989

Early erythroid markers as probes for normal and leukaemic erythroid differentiation

scientific article published on 01 November 1987

Early expression of glycophorin C during normal and leukemic human erythroid differentiation

scientific article

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease.

scientific article

Effect of recombinant human granulocyte-macrophage colony stimulating factor on progenitor cells in patients with advanced malignancies

scientific article published on 01 January 1990

Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias

scientific article published on 01 October 1987

Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients

scientific article published on 01 December 1988

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.

scientific article published on August 2017

Erythroid properties of K562 cells. Effect of hemin, butyrate and TPA induction

scientific article published on 01 July 1983

Erythropoietin gene transfer and expression in adult normal mice: use of an adenovirus vector

scientific article published on August 1994

Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

scientific article

Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer.

scientific article published on January 1999

Expression of blood group A antigen during erythroid differentiation in A1 and A2 subjects

scientific article published on 01 January 1987

Expression of osteoprotegerin mRNA and protein in murine megakaryocytes

scientific article published on 01 November 2003

Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21

Fatal polycythemia induced in mice by dysregulated erythropoietin production by hematopoietic cells

scientific article published on 01 February 1992

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

scientific article published on 12 April 2018

Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2.

scientific article

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

scientific article

High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice

scientific article published on 01 December 1997

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta)

scientific article published on 01 January 1988

Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments

scientific article published on 01 December 2003

Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.

scientific article published on 4 October 2004

Immunophenotype of leukemic blasts with small peroxidase-positive granules detected by electron microscopy

scientific article published on 01 May 1988

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis

scientific article published on 22 May 2017

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice

scientific article

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

scientific article

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

scientific article published on 17 July 2013

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

scientific article

JAK2V⁶¹⁷F/TET2 mutations: does the order matter?

scientific article published on May 2011

Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity

scientific article published on 04 March 2009

Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia

scientific article published on 01 January 1989

Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression

scientific article

Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin

scientific article published on 01 June 2006

Mpl ligand (thrombopoietin) and platelet regulation

scientific article

Mpl ligand or thrombopoietin: biological activities.

scientific article published on January 1998

Mutations in JAK2V617F homologous domain of JAK genes are uncommon in solid tumors

article

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

scientific article published on 14 May 2010

New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients.

scientific article published on June 2006

Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation.

scientific article published on 9 September 2010

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.

scientific article published on 26 October 2006

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2.

scientific article

Phenotype of early erythroblastic leukemias

scientific article published on 01 November 1986

Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen

scientific article published on 31 August 2004

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

scientific article published on 20 March 2007

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

scientific article published on 19 October 2018

Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.

scientific article published in June 1998

Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.

scientific article

Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.

scientific article published on 9 July 2009

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

scientific article published on 7 November 2011

Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO.

scientific article

Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.

scientific article published in May 1997

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes

scientific article published on 29 February 2012

Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis

scientific article published on 13 October 2010

Ultrastructural and cytochemical characterization of blasts from early erythroblastic leukemias

scientific article published on 01 March 1987

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

scientific article

Vascular endothelial cell expression of JAK2 is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

scientific article published on 31 August 2018

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

scientific article published in August 2007

[Physiopathologic and therapeutic importance of animal models of hemoglobinopathies]

scientific article published on 01 June 1993

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

scientific article

Paulina is supported by:

About Paulina

Help