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List of works by Jesper Wengel

"Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies.

scientific article published in November 2013

2'-Spiro ribo- and arabinonucleosides: synthesis, molecular modelling and incorporation into oligodeoxynucleotides.

scientific article published on October 2003

2′-N-(Pyren-1-yl)acetyl-2′-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets

scientific article published on 01 July 2007

3'-C-Branched LNA-type nucleosides locked in an N-type furanose ring conformation: synthesis, incorporation into oligodeoxynucleotides, and hybridization studies

scientific article published in September 2004

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes

scientific article published on 17 February 2017

3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

scientific article published on 01 September 2002

A Novel Class of Oligonucleotide Analogues Containing 2‘-O,3‘-C-Linked [3.2.0]Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and Molecular Modeling

scientific article published in 1998

A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids

scientific article published on 24 October 2013

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

scientific article

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

scientific article published on 12 March 2009

A locked nucleic acid-based nanocrawler: designed and reversible movement detected by multicolor fluorescence.

scientific article published on 8 February 2013

A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid).

scientific article published in May 2013

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

scientific article

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

scientific article published on 13 April 2019

A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.

scientific article published on January 2003

ADAMTS-targeting gapmers as a gene modulation strategy in osteoarthritis

scientific article published in April 2020

Adsorption and surface dynamics of short DNA and LNA oligonucleotides on single-crystal Au(111) electrode surfaces

Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics

scientific article published on 01 January 2020

Alpha-L-RNA (alpha-L-ribo configured RNA): synthesis and RNA-selective hybridization of alpha-L-RNA/alpha-L-LNA chimera.

scientific article

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

scientific article published on 31 March 2020

Amino acids attached to 2'-amino-LNA: synthesis and excellent duplex stability.

scientific article

Amplification and re-generation of LNA-modified libraries

scientific article published on 5 November 2012

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

scientific article

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

scientific article published on 12 April 2016

Anti-invasive activity of alkaloids and polyphenolics in vitro

scientific article published on 01 August 1997

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

scientific article published on 12 March 2016

Aryl-β-C-LNA Monomers as Universal Hybridization Probes[1] [2]

scientific article published on 01 May 2003

Biocatalytic Separation ofN-7/N-9 Guanine Nucleosides

Biological activity and biotechnological aspects of locked nucleic acids.

scientific article published on January 2013

Bis-Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Hybridization Studies, and Fluorescent Properties

scientific article published on 18 July 2014

Boronic acid-based autoligation of nucleic acids: influence of the nature of the 3′-end ribonucleotidic strand

article

Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene–perylene 2′-α-l-amino-LNA FRET pairs

scientific article published on 01 January 2013

Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch

scientific article published on 01 August 2000

Brightness through local constraint--LNA-enhanced FIT hybridization probes for in vivo ribonucleotide particle tracking

scientific article published on 28 August 2014

By-product formation in repetitive PCR amplification of DNA libraries during SELEX.

scientific article published on 9 December 2014

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.

scientific article published on 17 February 2017

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

scientific article published on 3 April 2021

Carbazole modified oligonucleotides: synthesis, hybridization studies and fluorescence properties

scientific article published on 02 September 2020

Chemical fidelity of an RNA polymerase ribozyme

article by James Attwater et al published 2013 in Chemical Science

Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases

scientific article published on 06 June 2012

Conformationally controlled high-affinity targeting of RNA or DNA by novel 2′-amino-DNA/LNA mixmers and pyrenyl-functionalized 2′-amino-DNA

article

Convenient Syntheses of 7-Hydroxy-1-(hydroxymethyl)- 3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptanes: α-l-Ribo- and α-l-Xylo-Configured LNA Nucleosides

scientific article published on 01 August 2000

Corrigendum: Interfacing Click Chemistry with Automated Oligonucleotide Synthesis for the Preparation of Fluorescent DNA Probes Containing Internal Xanthene and Cyanine Dyes

scholarly article published in Chemistry—A European Journal

DNA and LNA oligonucleotides containing N2′-functionalised derivatives of 2′-amino-2′-deoxyuridine

scientific article published on 18 April 2006

DNA self-assembling systems: branched oligonucleotides as building blocks and monitoring by pyrene excimer band formation

scientific article

David versus Goliath

scientific article published on 22 April 2010

Deacylation studies on furanose triesters using an immobilized lipase: Synthesis of a key precursor for bicyclonucleosides

scientific article published on 27 March 2007

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs.

