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List of works by Manolis Pasparakis

A Way to DAI ⬇️

scientific article published on March 15, 2012

A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.

scientific article

A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling

scientific article published on 01 October 1997

A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects.

scientific article published on 29 December 2015

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

scientific article published on 14 August 2011

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

scientific article

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

scientific article published on 13 May 2019

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

scientific article published on 18 September 2019

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

scientific article published on 25 September 2018

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

scientific article

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

scientific article published on 08 April 2020

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice

scientific article published on 05 April 2016

BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells

scholarly article

Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo

scientific article published on 13 February 2013

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

scientific article

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

scientific article published on 10 May 2012

CCR2+ monocytic-Myeloid Derived Immunosuppressive Cells (M-MDSC) inhibit collagen degradation and promote lung fibrosis by producing TGF-β1.

scientific article published on 11 August 2017

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

scientific article published on 20 November 2019

Cigarette smoke induced airway inflammation is independent of NF-κB signalling

scientific article

Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function ⬇️

scientific article published on August 17, 1998

Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance

scientific article (publication date: February 2004)

Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis

scientific article published on 30 August 2012

Connecting immune deficiency and inflammation

scientific article published on 01 August 2018

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

scientific article

Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

scientific article published on 23 January 2020

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

scientific article published in Nature Communications

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

scientific article

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.

scientific article

Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation

scientific article published on 19 June 2008

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

scientific article published on 17 March 2005

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

scientific article published on 01 February 2007

Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity

scientific article

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals

scientific article published on 03 May 2009

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

scholarly article

Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes

scientific article published on 9 March 2018

Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.

scientific article

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.

scientific article published on April 1996

Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis.

scientific article published in July 2006

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

scientific article

Endothelial and macrophage-specific deficiency of P38α MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice

scientific article

Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis

scientific article

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

scientific article

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

scientific article

Epithelial Cell Death and Inflammation in Skin

scientific article published on 15 August 2015

Epithelial IKKα licenses ILC3s to defend the intestinal barrier

scientific article

Epithelial NEMO links innate immunity to chronic intestinal inflammation

scientific article published in Nature

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

scientific article published on 31 July 2011

FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses

scientific article published in January 2006

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

article

GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo

scientific article published in May 2009

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

scientific article published on 30 October 2021

Generalized immune activation as a direct result of activated CD4+ T cell killing

scientific article

Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits

scientific article

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

scientific article

Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway

scientific article

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

scholarly article

Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure

scientific article

I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion

scientific article published in August 2004

IKK mediates ischemia-induced neuronal death

scientific article

IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut.

scientific article

IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

scholarly article

IKK2 inhibition attenuates laser-induced choroidal neovascularization

scientific article (publication date: 2014)

IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells

scientific article published on 3 August 2006

IKKβ deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology

scientific article published in September 2014

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

scientific article

IRF5:RelA interaction targets inflammatory genes in macrophages

scientific article published on 21 August 2014

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

scientific article published in April 2008

IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system

scientific article

IkappaB kinase signaling is essential for maintenance of mature B cells

scientific journal article

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

scientific journal article

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

scientific article published on 01 March 1999

Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.

scientific article

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

article

Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.

scientific article

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

scholarly article by Geert van Loo et al published 6 August 2006 in Nature Immunology

Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity

scientific article published in October 2009

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

scientific article published on 01 January 2019

Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria

scientific article published on 12 September 2012

IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma

scientific article published on 27 March 2018

K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells

scientific article published on August 2013

Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein

scientific article

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

scientific article published on 13 May 2011

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.

scientific article published on May 2017

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

scientific article published on 19 June 2017

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

scientific article published in Nature Communications

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

scientific article published on 06 November 2019

Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response

scientific article

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis

scientific article published in March 2006

M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

scientific journal article

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

scientific article

Mature T cells depend on signaling through the IKK complex

scientific article published in September 2003

Mechanisms regulating skin immunity and inflammation

scientific article published on 11 April 2014

Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

article

Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis

scientific article published in July 1999

Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

scientific article published on 21 July 2020

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

scientific article published on 11 December 2019

Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression

scientific article published on 01 May 1999

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

scientific article published on March 2016

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

scientific journal article

NEMO/IKK gamma-deficient mice model incontinentia pigmenti

scientific article published in June 2000

NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function.

scientific article published on 19 January 2016

NF-κB in the regulation of epithelial homeostasis and inflammation ⬇️

scientific article published on December 14, 2010

NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma

scientific article published on 5 September 2015

Necroptosis and its role in inflammation

scientific article

Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs

scientific article

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation

scientific article published on 11 March 2007

OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

scientific article published on 08 October 2021

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.

scientific article published on September 1998

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination

scientific article published on 10 November 2010

Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice

scientific article

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

scientific article

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation

scientific article published on August 2006

Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

scientific article

Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth

scientific article

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

scientific article published on 01 July 1997

Prion propagation in mice lacking central nervous system NF- B signalling

Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

scientific article published on 01 April 2020

RIP Kinases in Liver Cell Death, Inflammation and Cancer

scientific article published on 16 November 2018

RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome

scientific article published on 16 April 2018

RIP kinase 3 in necroptosis: does it take two or more to kill?

scientific article published on October 2014

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

scientific article published on 10 October 2019

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

scientific article published on 28 December 2018

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

scientific article published on 15 April 2019

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

scientific article

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

scientific article

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

scientific article

Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent

scientific article published on 4 November 2011

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

scientific article published on 05 November 2021

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases

scientific article

Role of NF-κB in epithelial biology

scientific article published on March 2012

Role of TNF in pathologies induced by nuclear factor kappaB deficiency

scientific article published on 18 February 2010

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

scientific article

Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis

scientific article published on 27 September 2013

Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke

scientific article published on 18 February 2020

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

scientific article

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling

scientific article published on 6 January 2006

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

scientific article

Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles

scientific article (publication date: 2009)

Synchronized renal tubular cell death involves ferroptosis. ⬇️

scientific article

TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

scholarly article by George Kassiotis et al published March 1999 in European Journal of Immunology

TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

scientific article published on 01 March 1999

TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation

article by Dirk Wohlleber et al published September 2012 in Cell Reports

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration

scientific article published on February 1997

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

scientific article published in Nature

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

scientific article

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice

scientific article published in September 1997

Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment

scientific article published on 23 July 2019

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

scientific article published on 13 October 2011

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression

article

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells

scientific article

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

scientific article

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

scientific article published on 12 February 2018

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

scientific article published on 04 September 2018

The tumour suppressor CYLD regulates the p53 DNA damage response

scientific article

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

scientific article

Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency

scientific article published on 23 January 2016

Tumor Necrosis Factor and the p55TNF Receptor Are Required for Optimal Development of the Marginal Sinus and for Migration of Follicular Dendritic Cell Precursors into Splenic Follicles

scientific article published on 01 April 2000

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

scientific article published on August 2004

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

scientific journal article

Tumour necrosis factors in immune regulation: everything that's interesting is...new!

scientific article published on October 1996

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

scientific article published on 3 August 2016

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

scientific article

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

scientific article published on 25 March 2020

p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure

scientific article published on 15 August 2008

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

scientific article published on 29 April 2007

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