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List of works by Michal Hocek

2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA

scientific article published on 06 September 2018

2-Formyl-dATP as Substrate for Polymerase Synthesis of Reactive DNA Bearing an Aldehyde Group in the Minor Groove

scientific article published on 01 June 2020

2-Substituted 2'-deoxyinosine 5'-triphosphates as substrates for polymerase synthesis of minor-groove-modified DNA and effects on restriction endonuclease cleavage

scientific article published on 01 January 2020

2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.

scientific article

2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove.

scientific article published on 23 November 2016

5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase.

scientific article published on 29 November 2017

5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs.

scientific article published on 26 September 2016

6-Aryl-4-amino-pyrimido[4,5-b]indole 2'-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study.

scientific article

7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action.

scientific article published on 27 January 2016

7-Aryl-7-deazaadenine 2'-deoxyribonucleoside triphosphates (dNTPs): better substrates for DNA polymerases than dATP in competitive incorporations

scientific article

A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy

scientific article published on 19 November 2015

A facile and efficient synthesis of (Purin-6-yl)alanines

scientific article published in November 2004

A general and efficient synthesis of pyridin-2-yl C-ribonucleosides bearing diverse alkyl, aryl, amino, and carbamoyl groups in position 6.

scientific article published in January 2010

A modular approach to aryl-C-ribonucleosides via the allylic substitution and ring-closing metathesis sequence. a stereocontrolled synthesis of all four α-/β- and D-/L-C-nucleoside stereoisomers

scientific article published on 29 August 2011

Additions of Thiols to 7-Vinyl-7-deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2'-Deoxyadenosine, dATP and DNA

scientific article published on 14 October 2016

Alkylsulfanylphenyl derivatives of cytosine and 7-deazaadenine nucleosides, nucleotides and nucleoside triphosphates: synthesis, polymerase incorporation to DNA and electrochemical study

scientific article

Aminophenyl- and nitrophenyl-labeled nucleoside triphosphates: synthesis, enzymatic incorporation, and electrochemical detection

scientific article published in January 2008

An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR

scientific article published on 01 January 2007

An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines

scientific article published on July 2003

Anthraquinone as a redox label for DNA: synthesis, enzymatic incorporation, and electrochemistry of anthraquinone-modified nucleosides, nucleotides, and DNA.

scientific article

Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses

scientific article published on 04 January 2021

Aqueous Heck cross-coupling preparation of acrylate-modified nucleotides and nucleoside triphosphates for polymerase synthesis of acrylate-labeled DNA.

scientific article

Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions.

scientific article published on 16 September 2014

Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA-Protein Cross-Linking

scientific article published on 17 September 2015

B family DNA polymerases asymmetrically recognize pyrimidines and purines

scientific article

Base-modified DNA labeled by [Ru(bpy)(3)](2+) and [Os(bpy)(3)](2+) complexes: construction by polymerase incorporation of modified nucleoside triphosphates, electrochemical and luminescent properties, and applications.

scientific article published in January 2009

Benzofurazane as a new redox label for electrochemical detection of DNA: towards multipotential redox coding of DNA bases

scientific article published on 9 August 2013

Bodipy-labeled nucleoside triphosphates for polymerase synthesis of fluorescent DNA.

scientific article

Brightly Fluorescent 2'-Deoxyribonucleoside Triphosphates Bearing Methylated Bodipy Fluorophore for in Cellulo Incorporation to DNA, Imaging, and Flow Cytometry

scientific article published on 02 November 2018

C-H Imidation of 7-Deazapurines

scientific article published on 27 April 2018

C-H Phosphonation of Pyrrolopyrimidines: Synthesis of Substituted 7- and 9-Deazapurine-8-phosphonate Derivatives

scientific article published on 29 September 2016

C-nucleosides: synthetic strategies and biological applications.

scientific article

Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins

scientific article published in August 2016

Cleavage of DNA containing 5-fluorocytosine or 5-fluorouracil by type II restriction endonucleases

scientific article published on 10 October 2015

Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases

scientific article

Cleavage of functionalized DNA containing 5-modified pyrimidines by type II restriction endonucleases

scientific article published on 14 January 2011

Cocyclotrimerization of 6-alkynylpurines with alpha,omega-diynes as a novel approach to biologically active 6-arylpurines.

scientific article published in December 2004

Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides

scientific article published in October 2016

Correction to "Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides"

scientific article published on 25 January 2019

Covalent analogues of DNA base-pairs and triplets. Part 2: synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds

scientific article published in April 2002

Covalent analogues of nucleobase-pairs

scientific article published in May 2003

Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids.

