List of works - Hirohito Sone

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces binding of a 50 kDa protein on the 3' untranslated region of urokinase-type plasminogen activator mRNA.

scientific article published in June 2000

5. Cardiovascular Diseases

scientific article published on 01 April 2009

A 52-week randomized controlled trial of ipragliflozin or sitagliptin in type 2 diabetes combined with metformin: The N-ISM study

scientific article published on 08 January 2021

A Case of Shy-Drager Syndrome Complicated with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) and Incomplete Paralysis of Bilateral Vocal Cords

scientific article published on 01 March 1994

A New Synthetic Steroid, Osaterone Acetate (TZP-4238), Increases Cortical Bone Mass and Strength by Enhancing Bone Formation in Ovariectomized Rats

scientific article published on 01 April 1997

A Prospective Cohort Study Of Physical Fitness And Incident Hearing Loss: The Niigata Wellness Study

scientific article published in 2020

A Prospective Cohort Study of Muscular and Performance Fitness and Incident Glaucoma: The Niigata Wellness Study

scientific article published on 13 October 2020

A Prospective Cohort Study of Muscular and Performance Fitness and Risk of Hearing Loss: The Niigata Wellness Study

scientific article published on 17 July 2020

A possible link between BDNF and mTOR in control of food intake

scientific article

A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).

scientific article

A study on the neotetrazolium reductase system in the kidney cells of chick embryo by microspectrophotometry. II. Determination of the activity of the NADP-dependent dehydrogenase system

scientific article published in November 1970

A study on the quantitative determination of intracellular formazan by microspectrophotometry

scientific article published on 01 November 1970

ACUTE TOXICITY TESTS OF MOFEZOLAC (N-22) IN MICE AND RATS

scientific article published on 01 June 1990

AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats

scientific article published on 30 May 2011

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

scientific article published on 02 June 2014

Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency

scientific journal article

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

scientific article

Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.

scientific article published in January 2010

Accumulation of cardiovascular risks in Japanese women with abnormal glucose and mild to moderate hypercholesterolemia

scientific article published on 8 September 2011

Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice

scientific article published in October 2004

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

scientific journal article

Action of nicotine on guinea-pig isolated bronchial smooth muscle preparation.

scientific article

Activation of telomerase in BeWo cells by estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin in co-operation with c-Myc.

scientific article published in January 2006

Activation of the leukemia plasmacytoid dendritic cell line PMDC05 by Toho-1, a novel IDO inhibitor

scientific article

Acute Effects of Thromboxane Dual Blocker (KDI-792) on Different Portions of Lower Limb Blood Flow—A Study Using Doppler Ultrasonography and Laser Doppler Flowmetry in Type 2 Diabetic Patients ⬇️

scientific article published on June 1, 1997

Acute effect of beraprost sodium on lower limb circulation in patients with non-insulin-dependent diabetes mellitus-evaluation by color Doppler ultrasonography and laser cutaneous blood flowmetry.

scientific article published on November 1996

Acute gliclazide administration enhances glucose and ketone body utilization in the perfused hind limb of normal and streptozotocin-diabetic rats

scientific article

Administration of biotin prevents the development of insulin resistance in the skeletal muscles of Otsuka Long-Evans Tokushima fatty rats

article

Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation.

scientific article published on 08 February 2017

Affinity-based elimination of aromatic VOCs by highly crystalline multi-walled carbon nanotubes

scientific article published on 7 September 2007

Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients

scientific article

Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles.

scientific article

Alcohol consumption and risk of atrial fibrillation: a meta-analysis

scientific article

Alcohol use and diabetes mellitus

scientific article published in September 2004

Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats.

scientific article published on October 2006

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity.

