List of works - João T. Barata

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

scientific article published on 4 October 2011

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

scientific article

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

scientific article published on 8 August 2013

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia.

scientific article published on 6 November 2013

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

scientific article

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

scientific article published on 03 February 2022

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

scientific article

CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

scientific article

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress.

scientific article published on 18 August 2014

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.

scientific article

Checkmate to CHK1 in T-cell ALL?

scientific article

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

scientific article published on 20 November 2013

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein

scientific article published on 2 July 2007

FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.

scientific article published on 21 December 2015

Flip the coin: IL-7 and IL-7R in health and disease

scientific article published on 19 November 2019

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

scientific article

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells

scientific article

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

scientific article

IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias

scientific article published on 18 May 2011

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.

scientific article published on 26 February 2010

IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner.

scientific article published on 13 November 2008

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

scientific article published on 19 January 2017

IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.

scientific article published on 13 November 2003

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia ⬇️

scientific article published on October 16, 2012

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

scientific article published on 19 September 2018

IL-7Rα: Mr Hyde's twists and turns

scientific article published in December 2013

Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells

scientific article published on 10 March 2010

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

scientific article published on April 2013

Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling

scientific article published on 3 July 2008

Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?

scientific article

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

scientific article published in September 2001

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

scientific article published on 14 December 2021

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

scientific article

Kinases, tails and more: regulation of PTEN function by phosphorylation

scientific article

Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis

scientific article

Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype

scientific article published on 12 October 2015

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

scientific article

Molecular and functional evidence for activity of murine IL-7 on human lymphocytes

scientific article published on September 2006

Multifaceted CK2 in malignant and healthy T cells

scientific article published on 9 October 2017

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

scientific article published on 04 October 2019

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

scientific article published on 15 October 2009

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

scientific article published on 22 August 2019

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

scientific article published in March 2013

On CK2 regulation of chronic lymphocytic leukemia cell viability

scientific article

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

scientific article

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

scientific article

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

scientific article published on 01 September 2021

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

scientific article published on 30 June 2020

PTEN and leukemia stem cells

scientific article published on 14 June 2014

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

scientific article published on 05 June 2014

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

scientific article published on October 2008

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

scientific article

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

scientific article published on 09 May 2014

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors

scientific article

STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.

scientific article

T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7

scientific article published on 15 August 2019

TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

scientific article published on 07 June 2011

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

scientific article

Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors

scientific article published on 26 January 2011

The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

scientific article published in December 2015

The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity

scientific article

The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival ⬇️

scientific article published on October 28, 2010

The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

scientific article

Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises

scientific article published on September 2011

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.

scientific article

Therapeutic targeting of CK2 in acute and chronic leukemias.

scientific article

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

scientific article published on 23 January 2016

List of works by João T. Barata

A unified nomenclature and amino acid numbering for human PTEN.

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia.

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress.

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.

Checkmate to CHK1 in T-cell ALL?

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein

FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.

Flip the coin: IL-7 and IL-7R in health and disease

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.

IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner.

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia ⬇️

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

IL-7Rα: Mr Hyde's twists and turns

Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling

Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

Kinases, tails and more: regulation of PTEN function by phosphorylation

Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis

Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

Molecular and functional evidence for activity of murine IL-7 on human lymphocytes

Multifaceted CK2 in malignant and healthy T cells

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

On CK2 regulation of chronic lymphocytic leukemia cell viability

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

PTEN and leukemia stem cells

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors

STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.

T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7

TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors

The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity

The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival ⬇️

The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.

Therapeutic targeting of CK2 in acute and chronic leukemias.

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia