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List of works by Yung H. Wong

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

scientific article published on 26 November 2010

A hematopoietic perspective on the promiscuity and specificity of Galpha16 signaling.

scientific article published on 12 February 2009

A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine

scientific article

AGS3 and Gαi3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells

scientific article published on 06 November 2020

Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.

scientific article published in November 2012

Activation of STAT3 by specific Galpha subunits and multiple Gbetagamma dimers.

scientific article

Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells

scientific article published on 23 June 2005

Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src

scientific article published on 22 August 2005

Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cells

scientific article published on 17 August 2007

Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.

scientific article

Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).

scientific article

Alanine-23 of transducin alpha subunit is involved in defining the affinity for betagamma complex.

scientific article published in June 1999

Alanine-23 of transducin alpha subunit is involved in defining the affinity for betagammma complex

scientific article published on May 1999

Angiotensin-[1-12] interacts with angiotensin type I receptors

scientific article published on 30 June 2013

Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac

scientific article

Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ

scientific article

Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.

scientific article published on 14 November 2011

BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates.

scientific article

CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Gα(14/16) signaling and IL-6 release

scientific article published on 02 November 2012

CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades

scientific article published on 17 August 2009

CKBM stimulates MAPKs but inhibits LPS-induced IFN-gamma in lymphocytes

scientific article published on September 2006

Carvacrol and eugenol differentially stimulate intracellular Ca2+ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells

scientific article published in July 2005

Changes in the proteome and phosphoproteome expression in the bryozoan Bugula neritina larvae in response to the antifouling agent butenolide ⬇️

scientific article published on October 1, 2010

Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells

scientific journal article

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

article published in 2012

Chimeric Galpha(q) mutants harboring the last five carboxy-terminal residues of Galpha(i2) or Galpha(o) are resistant to pertussis toxin-catalyzed ADP-ribosylation.

scientific article

Comparative glycoproteome analysis: dynamics of protein glycosylation during metamorphic transition from Pelagic to Benthic life stages in three invertebrates.

scientific article published on 15 December 2011

Constitutive activation of the opioid receptor-like (ORL1) receptor by mutation of Asn133 to tryptophan in the third transmembrane region

scientific article published on December 2002

Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism

scientific article published on 9 October 2003

Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade

scientific article published on June 2006

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms.

scientific article published on 24 June 2011

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management

scientific article

Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability

scientific article

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways.

scientific article published on 31 March 2016

Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation

scientific article published on 29 January 2009

Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Galpha 14-coupled pathways

scientific article published on March 2004

Differential involvement of Galpha16 in CC chemokine-induced stimulation of phospholipase Cbeta, ERK, and chemotaxis

scientific article

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress

scientific article published on January 2007

Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity

scientific article published in June 2004

Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G(z) and G(12) proteins

scientific article published in July 2000

Expression of G protein beta subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling

scientific article published on 19 March 2007

Expression of Gα(z) in C2C12 cells restrains myogenic differentiation.

scientific article published on 12 October 2010

Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts

scientific article published on 25 March 2016

Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1alpha in human U87 astrocytoma cells

scientific article

Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-kappa B kinase in human U87 astrocytoma cells

scientific article published on 28 August 2007

G protein signaling controls the differentiation of multiple cell lineages.

scientific article published on May 2009

G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis.

scientific article published on 19 October 2007

GABAB heterodimeric receptors promote Ca2+ influx via store-operated channels in rat cortical neurons and transfected Chinese hamster ovary cells

scientific article

Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS).

scientific article published on October 2010

Galpha16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling.

scientific article

Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C.

scientific article

Gbetagamma signaling and Ca2+ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by Gq-coupled receptors

scientific article published on July 2004

Gi assays in transfected cells

scientific article published on January 1994

Glial cells isolated from dorsal root ganglia express prostaglandin E(2) (EP(4)) and prostacyclin (IP) receptors

scientific article published on 28 April 2011

Gq-mediated activation of c-Jun N-terminal kinase by the gastrin-releasing peptide-preferring bombesin receptor is inhibited upon costimulation of the Gs-coupled dopamine D1 receptor in COS-7 cells

scientific article published in August 2005

Gz coupling to the rat kappa-opioid receptor

scientific article

Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms.