scientific article published on 31 July 2013

Analysis of the TNF receptor on KYM cells by binding assay and affinity cross-linking

scientific article published in June 1988

Anti-tumor effect and mechanism of action of the tumor necrosis factor (TNF)

scientific article

Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy

scientific article published in January 2006

Antitumor effect of the tumor necrosis factor against various types of human cancer cells

scientific article

Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells

scientific article published on 01 November 1985

Antitumor synergism between recombinant human tumor necrosis factor and recombinant human interferon-r

scientific article published on 01 February 1988

Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity

scientific article published on April 1990

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength

scientific article published on 01 September 2020

Are serum cholesterol levels associated with silent brain infarcts? The Seiryo Clinic Study

scientific article published on 22 January 2010

Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21

scientific article published on 01 February 2016

Association between Helicobacter pylori infection, eradication and diabetes mellitus

scientific article published on 12 February 2019

Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes

scientific article published on 01 June 2020

Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS).

scientific article published on 31 May 2017

Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis.

scientific article published on February 2013

Association between remission of macroalbuminuria and preservation of renal function in patients with type 2 diabetes with overt proteinuria.

scientific article published on 18 June 2013

Association between serum uric acid and development of type 2 diabetes.

scientific article published on 23 June 2009

Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis

scientific article

Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up

scientific article published on 25 April 2016

Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin

scientific article published on 27 January 2020

Association of living alone with the presence of undiagnosed diabetes in Japanese men: the role of modifiable risk factors for diabetes: Toranomon Hospital Health Management Center Study 13 (TOPICS 13).

scientific article published on 9 July 2013

Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes

scientific article published in 2022

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias ⬇️

scientific article published on May 31, 2012

Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages

scientific article published on 26 September 2009

Attenuation of weight loss through improved antilipolytic effect in adipose tissue via the SGLT2 inhibitor tofogliflozin

scientific article published on 01 September 2019

Aurisides A and B, Cytotoxic Macrolide Glycosides from the Japanese Sea Hare Dolabella auricularia

scientific article published on 01 December 1996

BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens

scientific article published on January 2004

Background to discuss guidelines for control of plasma HDL-cholesterol in Japan

scientific article published on 12 January 2012

Biotin Administration Improves the Impaired Glucose Tolerance of Streptozotocin-Induced Diabetic Wistar Rats ⬇️

scientific article published on 01 June 1997

Biotin augments acetyl CoA carboxylase 2 gene expression in the hypothalamus, leading to the suppression of food intake in mice

scientific article

Biotin enhances ATP synthesis in pancreatic islets of the rat, resulting in reinforcement of glucose-induced insulin secretion

scientific article published in February 2004

Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat.

scientific article

Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance

scientific journal article

Body Flexibility and Incident Hypertension: The Niigata Wellness Study

scientific article published on 03 November 2020

Body mass index and mortality among Japanese patients with type 2 diabetes: pooled analysis of the Japan diabetes complications study and the Japanese elderly diabetes intervention trial

scientific article

Body weight change and type 2 diabetes.

scientific article published in September 2013

Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase.

scientific article published on 28 February 2014

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.

scientific article published on 16 December 2016

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

scientific article published on 21 February 2020

Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women.

scientific article published on 20 March 2017

Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis

scientific article

Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus

scientific article published in March 2018

Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus.

scientific article

Cell cycle specificity of tumor necrosis factor and its receptor

scientific article published in November 1987

Cerebral hemorrhagic infarction after radiation for pituitary adenoma.

scientific article published in October 2002

Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin

scientific article published in December 2001

Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats ⬇️

scientific article published on January 1, 2002

Characteristics of the Biotin Enhancement of Glucose-induced Insulin Release in Pancreatic Islets of the Rat

scientific article published on 01 March 2000

Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα.

scientific article published on 12 October 2012

Chronic kidney disease categories and renal-cardiovascular outcomes in type 2 diabetes without prevalent cardiovascular disease: a prospective cohort study (JDDM25).

scientific article

Cigarette Smoking Is Associated With Low Glomerular Filtration Rate in Male Patients With Type 2 Diabetes: Response to De Cosmo et al

scientific article published on 01 March 2007

Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes

scientific article

Clinical and pathophysiological features of Japanese patients with type 2 diabetes mellitus and their risk factors for diabetic complication

scientific article

Clinicopathological features of cryptococcal lymphadenitis and a review of literature.

