List of works - Jared Sterneckert

4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells

scientific article

A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits

scientific article published on 08 October 2019

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation

scientific article published on 06 April 2018

Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

scientific article published on 06 April 2022

Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations

scientific article published on 01 September 2019

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.

scientific article published on 03 March 2017

Bone morphogenetic proteins produced by cells within embryoid bodies inhibit ventral directed differentiation by Sonic Hedgehog.

scientific article published in January 2005

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons

scientific article published on 10 October 2016

Concise Review: Oct4 and More: The Reprogramming Expressway ⬇️

scientific article published on January 1, 2012

Correction: Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling

scientific article published on 03 August 2018

Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling

scientific article

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction

scientific article published on 23 August 2017

Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay

scientific article

Discovery of neuritogenic compound classes inspired by natural products

scientific article

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

scientific article published on 04 October 2019

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

scientific article published on 2 July 2015

Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features

scientific article

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

scientific article published on 14 February 2019

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

scientific article published on 26 January 2018

Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury

scientific article published in April 2010

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

scientific article published on 01 April 2019

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

scientific article

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

scientific article published on March 2013

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

scientific article published on 11 October 2017

Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes

scientific article published on 01 April 2013

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

scientific article published on 19 March 2021

Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway

scientific article

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

scientific article

Investigating human disease using stem cell models

scientific article

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

scientific article

Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells

scientific article

Modeling Parkinson's disease in midbrain-like organoids

scientific article published on 05 April 2019

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

scientific article published on 06 December 2019

Neural induction intermediates exhibit distinct roles of Fgf signaling.

scientific article published in October 2010

Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization.

scientific article published on November 2016

Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain.

scientific article

Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses

scientific article published on 01 January 2019

Primary Spinal OPC Culture System from Adult Zebrafish to Study Oligodendrocyte Differentiation In Vitro

scientific article published on 14 September 2017

RNA buffers the phase separation behavior of prion-like RNA binding proteins.

scientific article published on 12 April 2018

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.

scientific article published on 28 February 2017

Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging

scientific article published on 4 August 2015

Structural binding site comparisons reveal Crizotinib as a novel LRRK2 inhibitor

scientific article published on 10 June 2021

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner

scientific article published on 22 October 2019

Zfp296 is a novel, pluripotent-specific reprogramming factor

scientific article

iPS cell derived neuronal cells for drug discovery

scientific article published on 03 August 2014

List of works by Jared Sterneckert

4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells

A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation

Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.

Bone morphogenetic proteins produced by cells within embryoid bodies inhibit ventral directed differentiation by Sonic Hedgehog.

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons

Concise Review: Oct4 and More: The Reprogramming Expressway ⬇️

Correction: Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling

Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction

Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay

Discovery of neuritogenic compound classes inspired by natural products

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Investigating human disease using stem cell models

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells

Modeling Parkinson's disease in midbrain-like organoids

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Neural induction intermediates exhibit distinct roles of Fgf signaling.

Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization.

Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain.

Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses

Primary Spinal OPC Culture System from Adult Zebrafish to Study Oligodendrocyte Differentiation In Vitro

RNA buffers the phase separation behavior of prion-like RNA binding proteins.

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.

Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging

Structural binding site comparisons reveal Crizotinib as a novel LRRK2 inhibitor

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner

Zfp296 is a novel, pluripotent-specific reprogramming factor

iPS cell derived neuronal cells for drug discovery