scientific article

Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3.

scientific article published on 6 August 2008

Detection and discrimination of biofilm populations using locked nucleic acid/2′-O-methyl-RNA fluorescence in situ hybridization (LNA/2′OMe-FISH)

scholarly article by Andreia S M Azevedo et al published December 2015 in Biochemical Engineering Journal

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.

scientific article published on 2 February 2017

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.

scientific article published on 23 January 2013

Direct imaging of hexaamine-ruthenium(III) in domain boundaries in monolayers of single-stranded DNA.

scientific article published on January 2007

Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.

scientific article

Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

scientific article published on 01 January 2007

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

scientific article

Effective Modulation of DNA Duplex Stability by Reversible Transition Metal Complex Formation in the Minor Groove

scientific article published on 07 July 2007

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase

scientific article

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

scientific article

Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers

scientific article

Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces

scientific article published in May 2020

Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces

scientific article

Electrochemistry of single metalloprotein and DNA-based molecules at Au(111) electrode surfaces.

scientific article published on 20 June 2013

Electron injection from the side of an M-DNA duplex

scientific article published on 3 December 2005

Enhanced Inhibition of Transcription Start by Targeting with 2′-OMe Pentaribonucleotides Comprising Locked Nucleic Acids and Intercalating Nucleic Acids

scientific article published on 01 July 2005

Enzymatic incorporation of LNA nucleotides into DNA strands.

scientific article published in March 2007

Enzymatic polymerisation involving 2′-amino-LNA nucleotides

scientific article published on 28 March 2012

Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides

scientific article

Erratum to: mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

scientific article published in May 2015

Evaluation of Oligonucleotides with Novel Modifications

Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis

scientific article

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.

scientific article published on 20 June 2017

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

scientific article published on 18 December 2018

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

scientific article published in April 2018

Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

scientific article

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

scientific article published on 5 February 2016

Fluorescent oligonucleotides containing a novel perylene 2′-amino-α-L-LNA monomer: Synthesis and analytical potential

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

scientific article published on 6 April 2017

Functionalization of 2'-amino-LNA with additional nucleobases.

scientific article published on 19 March 2009

Functionalization of 2″-C-(Piperazinomethyl)-2′,3′-BcNA (Bicyclic Nucleic Acids) with Pyren-1-ylcarbonyl Units

Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

scientific article

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

scientific article

Gapmer Antisense Oligonucleotides Containing 2',3'-Dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing

scientific article published on 20 January 2020

Highly fluorescent conjugated pyrenes in nucleic acid probes: (phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids.

scientific article

Hybridization-based detection of Helicobacter pylori at human body temperature using advanced locked nucleic acid (LNA) probes

scientific article

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury.

scientific article

Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

scientific article published on 25 September 2013

Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

scientific article

Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

scientific article published on 15 October 2020

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

scientific article published on 22 February 2019

Improved Synthesis of 2′-Amino-LNA

scientific article published on 01 May 2003

Improved silencing properties using small internally segmented interfering RNAs

scientific article

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

scientific article

Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions.

scientific article published on 03 April 2014

In Vitro Incorporation of LNA Nucleotides

scientific article published on 01 January 2007

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages

scientific article published on 01 January 2020

In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

scientific article

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

scientific article

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

scientific article

Inside Back Cover: Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex (Chem. Eur. J. 39/2017)

Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.

scientific article

Interfacing click chemistry with automated oligonucleotide synthesis for the preparation of fluorescent DNA probes containing internal xanthene and cyanine dyes.

scientific article

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides

scientific article published on 22 June 2007

LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.