scientific article published on 8 June 2017

Clinicopathological, Cytogenetic, and Prognostic Analysis of 131 Myeloid Sarcoma Patients

scientific article published on 14 September 2016

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

scientific article

Cloning and sequence analysis of the arginine deiminase gene from Mycoplasma arginini.

scientific article

Cluster-randomized trial to improve the quality of diabetes management: The study for the efficacy assessment of the standard diabetes manual (SEAS-DM).

scientific article published on 12 December 2015

Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat.

scientific article published on 17 May 2013

Cohort profile: The Japan diabetes complications study: a long-term follow-up of a randomised lifestyle intervention study of type 2 diabetes.

scientific article

Combination effect of hypertension and diabetes mellitus on urinary protein excretion

Combination of diabetes mellitus and lack of habitual physical activity is a risk factor for functional disability in Japanese

scientific article published on 01 January 2020

Combined Effects of Energy Intake and Physical Activity on Obesity in Japanese Patients with Type 2 Diabetes (JDDM 50): A Cross-Sectional Study

scientific article published on 03 April 2019

Commentary on the United Kingdom Prospective Diabetes Study outcomes model 2: Need for long-term follow up and quality of life data in Asian patients

scientific article

Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.

scientific article published on 9 December 2009

Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on MCF-7, RL95-2, and LNCaP cells: role of target steroid hormones in cellular responsiveness to CYP1A1 induction.

scientific article

Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy

scientific article published on 24 September 2016

Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42).

scientific article published on February 2017

Comparison of clinical characteristics in patients with type 2 diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists.

scientific article published on 26 July 2015

Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified

scientific article

Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12).

scientific article published on 14 May 2014

Comparison of education-only versus group-based intervention in promoting weight loss: a randomised controlled trial.

scientific article published on 9 June 2011

Comparison of lipid parameters to predict cardiovascular events in Japanese mild-to-moderate hypercholesterolemic patients with and without type 2 diabetes: Subanalysis of the MEGA study

scientific article

Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery ste

scientific article published on 8 April 2014

Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: a meta-analysis.

scientific article published on 9 November 2012

Components of metabolic syndrome and their combinations as predictors of cardiovascular disease in Japanese patients with type 2 diabetes. Implications for improved definition. Analysis from Japan Diabetes Complications Study (JDCS).

scientific article

Continuous internalization of TNF receptors in a human myosarcoma cell line

scientific article published on February 1988

Continuous internalization of tumor necrosis factor receptors in a human myosarcoma cell line.

scientific article published on July 1988

Contribution of first trimester fasting plasma insulin levels to the incidence of glucose intolerance in later pregnancy: Tanaka women's clinic study

scientific article published on 10 March 2011

Contribution of glimepiride to basal–prandial insulin therapy in patients with type 2 diabetes

scientific article published on 09 November 2010

Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma

scientific article published on 01 March 1996

Correlation between SNP genotypes and periodontitis in Japanese type II diabetic patients: a preliminary study

scientific article published on 14 August 2014

Cross-sectional association between BMI, glycemic control and energy intake in Japanese patients with type 2 diabetes

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

scientific article published in May 2003

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

scientific article published on May 2003

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

scientific article published on 30 September 2007

Cutting-edge of medicine; clinical epidemiology regarding clinical and pathophysiological features of Japanese patients with type 2 diabetes mellitus

scientific article published in October 2013

Cytocidal mechanism of TNF: effects of lysosomal enzyme and hydroxyl radical inhibitors on cytotoxicity

scientific article published on January 1988

Cytologic characteristics of oat-cell carcinoma of the lung in relation to the effect of chemotherapy ⬇️

scientific article published on 01 January 1981

DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats

scientific article published in October 2002

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.

scientific article published on 20 August 2015

DNA-adduct formation in lungs, nasal mucosa, and livers of rats exposed to urban roadside air in Kawasaki City, Japan.

