List of works - Marco De Amici

2020 Italian Special Anniversary Collection: Celebrating NMMC 2019 and 40 Years of the DCF-SCI

scientific article published on 23 December 2020

A chemoenzymatic approach to the synthesis of the stereoisomers of a β-adrenergic receptor antagonist

A combinatorial biocatalysis approach to an array of cholic acid derivatives

scientific article

A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors

scholarly article by Carlo Matera et al published 17 April 2014 in Monatshefte für Chemie

A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake

scientific article

Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.

scientific article published on May 2013

Allosteric Modulation of Alpha7 Nicotinic Receptors: Mechanistic Insight through Metadynamics and Essential Dynamics

scientific article published on 16 November 2015

Allosteric Modulators and Selective Agonists of Muscarinic Receptors

scientific article published on 01 January 2006

Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities

scientific article published on May 2010

Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics Poisson-Boltzmann surface area approach

scientific article published in November 2008

Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization

scientific article published on 20 June 2015

Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity

scientific article

Chemoenzymatic synthesis of acetyl (R)-(+)- and (S)-(−)-cycloserine

Chemoenzymatic synthesis of the enantiomers of desoxymuscarine

Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives

Design of new analogues of glutamic acid with a conformationally restricted structure

scientific article published in March 2000

Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies

scientific article published on 24 September 2009

Design of novel conformationally restricted analogues of glutamic acid

Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors

scientific article published in January 2006

Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors

scientific article

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

scientific article published in December 2004

Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques

scientific article published in January 2010

Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit

scientific article published in August 2005

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

scientific article published on 8 October 2008

Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.

scientific article

Enantiopure stereoisomeric homologues of glutamic acid: chemoenzymatic synthesis and assignment of their absolute configurations

Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors

scientific article published on 21 July 2011

Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes

scientific article published on 10 July 2008

Evidence for specific analgesic activity of a muscarinic agonist selected among a new series of acetylenic derivatives

scientific article

Inactivation of TEM-1 by Avibactam (NXL-104): Insights from Quantum Mechanics/Molecular Mechanics Metadynamics Simulations

scientific article published on 30 July 2014

Insight into the Mechanism of Hydrolysis of Meropenem by OXA-23 Serine-β-lactamase Gained by Quantum Mechanics/Molecular Mechanics Calculations

scientific article

Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes

scientific article

Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation

scientific article

Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

scientific article published on 13 June 2016

Metal-hydride reduction of isoxazoline-3-carboxylate esters

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype

scientific article

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reupta

scientific article

New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations

scientific article published in February 2009

New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes.

scientific article published in June 2000

New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo

scientific article published on 23 May 2014

New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors

scientific article

Nitrile oxides in medicinal chemistry-2. synthesis of the two enantiomers of dihydromuscimol

Nitrile oxides in medicinal chemistry. 5. Lipase PS-catalyzed resolution of a set of heterocyclic derivatives

Nitrile oxides in medicinal chemistry. 6. Enzymatic resolution of a set of bicyclic Δ2-isoxazolines

Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes

scientific article published on 2 February 2007

Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes

scientific article

Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes

scientific article published on 27 April 2010

On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships

scientific article published on 28 April 2015

Pharmacological profile of enantiomerically pure chiral muscarinic agonists: desoxymuscarines

scientific article published in June 2000

Rational design of dualsteric GPCR ligands: quests and promise

scientific article published on 05 February 2010

Stereoselectivities of mesitonitrile oxide cycloadditions to 7-substituted norbornadienes

Synthesis and Pharmacological Characterization of Enantiomerically Pure Muscarinic Agonists: Difluoromuscarines

scientific article published on 01 March 1997

Synthesis and Pharmacology of a New AMPA−Kainate Receptor Agonist with Potent Convulsant Activity

scientific article published on 01 September 1998

Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids

scientific article

Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine

scientific article published in 1997

Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin

scientific article published on September 2003

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.

scientific article

Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.

scientific article published in August 1999

Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands

scientific article published in September 2003

Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof

scholarly article by Paola Conti et al published March 2007 in Tetrahedron

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid

scientific article

Synthesis and pharmacological characterization of new chiral derivatives of muscarine and allo-muscarine.

scientific article published in August 2000

Synthesis and pharmacological investigation of cholinergic ligands structurally related to muscarone

scholarly article by Marco De Amici et al published March 1989 in European Journal of Medicinal Chemistry

