List of works - Kevin G. Pinney

2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)indole.

scientific article published on 21 May 2002

A new anti-tubulin agent containing the benzo[b]thiophene ring system

scientific article published on 01 April 1999

A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment

scientific article

An amino-benzosuberene analogue that inhibits tubulin assembly and demonstrates remarkable cytotoxicity ⬇️

scientific article published on June 1, 2012

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

scientific article published on 20 March 2020

Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia.

scientific article published in December 2016

Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.

scientific article published on 28 February 2008

Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis

scientific article published in September 2004

Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy

scientific article

Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease

scientific article

Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents

scientific article published on 25 January 2006

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

scientific article

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents

scientific article published on 6 January 2016

Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

scientific article published on 24 July 2008

Development of synthetic methodology suitable for the radiosynthesis of combretastatin A-1 (CA1) and its corresponding prodrug CA1P.

scientific article published in March 2009

Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks

scientific article published on 16 December 2018

Efficient and selective photoaffinity labeling of the estrogen receptor using two nonsteroidal ligands that embody aryl azide or tetrafluoroaryl azide photoreactive functions

scientific article published on March 1991

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

scientific article published on 15 September 2010

Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research

scientific article published on 14 August 2018

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L ⬇️

scientific article published on October 29, 2012

Mechanistic Considerations in the Synthesis of 2-Aryl-Indole Analogues under Bischler-Mohlau Conditions

scientific article published on June 2015

Molecular structures, conformational analysis, and preferential modes of binding of 3-aroyl-2-arylbenzo[b]thiophene estrogen receptor ligands: LY117018 and aryl azide photoaffinity labeling analogs

scientific article published on 01 November 1993

Nonsteroidal estrogens bearing acyl azide functions: potential electrophilic and photoaffinity labeling agents for the estrogen receptor

scientific article published on 01 May 1992

Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha, beta-unsaturated sulfoxide.

scientific article published in December 2000

Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1.

scientific article published in June 2010

Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1 ⬇️

scientific article published on June 30, 2011

Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.

scientific article published on 20 December 2012

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization

scientific article published on 22 October 2015

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

scientific article published on 24 May 2019

Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.

scientific article published on 22 September 2016

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.

scientific article published on 25 September 2015

Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.

scientific article

Synthesis and biological evaluation of 2-(4-fluorophenoxy)-2-phenyl-ethyl piperazines as serotonin-selective reuptake inhibitors with a potentially improved adverse reaction profile

scientific article published in March 2004

Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.

scientific article published on 21 December 2016

Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin

scientific article

Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)

scientific article published on 23 July 2013

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues

scientific article published on 04 June 2019

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent

scientific article published on 09 September 2013

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

scientific article published on 24 August 2018

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.

scientific article published on 04 September 2013

Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.

scientific article published on May 2003

Target tissue uptake selectivity of three fluorine-substituted progestins: potential imaging agents for receptor-positive breast tumors

scientific article

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.

scientific article published on 28 August 2015

Torsionally and hydrophobically modified 2,3-diarylindenes as estrogen receptor ligands

scientific article published on 01 October 1990

[3H]DU41165: A high affinity ligand and novel photoaffinity labeling reagent for the progesterone receptor

scientific article published on 01 February 1990

List of works by Kevin G. Pinney

2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)indole.

A new anti-tubulin agent containing the benzo[b]thiophene ring system

A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment

An amino-benzosuberene analogue that inhibits tubulin assembly and demonstrates remarkable cytotoxicity ⬇️

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia.

Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.

Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis

Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy

Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease

Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents

Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

Development of synthetic methodology suitable for the radiosynthesis of combretastatin A-1 (CA1) and its corresponding prodrug CA1P.

Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks

Efficient and selective photoaffinity labeling of the estrogen receptor using two nonsteroidal ligands that embody aryl azide or tetrafluoroaryl azide photoreactive functions

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L ⬇️

Mechanistic Considerations in the Synthesis of 2-Aryl-Indole Analogues under Bischler-Mohlau Conditions

Molecular structures, conformational analysis, and preferential modes of binding of 3-aroyl-2-arylbenzo[b]thiophene estrogen receptor ligands: LY117018 and aryl azide photoaffinity labeling analogs

Nonsteroidal estrogens bearing acyl azide functions: potential electrophilic and photoaffinity labeling agents for the estrogen receptor

Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha, beta-unsaturated sulfoxide.

Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1.

Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1 ⬇️

Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.

Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.

Synthesis and biological evaluation of 2-(4-fluorophenoxy)-2-phenyl-ethyl piperazines as serotonin-selective reuptake inhibitors with a potentially improved adverse reaction profile

Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.

Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin

Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.

Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.

Target tissue uptake selectivity of three fluorine-substituted progestins: potential imaging agents for receptor-positive breast tumors

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.

Torsionally and hydrophobically modified 2,3-diarylindenes as estrogen receptor ligands

[3H]DU41165: A high affinity ligand and novel photoaffinity labeling reagent for the progesterone receptor