scientific article published on September 2003

Determinants of decline in glomerular filtration rate in nonproteinuric subjects with or without diabetes and hypertension

scientific article published on September 2009

Development and evaluation of the Japanese version of the Audit of Diabetes-Dependent Quality of Life for patients with diabetes.

scientific article published on 10 March 2016

Development of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6).

scientific article published on 7 September 2012

Development of a robust method for establishing B cell lines using Epstein-Barr Virus ⬇️

scientific article published on July 18, 2012

Development of a screening score for undiagnosed diabetes and its application in estimating absolute risk of future type 2 diabetes in Japan: Toranomon Hospital Health Management Center Study 10 (TOPICS 10).

scientific article published on 7 February 2013

Diabetes Care in Emergency Settings

scientific article published on 01 September 1995

Diabetes and risk of hearing impairment in adults: a meta-analysis.

scientific article

Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis

scientific article published on 29 July 2020

Diabetic retinopathy and microalbuminuria can predict macroalbuminuria and renal function decline in Japanese type 2 diabetic patients: Japan Diabetes Complications Study

scientific article published on 25 April 2013

Diagnosis and Management of Type I and Type V Hyperlipoproteinemia

scientific article published on 01 December 2011

Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study

scientific article

Dietary salt intake and diabetes complications in patients with diabetes: An overview.

scientific article

Dietary sodium intake and incidence of diabetes complications in Japanese patients with type 2 diabetes: analysis of the Japan Diabetes Complications Study (JDCS).

scientific article published on 22 July 2014

Differences in occupational stress by smoking intensity and gender in cross-sectional study of 59 355 Japanese employees using the Brief Job Stress Questionnaire (BJSQ): the Niigata Wellness Study

scientific article published in 2022

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

scientific article

Direct effect of dasatinib on proliferation and cytotoxicity of natural killer cells in in vitro study

scientific article published on 29 October 2012

Disease model: hyperinsulinemia and insulin resistance. Part B--polygenic and other animal models.

scientific article

Distribution of retinylester-storing stellate cells in the arrowtooth halibut, Atheresthes evermanni

scientific article published on 30 June 2006

Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis

scientific article

Dose of 3‐methylcholanthrene enhances vitamin C accumulation and mRNA expression of its transporter in the liver of ODS rats and in HepG2 cells ⬇️

scientific article published on July 28, 2011

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha

scientific article published in January 2002

Early diagnosis of hepatic intravascular lymphoma: a case report and literature review.

scientific article published on January 2014

Effect of Endurance Exercise Training on Oxidative Stress in Spontaneously Hypertensive Rats (SHR) After Emergence of Hypertension ⬇️

scientific article published on September 9, 2010

Effect of family-oriented diabetes programs on glycemic control: A meta-analysis

scientific article published on 01 July 2019

Effect of low-dose thalidomide on dopaminergic neuronal differentiation of human neural progenitor cells: a combined study of metabolomics and morphological analysis.

scientific article

Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17).

scientific article published on 29 October 2013

Effect of smoking on diabetes mellitus and dyslipidemia (effect of smoking on glucose and lipid metabolism)

scientific article

Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats

scientific article

Effect of weight reduction on concentration of plasma total homocysteine in obese Japanese men.

scientific article published in October 2007

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57Bl/6 mice

scientific article published in March 2002

Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells.

scientific article published on 22 January 2016

Effects of PAMAM dendrimers in the mouse brain after a single intranasal instillation

scientific article published on 9 May 2014

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

scientific article published in January 2016

Effects of Polyamidoamine Dendrimers on a 3-D Neurosphere System Using Human Neural Progenitor Cells

scientific article published on 28 April 2016

Effects of acute single intranasal instillation of secondary organic aerosol on neurological and immunological biomarkers in the brain and lung of BALB/c mice

scientific article published on February 2013

Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells.

scientific article published on March 2012

Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet.