Synthesis and pharmacological investigation of stereoisomeric muscarines

scientific article published in January 1992

Synthesis and pharmacological investigation of the 3-analogs of viminol

scholarly article by Marco De Amici et al published November 1988 in European Journal of Medicinal Chemistry

Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

scientific article

Synthesis of 3-Hydroxy- and 3-Carboxy-Δ2-isoxazoline Amino Acids and Evaluation of Their Interaction with GABA Receptors and Transporters

Synthesis of Epibatidine-Related Δ2-Isoxazoline Derivatives and Evaluation of Their Binding Affinity at Neuronal Nicotinic Acetylcholine Receptors

Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters

Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes

scientific article published on 10 March 2006

Synthesis of new bicyclic analogues of glutamic acid

Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes

scientific article published on 17 September 2010

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

scientific article

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

scientific article

The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors

List of works by Marco De Amici

2020 Italian Special Anniversary Collection: Celebrating NMMC 2019 and 40 Years of the DCF-SCI

A chemoenzymatic approach to the synthesis of the stereoisomers of a β-adrenergic receptor antagonist

A combinatorial biocatalysis approach to an array of cholic acid derivatives

A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors

A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake

Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.

Allosteric Modulation of Alpha7 Nicotinic Receptors: Mechanistic Insight through Metadynamics and Essential Dynamics

Allosteric Modulators and Selective Agonists of Muscarinic Receptors

Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities

Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics Poisson-Boltzmann surface area approach

Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization

Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity

Chemoenzymatic synthesis of acetyl (R)-(+)- and (S)-(−)-cycloserine

Chemoenzymatic synthesis of the enantiomers of desoxymuscarine

Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives

Design of new analogues of glutamic acid with a conformationally restricted structure

Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies

Design of novel conformationally restricted analogues of glutamic acid

Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors

Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques

Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.

Enantiopure stereoisomeric homologues of glutamic acid: chemoenzymatic synthesis and assignment of their absolute configurations

Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors

Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes

Evidence for specific analgesic activity of a muscarinic agonist selected among a new series of acetylenic derivatives

Inactivation of TEM-1 by Avibactam (NXL-104): Insights from Quantum Mechanics/Molecular Mechanics Metadynamics Simulations

Insight into the Mechanism of Hydrolysis of Meropenem by OXA-23 Serine-β-lactamase Gained by Quantum Mechanics/Molecular Mechanics Calculations

Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes

Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation

Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

Metal-hydride reduction of isoxazoline-3-carboxylate esters

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reupta

New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations

New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes.

New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo

New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors

Nitrile oxides in medicinal chemistry-2. synthesis of the two enantiomers of dihydromuscimol

Nitrile oxides in medicinal chemistry. 5. Lipase PS-catalyzed resolution of a set of heterocyclic derivatives

Nitrile oxides in medicinal chemistry. 6. Enzymatic resolution of a set of bicyclic Δ2-isoxazolines

Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes

Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes

Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes

On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships

Pharmacological profile of enantiomerically pure chiral muscarinic agonists: desoxymuscarines

Rational design of dualsteric GPCR ligands: quests and promise

Stereoselectivities of mesitonitrile oxide cycloadditions to 7-substituted norbornadienes

Synthesis and Pharmacological Characterization of Enantiomerically Pure Muscarinic Agonists: Difluoromuscarines

Synthesis and Pharmacology of a New AMPA−Kainate Receptor Agonist with Potent Convulsant Activity

Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids

Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine

Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.

Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.

Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands

Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid

Synthesis and pharmacological characterization of new chiral derivatives of muscarine and allo-muscarine.

Synthesis and pharmacological investigation of cholinergic ligands structurally related to muscarone

Synthesis and pharmacological investigation of stereoisomeric muscarines

Synthesis and pharmacological investigation of the 3-analogs of viminol

Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

Synthesis of 3-Hydroxy- and 3-Carboxy-Δ2-isoxazoline Amino Acids and Evaluation of Their Interaction with GABA Receptors and Transporters

Synthesis of Epibatidine-Related Δ2-Isoxazoline Derivatives and Evaluation of Their Binding Affinity at Neuronal Nicotinic Acetylcholine Receptors

Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters

Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes

Synthesis of new bicyclic analogues of glutamic acid

Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors

β 3 -Adrenergic receptor ligands: insight into structure–activity relationships using Monte-Carlo conformational analysis in water