List of works - Beatriz de Pascual-Teresa

Adrenomedullin: a new and promising target for drug discovery

scientific article published in April 2006

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

scientific article

An integrated computational and experimental approach to gaining selectivity for MMP-2 within the gelatinase subfamily.

scientific article

Assessment of Solvation Effects on Calculated Binding Affinity Differences: Trypsin Inhibition by Flavonoids as a Model System for Congeneric Series

article

Azino-Fused Benzimidazolium Salts as DNA Intercalating Agents. 2

Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis

scientific article published in October 1993

Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family

scientific article published on 01 January 2015

Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders

scientific article published on 28 November 2017

Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action

scientific article published on February 2014

Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold

scientific article published on 17 August 2018

From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors

scientific article published on 01 January 2019

Human protein kinase CK2 phosphorylates matrix metalloproteinase 2 and inhibits its activity

scientific article

Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments

scientific article

In silico identification and in vivo characterization of small molecule therapeutic hypothermia mimetics.

scientific article published on 31 October 2017

Intercalators as anticancer drugs.

scientific article

MMP-2 selectivity in hydroxamate-type inhibitors.

scientific article published on January 2012

Molecular dynamics simulations of the bis-intercalated complexes of ditercalinium and Flexi-Di with the hexanucleotide d(GCGCGC)2: theoretical analysis of the interaction and rationale for the sequence binding specificity.

scientific article

Multisite-directed inhibitors of protein kinase CK2: new challenges.

scientific article

Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors

scientific article published on 25 March 2020

New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.

scientific article published on March 2004

New clicked full agonists of the estrogen receptor β

scholarly article in RSC Advances, vol. 3 no. 11, 2013

New scaffolds for the design of selective estrogen receptor modulators

scientific article

Novel DNA Intercalators Based on the Pyridazino[1‘,6‘:1,2]pyrido[4,3-b]indol-5-inium System

Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol.

scientific article

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

scientific article published on 06 May 2011

Progress towards water-soluble triazole-based selective MMP-2 inhibitors.

scientific article published on 30 August 2013

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases

scientific article published on November 2005

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

scientific article

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

scientific article

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

scientific article

Synthesis and DNA Binding Properties of γ-Carbolinium Derivatives and Benzologues

Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2.

scientific article published on 16 June 2004

Synthesis and cytotoxicity of hydrophobic esters of podophyllotoxins

scientific article published on March 2004

Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides.

scientific article published in December 2002

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

scientific article published in June 2005

Synthesis, cytotoxic activities and proposed mode of binding of a series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines

scientific article

Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors

scientific article published on 10 October 2014

alpha-Alkyl-alpha-Amino-beta-Lactam Peptides: Design, Synthesis, and Conformational Features.

scientific article

List of works by Beatriz de Pascual-Teresa

Adrenomedullin: a new and promising target for drug discovery

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

An integrated computational and experimental approach to gaining selectivity for MMP-2 within the gelatinase subfamily.

Assessment of Solvation Effects on Calculated Binding Affinity Differences: Trypsin Inhibition by Flavonoids as a Model System for Congeneric Series

Azino-Fused Benzimidazolium Salts as DNA Intercalating Agents. 2

Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis

Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family

Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders

Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action

Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold

From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors

Human protein kinase CK2 phosphorylates matrix metalloproteinase 2 and inhibits its activity

Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments

In silico identification and in vivo characterization of small molecule therapeutic hypothermia mimetics.

Intercalators as anticancer drugs.

MMP-2 selectivity in hydroxamate-type inhibitors.

Molecular dynamics simulations of the bis-intercalated complexes of ditercalinium and Flexi-Di with the hexanucleotide d(GCGCGC)2: theoretical analysis of the interaction and rationale for the sequence binding specificity.

Multisite-directed inhibitors of protein kinase CK2: new challenges.

Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors

New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.

New clicked full agonists of the estrogen receptor β

New scaffolds for the design of selective estrogen receptor modulators

Novel DNA Intercalators Based on the Pyridazino[1‘,6‘:1,2]pyrido[4,3-b]indol-5-inium System

Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol.

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

Progress towards water-soluble triazole-based selective MMP-2 inhibitors.

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

Synthesis and DNA Binding Properties of γ-Carbolinium Derivatives and Benzologues

Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2.

Synthesis and cytotoxicity of hydrophobic esters of podophyllotoxins

Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides.

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

Synthesis, cytotoxic activities and proposed mode of binding of a series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines

Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors

alpha-Alkyl-alpha-Amino-beta-Lactam Peptides: Design, Synthesis, and Conformational Features.