scientific article

Effects of gomisin J and analogous lignan compounds in schisandra fruits on isolated smooth muscles

scientific article published on September 1987

Effects of high glucose concentration and a thromboxane synthase inhibitor on the production of thromboxane A2 and prostaglandin I2 and E2 by cultured retinal endothelial cells

scientific article published on 01 January 1996

Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy

article

Effects of lifestyle modifications on patients with type 2 diabetes: the Japan Diabetes Complications Study (JDCS) study design, baseline analysis and three year-interim report

scientific article published in September 2002

Effects of magnesium on postprandial serum lipid responses in healthy human subjects.

scientific article published on 27 November 2009

Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells

scientific article published on April 23, 2012

Effects of the novel orally active antiestrogen TZE-5323 on experimental endometriosis

scientific article published in January 2003

Efficacy and safety in sitagliptin therapy for diabetes complicated by non-alcoholic fatty liver disease.

scientific article published on 12 March 2013

Efficacy and safety of empagliflozin as add-on to insulin in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial

scientific article published on 20 December 2019

Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals.

scientific article published on 5 November 2014

Efficacy of Ibudilast on lower limb circulation of diabetic patients with minimally impaired baseline flow: a study using color Doppler ultrasonography and laser Doppler flowmetry.

scientific article published on August 1995

Efficacy of habitual exercise for improving lipid profiles depends on the PPRAγ genotype in Japanese males

scientific article published in January 2014

Efficient establishment of primary fibroblast cultures from the hawksbill sea turtle (Eretmochelys imbricata).

scientific article

Eicosapentaenoic acid suppresses basal and insulin-stimulated endothelin-1 production in human endothelial cells

scientific article published on August 2003

Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis Correlation with disease activity

scientific article published on 01 September 2001

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.

scientific article

Elovl6 promotes nonalcoholic steatohepatitis

scientific article published on 01 December 2012

Energy intake and obesity in Japanese patients with type 2 diabetes

scientific article published in January 2004

Enhanced stability of YEp plasmids in lager brewing yeasts is related to lager brewing yeast 2-microns DNA

scientific article published on 01 November 1992

Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene

scientific article

Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells

scientific article published on 01 June 2000

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

scientific article published on 24 November 2020

Establishment of a reporter system to monitor silencing status in induced pluripotent stem cell lines.

scientific article published on 21 August 2013

Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans rats

scientific article published on 01 January 2000

Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems

scientific article published on 27 April 2007

Evaluation of x-ray patterns of bronchograms in pulmonary cancer

scientific article published on 01 September 1971

Even Low-Intensity and Low-Volume Exercise Training May Improve Insulin Resistance in the Elderly

scientific article published on 17 July 2007

Exogenous and endogenous ghrelin counteracts GLP‐1 action to stimulate cAMP signaling and insulin secretion in islet β‐cells ⬇️

scientific article published on June 29, 2012

Experimental study on Gamma Coat Renin and the plasma renin level determined by the renin RIA kit

scientific article published on 01 April 1983

Factors associated with inappropriate weight loss attempts by early adolescent girls in Japan.

scientific article published on September 2011

Familial predisposition to cardiovascular risk and disease contributes to cardiovascular risk and disease interacting with other cardiovascular risk factors in diabetes: implication for common soil (JDDM 14).

scientific article published on 6 March 2008

Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese with Type 2 Diabetes (JDDM 56)

scientific article published on 31 August 2020

Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysis.

scientific article published on 11 January 2012

Fasting glucose and HbA1c levels as risk factors for the development of hypertension in Japanese individuals: Toranomon hospital health management center study 16 (TOPICS 16).

scientific article published on 18 September 2014

Fasting insulin levels and metabolic risk factors in type 2 diabetic patients at the first visit in Japan: a 10-year, nationwide, observational study (JDDM 28)

scientific article

Fasting mediated increase in p-BAD(ser155) and p-AKT(ser473) in the prefrontal cortex of mice

scientific article published on 17 July 2014

Fatal tracheal aspergillosis during rituximab combined chemotherapy for diffuse large B-cell lymphoma that developed after lung transplantation.