scientific article published on 02 April 2008

Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines

scientific article published in 2006

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides

scientific article published on September 2005

Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: synthesis and evaluation of 6-substituted purine l-ribonucleosides

scientific article published on 14 August 2006

Direct C-H arylation of purines: development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines

scientific article published on 01 November 2006

Direct C-H borylation and C-H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines

scientific article published on 14 January 2009

Direct C-H sulfenylation of purines and deazapurines

scientific article published on 2 July 2013

Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose

scientific article published on 10 September 2015

Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines

scientific article published on 01 February 2010

Dual redox labeling of DNA as a tool for electrochemical detection of p53 protein-DNA interactions

scientific article published on 26 October 2018

Duplex Electrochemical DNA Sensor to Detect Bacillus anthracis CAP and PAG DNA Targets Based on the Incorporation of Tailed Primers and Ferrocene-Labeled dATP

scientific article published on 11 December 2019

Effect of spin-orbit coupling on reduction potentials of octahedral ruthenium(II/III) and osmium(II/III) complexes

scientific article published on 23 July 2008

Electrochemical genosensor for the direct detection of tailed PCR amplicons incorporating ferrocene labelled dATP

scientific article published on 30 March 2019

Enzymatic Synthesis of Base-Functionalized Nucleic Acids for Sensing, Cross-linking, and Modulation of Protein-DNA Binding and Transcription

scientific article published on 05 June 2019

Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates

scientific article published on 01 August 2018

Exceptional thermodynamic stability of DNA duplexes modified by nonpolar base analogues is due to increased stacking interactions and favorable solvation: Correlated ab initio calculations and molecular dynamics simulations.

scientific article published in April 2006

Facile and efficient synthesis of 6-(hydroxymethyl)purines

scientific article published on 01 September 2004

Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines

scientific article published on April 2004

Ferrocenylethynyl derivatives of nucleoside triphosphates: synthesis, incorporation, electrochemistry, and bioanalytical applications

scientific article published on 01 January 2007

Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition

scientific article published on 13 June 2018

Flexible double-headed cytosine-linked 2'-deoxycytidine nucleotides. Synthesis, polymerase incorporation to DNA and interaction with DNA methyltransferases.

scientific article

Fluorescence quenching in oligonucleotides containing 7-substituted 7-deazaguanine bases prepared by the nicking enzyme amplification reaction

scientific article published on 29 January 2015

Furan-oxidation-triggered inducible DNA cross-linking: acyclic versus cyclic furan-containing building blocks--on the benefit of restoring the cyclic sugar backbone

scientific article

GFP-like fluorophores as DNA labels for studying DNA-protein interactions.

scientific article

General and modular synthesis of isomeric 5-substituted pyridin-2-yl and 6-substituted pyridin-3-yl C-ribonucleosides bearing diverse alkyl, aryl, hetaryl, amino, carbamoyl, and hydroxy groups

scientific article published on 25 July 2011

Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity

scientific article published in January 2007

Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases

scientific article (publication date: 20 April 2016)

Inhibition of non-templated nucleotide addition by DNA polymerases in primer extension using twisted intercalating nucleic acid modified templates

scientific article published on 11 December 2015

Interpretation of indirect nuclear spin-spin couplings in isomers of adenine: novel approach to analyze coupling electron deformation density using localized molecular orbitals

scientific article published in June 2010

Interpretation of substituent effects on 13C and 15N NMR chemical shifts in 6-substituted purines

scientific article

Intramolecular direct C-H arylation approach to fused purines. Synthesis of purino[8,9-f]phenanthridines and 5,6-dihydropurino[8,9-a]isoquinolines

scientific article published in April 2010

Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate

scientific article published on February 2010

Modular and practical synthesis of 6-substituted pyridin-3-yl C-nucleosides

scientific article published on 01 August 2007

Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2'-deoxyribose C-nucleosides

scientific article published on 25 July 2011

Modular synthesis of 5-substituted thiophen-2-yl C-2'-deoxyribonucleosides

scientific article published on 17 April 2008

Nucleobase modification as redox DNA labelling for electrochemical detection

scientific article published on 31 May 2011

Nucleobase protection strategy for gene cloning and expression

scientific article published on 26 March 2013

Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication

scientific article

Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids

scientific article published on 19 December 2019

Phenothiazine-linked nucleosides and nucleotides for redox labelling of DNA.

scientific article published on 9 August 2017

Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides.

scientific article published on 4 December 2010

Photocaged 5-(Hydroxymethyl)pyrimidine Nucleoside Phosphoramidites for Specific Photoactivatable Epigenetic Labeling of DNA

scientific article published on 06 November 2020

Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine Nucleobases

scientific article published on 18 September 2015

Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins

scientific article

Polymerase synthesis of DNAs bearing vinyl groups in the major groove and their cleavage by restriction endonucleases

scientific article published in September 2014

Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling.

scientific article published on 12 April 2013

Polymerase synthesis of photocaged DNA resistant against cleavage by restriction endonucleases

scientific article

Preparation of highly substituted 6-arylpurine ribonucleosides by Ni-catalyzed cyclotrimerization. Scope of the reaction

scientific article published on 01 November 2006

Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction

scientific article published on 29 May 2012

Protected 2'-deoxyribonucleoside triphosphate building blocks for the photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA

scientific article published on 01 August 2018

Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA.