scientific article published on April 2001

LNA 5'-phosphoramidites for 5'→3'-oligonucleotide synthesis

scientific article published on 3 September 2010

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

scientific article published on 8 September 2017

LNA for optimization of fluorescent oligonucleotide probes: improved spectral properties and target binding.

scientific article

LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes

scientific article

LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state.

scientific article

LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.

scientific article published in November 2002

Large Scale Synthesis of 2′-Amino-LNA Thymine and 5-Methylcytosine Nucleosides

scientific article published on 26 November 2012

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

scientific article

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics

scientific article published on 01 January 2005

Locked nucleic acid and aptamers

scientific article published on December 2012

Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers.

scientific article published on 15 May 2009

Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology.

scientific article published in January 2004

Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies

scientific article published in December 2004

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.

scientific article published on March 2010

Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets

scientific article

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

scientific article published on 10 May 2011

Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part 4: Hyperbolic Activation of Rat Liver Microsomal NADPH-Cytochrome C Reductase by the Novel Acetylator 7,8-Diacetoxy-4-methylcoumarin

scientific article published on 01 February 1999

Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part I: Dioxygenated 4-Methyl Coumarins as Superb Antioxidant and Radical Scavenging Agents

scientific article published on 01 June 1998

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-Methylcoumarins mediated by the formation of a stable ADP-Fe-Inhibitor

scientific article published on 01 November 1998

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin

scientific article published on 01 September 1999

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 6: hydrolysis of 7,8-diacetoxy-4-methylcoumarin by a novel deacetylase in rat liver microsomes — a simple method for assay and characterisation

scientific article published on 01 January 2000

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 7: assay and characterization of 7,8-diacetoxy-4-methylcoumarin:protein transacetylase from rat liver microsomes based on the irreversible inhibition of cytosolic glutathi

scientific article published on 01 July 2000

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B 1 –DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin

scientific article published on 01 October 1998

Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom.

scientific article published in May 2001

Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage.

scientific article

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

scholarly article by Annalisa Ferino published in October 2018

Minimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library.

scientific article

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

scientific article published on 21 January 2015

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

scientific article published on 01 July 2018

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

scientific article

Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization

scientific article published on 7 February 2012

Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers

scientific article published on 26 November 2010

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

scientific article published on 24 May 2019

Multifunctional nucleic acids for tumor cell treatment.

scientific article published on 04 February 2014

Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays

scientific article published in September 2005

N-methylpiperazinocarbonyl-2',3'-BcNA and 4'-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

scientific article published on 01 July 2003

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.

scientific article published in January 2007

NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution Structure of an LNA:RNA Hybrid and Characterization of an LNA:DNA Hybrid

scientific article published on 01 May 2004

NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation

scientific article

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration

scientific article

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

scientific article

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation

scientific article published on 29 August 2020

Novel (phenylethynyl)pyrene-LNA constructs for fluorescence SNP sensing in polymorphic nucleic acid targets.

scientific article

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

scientific article published on 01 November 2019

Novel bicyclic nucleoside analogue (1S,5S,6S)-6- hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: synthesis and incorporation into oligodeoxynucleotides

scientific article published in August 2001

Novel chemoselective de-esterification of esters of polyacetoxy aromatic acids by lipases

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

scientific article published on 2 February 2018

Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases

scientific article published on 9 November 2010

Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing

scientific article published on 04 October 2010

Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides

scientific article published in January 2007

Nucleic acid nanotechnology-towards Angstrom-scale engineering.

scientific article published on 22 December 2003

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites

scientific article published on 19 August 2008

Nucleosides with 1,4-dioxane as sugar moiety

scientific article

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

scientific article

Oligodeoxynucleotides containing alpha-L-ribo configured LNA-type C-aryl nucleotides

scientific article

Oligonucleotide Binding to Non-B-DNA in

scientific article published on 12 March 2019

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA.