scientific article published on 15 September 2015

Features of Japanese diabetic macroangiopathy

scientific article published on April 2016

Fibromyalgia in a Patient with Cushing's Disease Accompanied by Central Hypothyroidism.

scientific article

Fine needle aspiration cytology of malignant schwannoma metastatic to the breast

scientific article published in May 1989

Fine-needle aspiration cytology of malignant lymphoma of the thyroid

scientific article published on 01 September 1987

Flow-Mediated Dilation is Associated with Microalbuminuria Independent of Cardiovascular Risk Factors in Type 2 Diabetes

scientific article published on 20 May 2011

Food groups and weight gain in Japanese men.

scientific article published on 11 April 2014

Formation of dot arrays with a pitch of 20 nm × 20 nm for patterned media using 30 keV EB drawing on thin calixarene resist ⬇️

scientific article published on December 6, 2007

Fruit intake and incident diabetic retinopathy with type 2 diabetes

scientific article published in March 2013

Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review

scientific article

Gene interaction network analysis suggests differences between high and low doses of acetaminophen

scientific article published on 15 May 2006

Genetic and physiological analysis of branched-chain alcohols and isoamyl acetate production in Saccharomyces cerevisiae

scientific article published on 22 June 2002

Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats

scientific article published on January 1, 1992

Genetic variants of the fatty acid desaturase gene cluster are associated with plasma LDL cholesterol levels in Japanese males

scientific article published in January 2013

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells.

scientific article

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

scientific article published on 7 December 2007

Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential.

scientific article published on February 2008

Ghrelin signalling in β-cells regulates insulin secretion and blood glucose

scientific article published on September 2014

Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes

scientific journal article

Glutamic Acid Decarboxylase Autoantibody-negative Slowly Progressive Type 1 Diabetes Mellitus: A Case Report and Literature Review

scientific article published on 10 August 2018

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

scientific journal article

HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes

scientific article published in October 2002

HbA1c 5·7-6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study

scientific article published on 24 June 2011

HbA1c variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2

article

Hemiacetal Dehydrogenation Activity of Alcohol Dehydrogenases in Saccharomyces cerevisiae

scientific article published on 01 October 1998

Hemodynamic effects of lipo-PGE1 on peripheral artery in patients with diabetic neuropathy: evaluated by two-dimensional color Doppler echography

scientific article published on 01 January 1993

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

scientific article published on 18 September 2014

Hepatocellular carcinoma induction in LEC rats by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

scientific article

High cholesterol intake is associated with elevated risk of type 2 diabetes mellitus - a meta-analysis.

scientific article published on 13 March 2014

High normal HbA(1c) levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8).

scientific article published in October 2012

High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis

article

High-level expression of a sweet protein, monellin, in the food yeast Candida utilis

scientific article

Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes

scientific article published on 16 January 2019

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

scientific article published on 13 June 2016

Hypertension increases urinary excretion of immunoglobulin G, ceruloplasmin and transferrin in normoalbuminuric patients with type 2 diabetes mellitus

article

Hypoxia and endothelin-1 induce VEGF production in human vascular smooth muscle cells

article

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Type 2 Diabetes Prevalence in Asian Subjects: Response to McNeely and Boyko

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Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis.

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Use of high-normal levels of haemoglobin A(1C) and fasting plasma glucose for diabetes screening and for prediction: a meta-analysis

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Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals.

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Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis

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Utility of the triglyceride level for predicting incident diabetes mellitus according to the fasting status and body mass index category: the Ibaraki Prefectural Health Study.

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Vascular Endothelial Growth Factor Level in Aqueous Humor of Diabetic Patients With Rubeotic Glaucoma Is Markedly Elevated

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Vascular endothelial growth factor gene expression in a retinal pigmented cell is up-regulated by glucose deprivation through 3' UTR.

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Vascular endothelial growth factor in angiosarcoma

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Vascular endothelial growth factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells

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Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS)

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WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.

