List of works - Ana E. Sousa

Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood.

scientific article published on 2 March 2018

Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy

scientific article

Bee venom enhances the differentiation of human regulatory T cells

scientific article

Bulk Cytokine Production versus Frequency of Cytokine-Producing Cells in HIV1 Infection before and during HAART

article

CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load

scientific article published in September 2002

CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

article

CD4⁺ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis.

scientific article published in June 2011

Cell-associated viral burden provides evidence of ongoing viral replication in aviremic HIV-2-infected patients

scientific article

Comparison of the frequency of interleukin (IL)-2-, interferon-gamma-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes.

scientific article published on 31 July 2001

Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies

scientific article published on 28 February 2019

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells

scientific article published on 3 November 2014

Dendritic cell differentiation and maturation in the presence of HIV type 2 envelope

scientific article published in April 2009

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

scientific article published on 01 September 2020

Differentiation of human thymic regulatory T cells at the double positive stage.

scientific article

Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery.

scientific article published on May 1999

Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection

scientific article

Enteric mucosa integrity in the presence of a preserved innate interleukin 22 compartment in HIV type 1-treated individuals

scientific article published on 5 March 2014

Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment

scientific article

EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid System

scientific article published on 13 June 2019

Expansion of FOXP3+ regulatory CD4 T cells upon exposure to hymenoptera venom during the beekeeping season

scientific article published on 17 January 2019

Expansion of circulating Foxp3+)D25bright CD4+ T cells during specific venom immunotherapy

scientific article published on 7 December 2007

First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases

scientific article

Follicular Helper T Cells Are Major Human Immunodeficiency Virus-2 Reservoirs and Support Productive Infection

scientific article published on 01 January 2020

Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression.

scientific article published on 9 February 2010

Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1.

scientific article published on 23 July 2008

Gut disruption in HIV-2 infection despite reduced viremia

scientific article published in January 2014

HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication

scientific article published on 17 May 2017

Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis

scientific article published in September 2000

Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation

scientific article

Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.

scientific article published in August 2017

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

scientific article

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus.

scientific article published on 4 December 2014

Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.

scientific article

IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner.

scientific article published on 13 November 2008

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

scientific article published on 19 January 2017

Increased frequency of CD25dimCD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1.

scientific article published on 3 March 2008

Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection

scientific article

Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV-1 infection.

scientific article published in March 1999

Long lasting myelodysplastic syndrome complicated by autoimmune hemolytic anemia and non-Hodgkin's lymphoma

scientific article published on 01 February 2002

Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation

scientific article

Low CD4 T-cell counts despite low levels of circulating HIV: Insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease

article

MDSCs in infectious diseases: regulation, roles, and readjustment

scientific article published on 19 December 2018

Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease

scientific article published on 11 May 2017

Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease

scientific article

Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity

article

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

scientific article published in April 2014

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia

scientific article published in August 2012

Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia.

scientific article published in October 2011

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

scientific article published on 01 September 2012

Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease

scientific article published on 4 March 2013

Monocyte-mediated T cell suppression by HIV-2 envelope proteins

article

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia.

scientific article published in June 2012

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

scientific article

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

scientific article published in January 2013

Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation

scientific article

Quantification of cell cycle kinetics by EdU (5-ethynyl-2'-deoxyuridine)-coupled-fluorescence-intensity analysis

scientific article

Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes

scientific article

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

scientific article published on April 2013

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

scientific article published on 09 May 2014

Regulatory T-Cell Development in the Human Thymus

scientific article (publication date: 2015)

Repairing thymic function

scientific article published on June 2013

Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: evidence for a major alteration within the CD8+ T cell subset.

scientific article published in May 1998

Strategies to quantify unspliced and multiply spliced mRNA expression in HIV-2 infection.

scientific article published on 22 April 2011

Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines

scientific article published on 2 October 2013

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

scientific article

Takayasu's disease presenting as a nephrotic syndrome due to amyloidosis.

scientific article published on June 1993

The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System

scientific article published on 04 March 2019

The selective cytotoxicity of new triazene compounds to human melanoma cells.

scientific article

Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.

scientific article

Thymic stromal alterations and genetic disorders of immune system

scientific article published on 25 February 2015

[The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations]

scientific article published on 01 October 1995

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.

scientific article published on 19 December 2016

List of works by Ana E. Sousa

Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood.

Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy

Bee venom enhances the differentiation of human regulatory T cells

Bulk Cytokine Production versus Frequency of Cytokine-Producing Cells in HIV1 Infection before and during HAART

CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load

CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

CD4⁺ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis.

Cell-associated viral burden provides evidence of ongoing viral replication in aviremic HIV-2-infected patients

Comparison of the frequency of interleukin (IL)-2-, interferon-gamma-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes.

Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells

Dendritic cell differentiation and maturation in the presence of HIV type 2 envelope

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

Differentiation of human thymic regulatory T cells at the double positive stage.

Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery.

Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection

Enteric mucosa integrity in the presence of a preserved innate interleukin 22 compartment in HIV type 1-treated individuals

Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment

EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid System

Expansion of FOXP3+ regulatory CD4 T cells upon exposure to hymenoptera venom during the beekeeping season

Expansion of circulating Foxp3+)D25bright CD4+ T cells during specific venom immunotherapy

First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases

Follicular Helper T Cells Are Major Human Immunodeficiency Virus-2 Reservoirs and Support Productive Infection

Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression.

Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1.

Gut disruption in HIV-2 infection despite reduced viremia

HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication

Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis

Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation

Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus.

Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.

IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner.

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Increased frequency of CD25dimCD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1.

Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection

Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV-1 infection.

Long lasting myelodysplastic syndrome complicated by autoimmune hemolytic anemia and non-Hodgkin's lymphoma

Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation

Low CD4 T-cell counts despite low levels of circulating HIV: Insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease

MDSCs in infectious diseases: regulation, roles, and readjustment

Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease

Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease

Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia

Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia.

Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels

Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease

Monocyte-mediated T cell suppression by HIV-2 envelope proteins

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia.

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation

Quantification of cell cycle kinetics by EdU (5-ethynyl-2'-deoxyuridine)-coupled-fluorescence-intensity analysis

Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Regulatory T-Cell Development in the Human Thymus

Repairing thymic function

Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: evidence for a major alteration within the CD8+ T cell subset.

Strategies to quantify unspliced and multiply spliced mRNA expression in HIV-2 infection.

Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Takayasu's disease presenting as a nephrotic syndrome due to amyloidosis.

The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System

The selective cytotoxicity of new triazene compounds to human melanoma cells.

Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.

Thymic stromal alterations and genetic disorders of immune system

[The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations]

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.