scholarly article

Oligonucleotides Targeting DNA Repeats Downregulate <i>Huntingtin</i> Gene Expression in Huntington's Patient-Derived Neural Model System

scientific article published on 13 September 2021

Oligonucleotides containing 4'-C-aminomethyl-2'-modified thymidines show increased binding affinity towards DNA and RNA.

scientific article

Oligonucleotides containing a piperazino-modified 2′-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance

scientific article published on 01 March 2015

Oligonucleotides with 1,4-Dioxane-Based Nucleotide Monomers

scientific article published on 02 April 2012

On the influence of conformational locking of sugar moieties on the absorption and circular dichroism of nucleosides from synchrotron radiation experiments

article by Anne I.S. Holm et al published April 2007 in Journal of Photochemistry and Photobiology A

Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.

scientific article published on 3 February 2005

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.

scientific article

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

article

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

scientific article

Peptide-LNA oligonucleotide conjugates.

scientific article published on July 2013

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic.

scientific article published on 28 July 2016

Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.

scientific article published on 5 September 2008

Photoinduced reductive electron transfer in LNA:DNA hybrids: a compromise between conformation and base stacking

scientific article published on 3 September 2012

Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers

scientific article published on 20 October 2011

Polyamine-functionalized 2'-amino-LNA in oligonucleotides: Facile synthesis of novel monomers and high affinity binding towards ssDNA and dsDNA

scientific article published on 19 October 2020

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates

scientific article published on 6 June 2008

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.

scientific article

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

scientific article published on May 2000

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models.

scientific article

Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties

scientific article published on 07 February 2012

Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes

scientific article published in January 2007

Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA.

scientific article published on 3 May 2007

Reprint of "Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces"

scientific article published in September 2020

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies.

scientific article published on 17 May 2017

SYNTHESIS OF A 2′-AMINO-α-L-LNA-T PHOSPHORAMIDITE

scientific article published on 01 January 2005

Scaffolding along nucleic acid duplexes using 2'-amino-locked nucleic acids.

scientific article published on 21 April 2014

Selection of LNA-containing DNA aptamers against recombinant human CD73.

scientific article published on May 2015

Selective Biocatalytic Acylation Studies on 5′-O-(4,4′-Dimethoxytrityl)-2′,3′-Secouridine: An Efficient Synthesis of UNA Monomer

scientific article published on 01 January 2012

Selective biocatalytic deacylation studies on furanose triesters: a novel and efficient approach towards bicyclonucleosides

scientific article published on 25 September 2007

Self-assembly of DNA-peptide supermolecules: Coiled-coil peptide structures templated by D-DNA and L-DNA triplexes exhibit chirality-independent but orientation-dependent stabilizing cooperativity

scientific article published on 05 February 2020

Sequence and pH effects of LNA-containing triple helix-forming oligonucleotides: physical chemistry, biochemistry, and modeling studies

scientific article published in April 2004

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding.

scientific article

Solution Structure of an LNA Hybridized to DNA: NMR Study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) Duplex Containing Four Locked Nucleotides

scientific article published on 01 March 2000

Some recent isolation studies from potential insecticidal Piper species

article

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

scientific article

Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers

scientific article published on 01 June 2008

Stepping towards highly flexible aptamers: enzymatic recognition studies of unlocked nucleic acid nucleotides.

scientific article

Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach

scientific article published in April 2001

Stereoselective synthesis of C-branched nucleoside analogues

Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives

scientific article published on September 1995

Structural Characterization of LNA and α-L-LNA Hybridized to RNA

scientific article published on 01 May 2003

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

scientific article

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA.

scientific article published on 5 March 2018

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2'-Amino-LNA Monomers

scientific article published on 13 October 2016

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units.

scientific article

Synthesis and Hybridization Studies of 2‘-Amino-α-L-LNA and Tetracyclic “Locked LNA”†

scientific article published on 01 May 2006

Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives

scientific article published in 2020

Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

scientific article published on April 2005

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).