scientific article published on 5 April 2013

Immuno-regulatory effects of CKBM on the activities of mitogen-activated protein kinases and the release of cytokines in THP-1 monocytic cells

scientific article published on September 2005

In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator

scientific article published on 22 September 2010

Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells

scientific article published on 30 June 2005

Integration of signals from receptor tyrosine kinases and g protein-coupled receptors.

scientific article

Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation.

scientific article published on 28 September 2011

Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons

scientific article published on 30 December 2004

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

scientific article published in February 2013

Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells

scientific article (publication date: July 2004)

Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways.

scientific article published on 7 March 2014

Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins

scientific article published in March 2002

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis.

scientific article published on 3 March 2015

Molecular basis of opioid dependence: role of signal regulation by G-proteins

scientific article

Molecular determinants for the differential coupling of Galpha(16) to the melatonin MT1, MT2 and Xenopus Mel1c receptors

scientific article

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression

scientific article

Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cells

scientific article published on January 2005

Multiple Gi proteins participate in nerve growth factor-induced activation of c-Jun N-terminal kinases in PC12 cells

scientific article published on 14 November 2008

Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function

scientific article published on 23 July 2020

Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors

scientific article published on 22 November 2008

NRG induces membrane targeting of Galphaz in muscle: implication in myogenesis.

scientific article published on September 2007

Naturally occurring phenylethanoid glycosides: potential leads for new therapeutics.

scientific article published on January 2008

Nerve growth factor-induced differentiation of PC12 cells is accompanied by elevated adenylyl cyclase activity.

scientific article published on 14 April 2010

Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G(i/o) proteins

scientific article published on 18 April 2008

Opioid receptor-like (ORL1) receptor utilizes both G(oA) and G(oB) for signal transduction.

scientific article published on January 2006

Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells.

scientific article

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

scientific article published on 30 May 2012

Phosphatidylinositol-3 kinase is distinctively required for mu-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase

scientific article

Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia.

scientific article

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling.

scientific article published on February 2016

Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.

scientific article published on 24 June 2005

Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Galpha(s) and Galpha(16) hybrid signaling

scientific article

Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2.

scientific article

Prostanoid signal integration and cross talk.

scientific article

Quantitative proteomics identify molecular targets that are crucial in larval settlement and metamorphosis of Bugula neritina.

scientific article published on 16 December 2010

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras.

scientific article

RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.

scientific article published on 25 June 2011

Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor

scientific article published on February 2003

Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues

scientific article published on 26 June 2012

Regulation of STAT3 activity by G16-coupled receptors

scientific article published on April 2003

Regulation of STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cells

scientific article published on June 2004

Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor

scientific article

Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells.

scientific article

Regulation of transcription factors by heterotrimeric G proteins.

scientific article published on January 2009

Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis.

scientific article published on 30 July 2013

Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion.

scientific article published on 2 August 2016

Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives

scientific article

Reporter gene assays and their applications to bioassays of natural products.

scientific article

Reporter gene assays.

scientific article published in January 2009

Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells

scientific article

Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates

scientific article

Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins

scientific article

Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants

scientific article published in February 1999

Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands

scientific article

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands.

scientific article published on 25 February 2010

The ORL1 receptor: molecular pharmacology and signalling mechanisms

scientific article

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Galpha(16) and inhibits the canonical phospholipase Cbeta pathway.

scientific article published on 5 April 2009

The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappaB in Jurkat T-cells and THP-1 monocytic cells

scientific article published on 01 January 2006

The cyclic AMP-mediated expression of acetylcholinesterase in myotubes shows contrasting activation and repression between avian and mammalian enzymes.

scientific article published in April 2001

The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with Galpha16.

scientific article

The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteins

scientific article published on March 1995

The role of glial cells in influencing neurite extension by dorsal root ganglion cells

scientific article published on 22 December 2009

Transcriptional activation of c-Fos by constitutively active Galpha(16)QL through a STAT1-dependent pathway

scientific article published on 9 May 2006

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