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Waist circumference as a cardiovascular and metabolic risk in Japanese patients with type 2 diabetes

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Weight and cardiometabolic risk among adolescents in Agano city, Japan: NICE EVIDENCE Study-Agano 1

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Weight loss maintenance for 2 years after a 6-month randomised controlled trial comparing education-only and group-based support in Japanese adults

scientific article published on 26 November 2014

Whole-body Autoradiographic Study of Vitamin K Distribution in Rat ⬇️

scientific article published on January 1, 1973

Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.

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Zeste tunes the timing of ecdysone actions in triggering programmed tissue degeneration in Drosophila.

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[A case of hypopituitarism complicated with the factor IX deficiency]

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[A case report of pregnancy associated with Crohn's disease maintained on enteral hyperalimentation]

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[An autopsy case of squamous cell carcinoma arising from the pancreas]

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[Analysis of the TNF receptor in KYM cells by affinity cross-linking]

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[Analysis of the signalling pathway of TNF in normal cells and tumor cells]

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[Anti-tumor effect of human recombinant TNF]

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[Characteristics of diabetic macroangiopathy in Japan and East Asia]

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[Clinical efficacy of arbekacin in patients with methicillin-resistant Staphylococcus aureus infections. Research Group of MRSA Forum]

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[Diabetes mellitus and metabolic syndrome in epidemiological studies]

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[Epidemiology of diabetic microangiopathy in Japan--comparison with Western countries]

scientific article published on 01 November 2010

[Factors affecting the development of urination disorders following total or subtotal hysterectomy and the management of the problem]

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[Fifty two-week chronic oral toxicity study of mofezolac (N-22) in rats]

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[Improved SPAC Cortisol II]

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[Induction of tumor necrosis factor (TNF) by OK-432]

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[Intervention study for elevating high density lipoprotein cholesterol level]

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[Japan Diabetes Complications Study (JDCS)]

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[Japan Diabetes Complications Study (JDCS)]

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[Large-scale randomized intervention trial on diabetes in Japan]

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[Long-term intervention studies of diabetic macroangiopathy in Japan and western countries]

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[Metabolic syndrome in Japanese patient with diabetes analysis from JDCS]

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[New vision of secondary and tertiary prevention in diabetic complication]

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[Prevalence and incidence of diabetic microangiopathy in Japan]

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[Recent studies on hyperlipidemia]

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[Recent trends in diabetic complications in Japan]

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[Stroke in the elderly people with diabetes mellitus].

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[Studies on analgesic drugs. XIV. Absorption, excretion, distribution and metabolism of 1-n-butyry-4-cinnamyl1[gamma-14C]piperazine hydrochloride (BCP-14C) in the rat (author's transl)]]

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[Successful treatment with bortezomib in a patient with systemic primary AL amyloidosis manifesting severe gastrointestinal bleeding]

[Synergistic effects of human recombinant TNF and hyperthermia on in vitro cytotoxicity and artificial metastases]

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[Vascular dysfunction in metabolic syndrome: 2) Risk for coronary artery disease]

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[Vascular endothelial growth factor levels in the aqueous and serum in diabetic retinopathy with or without neovascular glaucoma]

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p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus

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siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells.

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List of works by Hirohito Sone

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces binding of a 50 kDa protein on the 3' untranslated region of urokinase-type plasminogen activator mRNA.

5. Cardiovascular Diseases

A 52-week randomized controlled trial of ipragliflozin or sitagliptin in type 2 diabetes combined with metformin: The N-ISM study

A Case of Shy-Drager Syndrome Complicated with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) and Incomplete Paralysis of Bilateral Vocal Cords

A New Synthetic Steroid, Osaterone Acetate (TZP-4238), Increases Cortical Bone Mass and Strength by Enhancing Bone Formation in Ovariectomized Rats

A Prospective Cohort Study Of Physical Fitness And Incident Hearing Loss: The Niigata Wellness Study

A Prospective Cohort Study of Muscular and Performance Fitness and Incident Glaucoma: The Niigata Wellness Study

A Prospective Cohort Study of Muscular and Performance Fitness and Risk of Hearing Loss: The Niigata Wellness Study

A possible link between BDNF and mTOR in control of food intake

A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).

