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List of works by Shigetsugu Hatakeyama

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.

scientific article published on 26 February 2013

A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

scientific article published on 20 October 2020

APS-mediated ubiquitination of the insulin receptor enhances its internalization, but does not induce its degradation.

scientific article published on 14 November 2006

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

scientific article

Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation ⬇️

scientific article published on December 10, 2012

Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2.

scientific article published on 8 February 2018

Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts

scientific article published on 08 September 2019

Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure

scientific article published on 01 October 2018

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

scientific article published in July 2004

Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60

scientific article

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10

scientific journal article

Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a

scientific journal article

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

scientific article published on October 1999

Csk overexpression reduces several monokines and nitric oxide productions but enhances prostaglandin E2 production in response to lipopolysaccharide in the macrophage cell line J774A.1.

scientific article published on March 1997

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

scientific article

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

scientific article published on September 2006

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

scientific article published on 26 October 2001

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

scientific article published on 18 August 2003

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

scientific article published on May 1999

Early evidence for the role of TRIM29 in multiple cancer models

scientific article published on 15 February 2016

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

scientific article

Establishment of a newly improved detection system for NF-kappaB activity.

scientific article published on 13 March 2007

Expression of recombinant sea urchin cellulase SnEG54 using mammalian cell lines.

scientific article published on 8 April 2010

Fine-tuning of thymocyte development by ubiquitination-mediated stability control of the ESCRT protein CHMP5.

scientific article published on 11 September 2017

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis

scientific journal article

Functional significance of the Fas molecule in naive lymphocytes

scientific article published on 01 March 1996

Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration

scientific article published on 30 March 2009

Identification of Developmentally Expressed Proteins That Functionally Interact with Nedd4 Ubiquitin Ligase ⬇️

scientific article published on November 20, 2001

Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy

scientific article published on 23 November 2013

Inhibition of NF-kappaB signaling via tyrosine phosphorylation of Ymer.

scientific article

Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones

scientific article

Involvement of Rabring7 in EGF receptor degradation as an E3 ligase

scientific article

Large-scale analysis of the human ubiquitin-related proteome

scientific article published on November 2005

Leukemogenic kinase FIP1L1-PDGFRA and a small ubiquitin-like modifier E3 ligase, PIAS1, form a positive cross-talk through their enzymatic activities

scientific article published on 13 December 2016

Loss of TRIM29 alters keratin distribution to promote cell invasion in squamous cell carcinoma

scientific article published on 02 November 2018

MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif.

scientific article published on 27 February 2011

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

scientific article published on 9 January 2015

Mapping of ubiquitination sites on target proteins

scientific article published on January 2005

Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling

scientific article published on 30 March 2015

Molecular clearance of ataxin-3 is regulated by a mammalian E4

scientific article

Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

scientific article published on October 1999

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

scientific article published on 12 December 2003

Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome.

scientific article published on 16 January 2018

Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein

scientific article

Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase

scientific article

Pathology of frontotemporal dementia with limb girdle muscular dystrophy caused by a DNAJB6 mutation

scientific article published on 2 October 2014

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

scientific article

Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin

scientific article

Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.

scientific article published on April 2003

Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1.

scientific article published on 17 November 2006

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

scientific article

RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis

scientific article published on 07 July 2020

RNF43 interacts with NEDL1 and regulates p53-mediated transcription.

scientific article

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

scientific article published on 6 July 2016

Regulation of the level of Vesl-1S/Homer-1a proteins by ubiquitin-proteasome proteolytic systems

scientific article published on 21 February 2001

Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.

scientific article

Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system.

scientific article published on 26 November 2007

Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein I antibodies

scientific article published on 9 March 2016

Sez6l2 regulates phosphorylation of ADD and neuritogenesis.

scientific article published on 11 October 2017

Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis

scientific article published in February 2015

Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/Akt and Erk pathways in association with signaling Adaptor DAP12.

scientific article

Skp2-mediated degradation of p27 regulates progression into mitosis

scientific article published in May 2004

Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development

scientific article

Structure and expression of the gene encoding mouse F-box protein, Fwd2.

scientific article

Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner

scientific article published on 17 May 2004

Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases

scientific article (publication date: 13 June 1997)

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis.

scientific article published on 21 January 2017

TRIM proteins and cancer

scientific article published on 7 October 2011

TRIM proteins and diseases

scientific article published on 7 January 2017

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

scientific article

TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer

scientific article published on 30 January 2014

TRIM29 negatively regulates p53 via inhibition of Tip60.

scientific article published on 2 April 2011

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin

scientific article

TRIM29 regulates the p63-mediated pathway in cervical cancer cells

scientific article published on 10 June 2015

TRIM29 suppresses TWIST1 and invasive breast cancer behavior.

scientific article

TRIM31 interacts with p52(Shc) and inhibits Src-induced anchorage-independent growth.

scientific article published on 8 August 2009

TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription

scientific article published on 7 October 2011

TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60.

scientific article

TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin

scientific article published on 12 September 2015

TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers

scientific article

TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation

scientific article published on 23 May 2012

TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways

scientific article

TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3.

scientific article published on 31 January 2018

TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells ⬇️

scientific article published on February 10, 2012

TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis

scientific journal article

TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells

scientific article

TRIM8 modulates STAT3 activity through negative regulation of PIAS3.

scientific article published on June 2010

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

scientific journal article

Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation

scientific article published on September 2005

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

scientific article published on 19 January 2001

The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.

scientific article published on 31 March 2014

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.

scientific article published on 24 September 2016

The role of Mediator and Little Elongation Complex in transcription termination

scientific article published on 26 February 2020

Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2

scientific article

U box proteins as a new family of ubiquitin-protein ligases

scientific article

U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

scientific article published on October 2004

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.

scientific article published on 13 February 2011

Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.

scientific article

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

scientific article

Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells

scientific article published on July 2012

Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.

scientific article

Ubiquitylation as a quality control system for intracellular proteins.

scientific article

Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA

scientific article published on 25 August 2007

ZNRF1 interacts with tubulin and regulates cell morphogenesis

scientific article published on 06 September 2009

p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex

scientific article published on 3 June 2016

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