Search filters

List of works by Jordi Alberch

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway

scientific article published on 24 May 2017

A FBN1 3'UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in Marfan syndrome

scientific article published on 30 October 2018

A brain-derived neurotrophic factor (BDNF) related system is involved in the maintenance of the polyinnervate Torpedo electric organ

scientific article published in July 1997

A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease

scientific article

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

scientific article published on 29 May 2013

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

scientific article

Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease

scientific article

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

scientific article published on 6 July 2012

Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3.

scientific article

Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF.

scientific article published on 6 November 2017

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

scientific article published on 26 January 2009

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

scientific article published on 12 August 2010

Analysis of antibodies to neuronal surface antigens in adult opsoclonus–myoclonus

scientific article published on 30 May 2008

Association between BDNF Val66Met polymorphism and age at onset in Huntington disease.

scientific article published in September 2005

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

scientific article published on 01 June 2020

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.

scientific article published on 30 July 2015

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

scientific article published on 13 May 2010

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

scientific article

BMP-2 and cAMP elevation confer locus coeruleus neurons responsiveness to multiple neurotrophic factors

scientific article published on March 2002

Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors.

scientific article published in February 2011

Bax deficiency promotes an up-regulation of Bim(EL) and Bak during striatal and cortical postnatal development, and after excitotoxic injury.

scientific article

Bone morphogenetic protein-2, but not bone morphogenetic protein-7, promotes dendritic growth and calbindin phenotype in cultured rat striatal neurons

scientific article published in January 2001

Bone morphogenetic protein-6 is a neurotrophic factor for calbindin-positive striatal neurons

scientific article

Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins

scientific article published on 01 January 1995

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease

scientific article

Brain-derived neurotrophic factor (BDNF) mediates bone morphogenetic protein-2 (BMP-2) effects on cultured striatal neurones

scientific article

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease

scientific article published in June 2005

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

scientific article

Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum.

scientific article published on February 2005

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

scientific article published on September 2004

Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo

scientific article

Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease

scientific article

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells

scientific article published on 24 January 2008

Cdk5 Contributes to Huntington's Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates.

scientific article published on 29 December 2017

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease

scientific article published on 2 July 2015

Chelerythrine promotes Ca2+-dependent calpain activation in neuronal cells in a PKC-independent manner.

scientific article published on 24 January 2017

Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms

scientific article

Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease

scientific article published on 30 January 2019

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction

scientific article

Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons

scientific article published on 01 November 1993

Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens

scientific article published on 13 March 2019

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study

scientific article published on 19 August 2009

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

scientific article published on 16 June 2015

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease

scientific article published on 28 May 2020

Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections

scientific article published in September 2000

Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons

scientific article published on July 1999

Differential involvement of phosphatidylinositol 3-kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic effects on cultured striatal neurons.

scientific article published in March 2004

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine

scientific article

Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease

scientific article published in November 1998

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

scientific article published on 8 March 2012

Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine

scientific article published in July 2004

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling

scientific article published on 23 October 2007

Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice.

scientific article

Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.

scientific article published on October 2008

Dopaminergic system mediates only delta-opiate inhibition of endogenous acetylcholine release evoked by glutamate from rat striatal slices

scientific article published in January 1991

Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide

scientific article

Early Downregulation of p75NTR by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice.

scientific article

Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.

scientific article published on 30 July 2013

Effect of glatiramer acetate (Copaxone) on the immunophenotypic and cytokine profile and BDNF production in multiple sclerosis: a longitudinal study

scientific article published on 24 August 2006

Effect of opioids on acetylcholine release evoked by K+ or glutamic acid from rat neostriatal slices

scientific article published in July 1990

Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury

scientific article published on 28 January 2005

Evolution of brain-derived neurotrophic factor levels after autologous hematopietic stem cell transplantation in multiple sclerosis

scientific article published in February 2005

Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum

scientific article published on April 2002

Excitatory amino acids release endogenous acetylcholine from rat striatal slices: Regulation by gamma-aminobutyric acid

scientific article published on 01 January 1990

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

scientific article published on 10 June 2015

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

scientific article

GABAA and GABAB antagonists prevent the opioid inhibition of endogenous acetylcholine release evoked by glutamate from rat neostriatal slices

scientific article published in December 1990

Glial cell line-derived neurotrophic factor promotes the arborization of cultured striatal neurons through the p42/p44 mitogen-activated protein kinase pathway

scientific article published on January 2006

Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage

scientific article published on November 1996

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons

scientific article

Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation

scientific article published on 08 November 2019

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

scientific article

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation

scientific article published on 30 April 2020

Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression

scientific article published on 30 May 2018

Huntington's disease: novel therapeutic perspectives hanging in the balance.

