List of works - Sonsoles Martín-Santamaría

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

scientific article

Adrenomedullin: a new and promising target for drug discovery

scientific article published in April 2006

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

scientific article

Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

scientific article

Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

scientific article published on 25 September 2018

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance

scientific article published on 14 March 2017

Chemistry of lipid A: at the heart of innate immunity.

scientific article

Computational Approaches to Toll-Like Receptor 4 Modulation

scientific article

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.

scientific article

Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.

scientific article published on 17 September 2013

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin

scientific article

Diastereoselective reactions in glycine templates containing an ent-ardeemin fragment

scientific article

ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor

scientific article

Editorial :Chemistry Bordering Biology: highlights from the XXXIV Biennial Meeting of the RSEQ.

scientific article published in January 2014

Engineering O-Glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-Associated Glycopeptides

scientific article published on 08 February 2011

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

scientific article published on 18 October 2019

Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties.

scientific article published on 19 February 2016

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates

scientific article

Guanidinium receptors as enantioselective amino acid membrane carriers

scientific article published in July 2003

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

scientific article published on 26 June 2019

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

scientific article published on 31 August 2018

Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.

scientific article published on 24 October 2013

Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

scientific article published on 14 August 2018

MMP-2 selectivity in hydroxamate-type inhibitors.

scientific article published on January 2012

Mimicking chitin: chemical synthesis, conformational analysis, and molecular recognition of the beta(1-->3) N-acetylchitopentaose analogue

scientific article published in April 2010

Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood-Group Antigens by Human Galectin-3

scientific article published on 17 April 2019

Modulation of Binding Strength in Several Classes of Active Site Inhibitors of Acetylcholinesterase Studied by Comparative Binding Energy Analysis

article

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

scientific article

Modulation of toll-like receptor 4. Insights from x-ray crystallography and molecular modeling.

scientific article

Multisite-directed inhibitors of protein kinase CK2: new challenges.

scientific article

New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

scientific article published on 21 April 2020

New clicked full agonists of the estrogen receptor β

scholarly article in RSC Advances, vol. 3 no. 11, 2013

New scaffolds for the design of selective estrogen receptor modulators

scientific article

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

scientific article published in Scientific Reports

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

scientific article published on 06 May 2011

Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites ⬇️

scientific article published on January 5, 2012

Rational design of a Tn antigen mimic

scientific article published on 31 March 2011

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

scientific article published on January 2004

Selective human adenosine A3 antagonists based on pyrido[2,1-f]purine-2,4-diones: novel features of hA3 antagonist binding.

scientific article

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

scientific article published on 8 August 2014

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

scientific article

Structural aspects of binding of α-linked digalactosides to human galectin-1

scientific article published on 28 June 2011

Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products

scientific article

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

scientific article

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

scientific article published in March 2018

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

scientific article

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

scientific article published in June 2005

Towards β-selectivity in functional estrogen receptor antagonists

scientific article published on 01 September 2012

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

scientific article published on 9 September 2016

gem-Difluorocarbadisaccharides: Restoring theexo-Anomeric Effect

scientific article published on 15 July 2014

List of works by Sonsoles Martín-Santamaría

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

Adrenomedullin: a new and promising target for drug discovery

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance

Chemistry of lipid A: at the heart of innate immunity.

Computational Approaches to Toll-Like Receptor 4 Modulation

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.

Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin

Diastereoselective reactions in glycine templates containing an ent-ardeemin fragment

ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor

Editorial :Chemistry Bordering Biology: highlights from the XXXIV Biennial Meeting of the RSEQ.

Engineering O-Glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-Associated Glycopeptides

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties.

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates

Guanidinium receptors as enantioselective amino acid membrane carriers

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.

Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

MMP-2 selectivity in hydroxamate-type inhibitors.

Mimicking chitin: chemical synthesis, conformational analysis, and molecular recognition of the beta(1-->3) N-acetylchitopentaose analogue

Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood-Group Antigens by Human Galectin-3

Modulation of Binding Strength in Several Classes of Active Site Inhibitors of Acetylcholinesterase Studied by Comparative Binding Energy Analysis

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

Modulation of toll-like receptor 4. Insights from x-ray crystallography and molecular modeling.

Multisite-directed inhibitors of protein kinase CK2: new challenges.

New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

New clicked full agonists of the estrogen receptor β

New scaffolds for the design of selective estrogen receptor modulators

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites ⬇️

Rational design of a Tn antigen mimic

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

Selective human adenosine A3 antagonists based on pyrido[2,1-f]purine-2,4-diones: novel features of hA3 antagonist binding.

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

Structural aspects of binding of α-linked digalactosides to human galectin-1

Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

Towards β-selectivity in functional estrogen receptor antagonists

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

gem-Difluorocarbadisaccharides: Restoring theexo-Anomeric Effect