scientific article published on 12 February 2018

Purines Bearing Phenanthroline or Bipyridine Ligands and Their RuII Complexes in Position 8 as Model Compounds for Electrochemical DNA Labeling – Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antivira

article

Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

scientific article published on 23 August 2017

Regioselective direct C-H arylations of protected uracils. Synthesis of 5- and 6-aryluracil bases

scientific article published on 26 May 2011

Scope and limitations of the nicking enzyme amplification reaction for the synthesis of base-modified oligonucleotides and primers for PCR.

scientific article

Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions

scientific article

Squaramate-Modified Nucleotides and DNA for Specific Cross-Linking with Lysine-Containing Peptides and Proteins

scientific article published on 13 August 2019

Strategies toward protecting group-free glycosylation through selective activation of the anomeric center.

scientific article

Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides

scientific article

Sugar modified pyrimido[4,5-]indole nucleosides: synthesis and antiviral activity

scientific article published on 25 August 2017

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides

scientific article

Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA

scientific article published on 04 March 2019

Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines

Synthesis and Cytostatic and Antiviral Activities of 2′‐Deoxy‐2′,2′‐difluororibo‐ and 2′‐Deoxy‐2′‐fluororibonucleosides Derived from 7‐(Het)aryl‐7‐deazaadenines ⬇️

scientific article published on April 4, 2013

Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides.

scientific article published on 21 February 2017

Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-fused 7-Deazapurine Ribonucleosides

scientific article published on 3 October 2018

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

scientific article

Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides.

scientific article published on 17 June 2013

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides.

scientific article published on 31 October 2015

Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids

scientific article published on 01 May 2000

Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7.

scientific article

Synthesis and photophysical properties of biaryl-substituted nucleos(t)ides. Polymerase synthesis of DNA probes bearing solvatochromic and pH-sensitive dual fluorescent and 19F NMR labels

scientific article

Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions.

scientific article published on 31 July 2007

Synthesis of 2,6-disubstituted pyridin-3-yl C-2'-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides.

scientific article

Synthesis of 6,8,9-tri- and 2,6,8,9-tetrasubstituted purines by a combination of the Suzuki cross-coupling, N-arylation, and direct C-H arylation reactions

scientific article

Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA.

scientific article

Synthesis of C-aryldeoxyribosides by [2 + 2 + 2]-cyclotrimerization catalyzed by Rh, Ni, Co, and Ru complexes

scientific article published on 01 May 2006

Synthesis of Dihydroxyalkynyl and Dihydroxyalkyl Nucleotides as Building Blocks or Precursors for Introduction of Diol or Aldehyde Groups to DNA for Bioconjugations

scientific article published on 19 June 2018

Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism

scientific article published on 23 January 2017

Synthesis of acetylene linked double-nucleobase nucleos(t)ide building blocks and polymerase construction of DNA containing cytosines in the major groove

scientific article published on 22 March 2011

Synthesis of aldehyde-linked nucleotides and DNA and their bioconjugations with lysine and peptides through reductive amination

scientific article published on 15 February 2012

Synthesis of base-modified 2'-deoxyribonucleoside triphosphates and their use in enzymatic synthesis of modified DNA for applications in bioanalysis and chemical biology

scientific article published on 21 October 2014

Synthesis of enantiomerically pure (purin-6-yl)phenylalanines and their nucleosides, a novel type of purine-amino acid conjugates

scientific article published in September 2005

Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA.

scientific article published on 15 January 2010

Synthesis of nucleoside mono- and triphosphates bearing oligopyridine ligands, their incorporation into DNA and complexation with transition metals

scientific article published on 09 November 2011

Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations

Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations

scientific article

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

scientific article published on 29 November 2007

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides

scientific article published on 23 October 2007

Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides

scientific article published on 16 January 2014

Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet

scientific article

Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl transferase. Application in electrochemical DNA hybridization and protein-DNA binding assays.

scientific article

The first direct C-H arylation of purine nucleosides

scientific article published on 25 October 2007

The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

scientific article published on 4 July 2005

Theoretical study of the stability of the DNA duplexes modified by a series of hydrophobic base analogues.

scientific article published in August 2009

Thiophene-linked tetramethylbodipy-labeled nucleotide for viscosity-sensitive oligonucleotide probes of hybridization and protein-DNA interactions

scientific article published on 10 January 2020

Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases

scientific article published on 29 July 2011

Trifluoroacetophenone-Linked Nucleotides and DNA for Studying of DNA-Protein Interactions by 19F NMR Spectroscopy

scientific article

Tuning of Oxidation Potential of Ferrocene for Ratiometric Redox Labeling and Coding of Nucleotides and DNA

scientific article published on 09 January 2020

Turning off transcription with bacterial RNA polymerase through CuAAC click reactions of DNA containing 5-ethynyluracil.

scientific article published on 14 April 2018

Understanding the NMR chemical shifts for 6-halopurines: role of structure, solvent and relativistic effects

scientific article published on 29 March 2010

Vicinal Diol-Tethered Nucleobases as Targets for DNA Redox Labeling with Osmate Complexes

scientific article published on 13 August 2019

Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins

scientific article published on 12 August 2013

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