scientific article published on 19 April 2018

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

scientific article

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.

scientific article published on 18 April 2013

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

scientific article published on 31 October 2011

Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration.

scientific article published on 19 February 2018

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

scientific article

Increased translation as a novel pathogenic mechanism in Huntington's disease

scientific article published on 01 October 2019

Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease

scientific article

Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells.

scientific article published on September 2007

Intrastriatal grafting of a GDNF-producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivo

scientific article published in January 1999

Involvement of nerve growth factor and its receptor in the regulation of the cholinergic function in aged rats

scientific article

Localization of the neuronal antigen recognized by anti-Tr antibodies from patients with paraneoplastic cerebellar degeneration and Hodgkin's disease in the rat nervous system.

scientific article

Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules

scientific article published on August 2005

Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.

scientific article

Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease

scientific article published on 02 August 2016

Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease

scientific article published on 6 April 2016

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

scientific article published on 7 October 2010

M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease

scientific article published on 05 October 2020

Metabolic profiling for the identification of Huntington biomarkers by on-line solid-phase extraction capillary electrophoresis mass spectrometry combined with advanced data analysis tools

scientific article

Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors

scientific article published in November 2006

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

scientific article published on 09 June 2020

Modulation of the endogenous acetylcholine release from rat striatal slices

scientific article published in November 1985

Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism.

scientific article published on December 2006

Neostriatal dopaminergic terminals prevent the GABAergic involvement in the mu- and delta-opioid inhibition of KCl-evoked endogenous acetylcholine release

scientific article

Nerve growth factor and basic fibroblast growth factor protect cholinergic neurons against quinolinic acid excitotoxicity in rat neostriatum

scientific article published in May 1994

Nerve growth factor and its receptor are differentially modified by chronic naltrexone treatment during rat brain development

scientific article published in January 1993

Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety

scientific article published on 18 April 2013

Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells.

scientific article

Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease.

scientific article

Neuroprotection of striatal neurons against kainate excitotoxicity by neurotrophins and GDNF family members

scientific article

Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction

scientific article

Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease

scientific article

Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling

scientific article

Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice

scientific article

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model

scientific article published on 29 April 2013

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

scientific article

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.

scientific article published on 7 August 2014

Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease

scientific article published on 31 August 2018

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease.

scientific article published on 10 March 2018

Postnatal development of functional dopamine, opioid and tachykinin receptors that regulate acetylcholine release from rat neostriatal slices. Effect of 6-hydroxydopamine lesion.

scientific article

Prenatal haloperidol treatment decreases nerve growth factor receptor and mRNA in neonate rat forebrain

scientific article published in October 1991

Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease

scientific article published on 7 November 2013

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity.

scientific article published on 11 September 2015

Protective Role of Nerve Growth Factor against Excitatory Amino Acid Injury during Neostriatal Cholinergic Neurons Postnatal Development ⬇️

scientific article published on 01 October 1995

Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning

scientific article published on 12 June 2018

Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons

scientific article published on 01 March 2022

Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes

scientific article published on 15 January 2019

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model

scientific article published on 30 May 2017

Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons

scientific article published on 16 September 2015

RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death

scientific article published on 16 April 2015

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

scientific article published on 4 September 2009

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

scientific article published in February 2006

Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease

scientific article published on September 2002

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease

scientific article

Repeated intracerebroventricular administration of beta-amyloid(25-35) to rats decreases muscarinic receptors in cerebral cortex

scientific article published on January 2000

Selective resistance of tachykinin-responsive cholinergic neurons in the quinolinic acid lesioned neostriatum

scientific article published in February 1993

Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase

scientific article published on 01 January 2018

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity

scientific article (publication date: June 2011)

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition

scientific article published on 11 August 2015

Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's disease

scientific article published on March 2002

Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease

scientific article published on 30 July 2020

Tachykinins protect cholinergic neurons from quinolinic acid excitotoxicity in striatal cultures

scientific article published in November 1996

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.

scientific article published on 16 March 2013

The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice.

scientific article published on 8 June 2017

The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum.

scientific article

The vulnerability of striatal projection neurons and interneurons to excitotoxicity is differentially regulated by dopamine during development

scientific article published on 21 January 2005

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression

scientific article published on 7 August 2012

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

scientific article published on 11 September 2006

TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal ganglia

scientific article published in December 2001

Unilateral neonatal hippocampal lesion alters septal innervation and trophism of the entorhinal cortex

scientific article published in September 1996

Paulina is supported by:

About Paulina

Help