scientific article published on January 2005

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

scientific article published on February 2005

Synthesis and biophysical properties of oligodeoxynucleotides containing 2'-deoxy-5-(4-nitro-1H-imidazol-1-yl)-beta-D-uridine and 2'-deoxy-5-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-beta-D-uridine monomers

scientific article published in February 2010

Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.

scientific article published in January 2007

Synthesis and biophysical studies of coronene functionalized 2'-amino-LNA: a novel class of fluorescent nucleic acids

scientific article published on 25 January 2010

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA

scientific article published on 11 December 2013

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary

scientific article published on 01 January 1995

Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine.

scientific article published on May 2003

Synthesis and properties of α- and β-oligodeoxynucleotides containing α- and β-1-(2-O-methyl-d-arabinofuranosyl)thymine

scientific article published on 01 August 1996

Synthesis and structural characterization of 2'-fluoro-α-L-RNA-modified oligonucleotides.

scientific article

Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA.

scientific article

Synthesis of 1-(3-(1,2,4-triazol-1-yl)-2,3,6-trideoxy-L-arabino-hexofuranosyl)uracils via an ?,?-unsaturated aldehydrohexose

Synthesis of 2'-amino-LNA: a new strategy.

scientific article published in February 2003

Synthesis of 2′-Spiro Ribo- and Arabinonucleosides

scientific article published on 01 May 2003

Synthesis of Abasic Locked Nucleic Acid and Twoseco-LNA Derivatives and Evaluation of Their Hybridization Properties Compared with Their More Flexible DNA Counterparts

scientific article published on 01 August 2000

Synthesis of a base-protected alpha-L-LNA guanine nucleoside

scientific article published in May 2003

Synthesis of a base-protected xylo-LNA adenine nucleoside

scientific article published in May 2003

Synthesis of a novel bicyclic nucleoside restricted to an S-type conformation and initial evaluation of its hybridization properties when incorporated into oligodeoxynucleotides.

scientific article

Synthesis of an asymmetrically substituted AZA crown ether as metal and amino acid binding site in DNA conjugates.

scientific article published on May 2003

Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes.

scientific article

Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3′- O ,4′- C -methylene-linked α- l -ribonucleotides

scientific article published on 18 May 2006

Synthetic genetic polymers capable of heredity and evolution

scientific article

Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides

scientific article published on 30 October 2019

Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy

scientific article published on 23 December 2019

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition.

scientific article published on 13 May 2015

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides.

scientific article

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.

scientific article

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

scientific article published on 12 February 2019

The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences

scientific article published in April 2001

The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes.

scientific article published in October 2007

The conformations of locked nucleic acids (LNA)

scientific article published on 01 January 2000

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

scientific article published on 28 April 2009

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

scientific article published on 01 August 1998

The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level

scientific article published on 11 December 2007

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer

scientific article

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative.

scientific article published on 30 December 2017

Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes.

scientific article

Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand.

scientific article published on 03 January 2008

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

scientific article published on 27 April 2015

Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity.

scientific article published on 29 March 2004

Triplex-forming ability of modified oligonucleotides

scientific article published in January 2007

UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

scientific article published on 27 June 2009

Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer.

scientific article published in October 2001

Unlocked Nucleic Acids with a Pyrene-Modified Uracil: Synthesis, Hybridization Studies, Fluorescent Properties and i-Motif Stability

scientific article published on 01 January 2014

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: towards allele-specific genotype detection of human platelet antigens

scholarly article in RSC Advances, vol. 8 no. 57, 2018

Unlocked nucleic acid--an RNA modification with broad potential.

scientific article published on 23 March 2011

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

scientific article published on 9 February 2010

Watson-Crick hydrogen bonding of unlocked nucleic acids.

scientific article published on 20 October 2015

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

Xylo-Configured oligonucleotides (XNA, xylo nucleic acid): synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements.

scientific article

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

scientific article

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

scientific article published on 09 April 2019

xylo-configured oligonucleotides (XNA, xylo nucleic acids): synthesis and hybridization studies

scientific article published in May 2003

α-l-LNA (α-i-riboConfigured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations

article

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