A study on the neotetrazolium reductase system in the kidney cells of chick embryo by microspectrophotometry. II. Determination of the activity of the NADP-dependent dehydrogenase system

A study on the quantitative determination of intracellular formazan by microspectrophotometry

ACUTE TOXICITY TESTS OF MOFEZOLAC (N-22) IN MICE AND RATS

AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.

Accumulation of cardiovascular risks in Japanese women with abnormal glucose and mild to moderate hypercholesterolemia

Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

Action of nicotine on guinea-pig isolated bronchial smooth muscle preparation.

Activation of telomerase in BeWo cells by estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin in co-operation with c-Myc.

Activation of the leukemia plasmacytoid dendritic cell line PMDC05 by Toho-1, a novel IDO inhibitor

Acute Effects of Thromboxane Dual Blocker (KDI-792) on Different Portions of Lower Limb Blood Flow—A Study Using Doppler Ultrasonography and Laser Doppler Flowmetry in Type 2 Diabetic Patients ⬇️

Acute effect of beraprost sodium on lower limb circulation in patients with non-insulin-dependent diabetes mellitus-evaluation by color Doppler ultrasonography and laser cutaneous blood flowmetry.

Acute gliclazide administration enhances glucose and ketone body utilization in the perfused hind limb of normal and streptozotocin-diabetic rats

Administration of biotin prevents the development of insulin resistance in the skeletal muscles of Otsuka Long-Evans Tokushima fatty rats

Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation.

Affinity-based elimination of aromatic VOCs by highly crystalline multi-walled carbon nanotubes

Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients

Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles.

Alcohol consumption and risk of atrial fibrillation: a meta-analysis

Alcohol use and diabetes mellitus

Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats.

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity.

Analysis of the TNF receptor on KYM cells by binding assay and affinity cross-linking

Anti-tumor effect and mechanism of action of the tumor necrosis factor (TNF)

Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy

Antitumor effect of the tumor necrosis factor against various types of human cancer cells

Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells

Antitumor synergism between recombinant human tumor necrosis factor and recombinant human interferon-r

Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength

Are serum cholesterol levels associated with silent brain infarcts? The Seiryo Clinic Study

Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes

Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS).

Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis.

Association between remission of macroalbuminuria and preservation of renal function in patients with type 2 diabetes with overt proteinuria.

Association between serum uric acid and development of type 2 diabetes.

Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis

Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up

Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin

Association of living alone with the presence of undiagnosed diabetes in Japanese men: the role of modifiable risk factors for diabetes: Toranomon Hospital Health Management Center Study 13 (TOPICS 13).

Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias ⬇️

Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages

Attenuation of weight loss through improved antilipolytic effect in adipose tissue via the SGLT2 inhibitor tofogliflozin

Aurisides A and B, Cytotoxic Macrolide Glycosides from the Japanese Sea Hare Dolabella auricularia

BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens

Background to discuss guidelines for control of plasma HDL-cholesterol in Japan

Biotin Administration Improves the Impaired Glucose Tolerance of Streptozotocin-Induced Diabetic Wistar Rats ⬇️

Biotin augments acetyl CoA carboxylase 2 gene expression in the hypothalamus, leading to the suppression of food intake in mice

Biotin enhances ATP synthesis in pancreatic islets of the rat, resulting in reinforcement of glucose-induced insulin secretion

Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat.

Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance

Body Flexibility and Incident Hypertension: The Niigata Wellness Study

Body mass index and mortality among Japanese patients with type 2 diabetes: pooled analysis of the Japan diabetes complications study and the Japanese elderly diabetes intervention trial

Body weight change and type 2 diabetes.

Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase.

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women.

Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis

Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus

Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus.

Cell cycle specificity of tumor necrosis factor and its receptor