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List of works by Randall J. Bateman

A LONGITUDINAL MORPHOMETRIC STUDY OF FAMILIAL ALZHEIMER’S DISEASE: RESULTS FROM DIAN

A LONGITUDINAL MORPHOMETRIC STUDY OF FAMILIAL ALZHEIMER’S DISEASE: RESULTS FROM DIAN

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

scientific article published on July 2009

A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials

scientific article published on 07 September 2019

A novel PSEN1 (S230N) mutation causing early-onset Alzheimer's Disease associated with prosopagnosia, hoarding, and Parkinsonism.

scientific article published on 29 July 2017

A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer's disease

scientific article published on 14 May 2018

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

scientific article published on 17 June 2016

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

scientific article published on 7 March 2016

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

scientific article published on 11 March 2020

A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer's disease

scientific article published on 22 July 2015

A voxel-based morphometry study of volumetric MRI in familial Alzheimer's disease

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound

scientific article

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

scientific article

Age and amyloid effects on human central nervous system amyloid-beta kinetics

scientific article

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction

scientific article

Alzheimer's disease

scientific article published on 15 October 2015

Alzheimer's disease and other dementias: advances in 2014.

scientific article

Alzheimer's disease therapeutic trials: EU/US task force report on recruitment, retention, and methodology ⬇️

scientific article published on April 1, 2012

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

scientific article published on 06 February 2020

Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers

scientific article published on 12 August 2019

Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis

scientific article

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

scientific article

Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics

scientific article (publication date: September 2013)

Amyloid-β Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity

scientific article published on 22 March 2018

Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

scientific article

Amyloid-β efflux from the central nervous system into the plasma

scientific article

Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls

scientific article published on 7 December 2012

Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease

scientific article published on January 2012

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

scientific article

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

scientific article published on 07 October 2019

An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

scientific article published on 29 July 2015

Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans

scientific article published on 9 December 2014

Another step forward in blood-based diagnostics for Alzheimer's disease

scientific article published on 01 March 2020

Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease

scientific article published on 05 November 2020

Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent?

article

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

scientific article published on 02 December 2019

Association of education with Aβ burden in preclinicial familial and sporadic Alzheimer disease

scientific article published on 05 August 2020

Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System

scientific article published on 19 December 2016

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

scientific article

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

scientific article published on 01 January 2020

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression

scientific article published on 20 May 2019

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease

scientific article

Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease

scientific article published on 16 November 2020

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease

scientific article published on 01 November 2020

Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study

CAP--advancing the evaluation of preclinical Alzheimer disease treatments

scientific article published on 29 September 2015

CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.

scientific article

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

scholarly article by Marc Suárez-Calvet et al published December 2018 in EMBO Molecular Medicine

CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease

scientific article published on 07 December 2020

Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease

scientific article

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification

scientific article published on 17 March 2020

Challenges, solutions, and recommendations for Alzheimer's disease combination therapy

scientific article

Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease

scientific article published on 06 July 2016

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

scientific article

Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease

scientific article published on 3 October 2016

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease

scientific article published on 01 May 2019

Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials

scientific article

Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease

scientific article published on 05 November 2020

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

article

Continuous 24-hour leptin, proopiomelanocortin, and amino acid measurements in human cerebrospinal fluid: correlations with plasma leptin, soluble leptin receptor, and amino acid levels

scientific article

Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Ratesin the CNS.

scientific article published on 3 July 2012

Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group

scientific article published on 20 September 2016

Cross-sectional and longitudinal associations between plasma neurodegenerative biomarkers and physical performance among community-dwelling older adults

scientific article published on 13 November 2020

Cross-sectional cerebral volumetric differences and associations with estimated time to age-at-onset in familial Alzheimer's disease: Findings from the DIAN study

article

Data-driven models of dominantly-inherited Alzheimer's disease progression

scientific article published on 22 March 2018

Data-driven models of dominantly-inherited Alzheimer's disease progression

scholarly article published 19 January 2018

Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease

scientific article

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

scientific article (publication date: 24 December 2010)

Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: baseline data from a DIAN cohort subset

scientific article

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network

scientific article (publication date: October 2012)

Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study

scientific article

Discovery and validation of autosomal dominant Alzheimer's disease mutations

scientific article published on 18 July 2018

Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology

scientific article published on September 2012

Diurnal oscillation of CSF Aβ and other AD biomarkers

scientific article

Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system

scientific article

Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.

scientific article published on 25 August 2017

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

scientific article published on 17 October 2013

Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes

scientific article published on 23 November 2020

Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network

scientific article published on 15 February 2015

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

scientific article published on December 2016

Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease

scientific article published on 25 August 2018

Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network

scientific article published on 13 October 2018

Effect of sleep on overnight CSF amyloid-β kinetics.

scientific article published on 8 December 2017

Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system

scientific article

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

scientific article published on 04 March 2019

Estimating diagnostic accuracy for clustered ordinal diagnostic groups in the three-class case-Application to the early diagnosis of Alzheimer disease

scientific article published in January 2017

Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry

scientific article

Factors Contributing to the Post-Lumbar Puncture Headache—Reply

scientific article published on July 2015

Factors associated with the onset and persistence of post-lumbar puncture headache

scientific article

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker

scientific article published in February 2007

Functional connectivity in autosomal dominant and late-onset Alzheimer disease

scientific article

Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis

scientific article published on 12 December 2019

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

scientific article published on 8 June 2018

Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

scientific article published on 11 May 2017

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

scientific article published on 01 August 2019

Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma

scientific article

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

scientific article

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

scientific article

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

scientific article published on 25 July 2018

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

scientific article published on 24 July 2013

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS

scientific article (publication date: 2012)

In vivo kinetic approach reveals slow SOD1 turnover in the CNS.

scientific article

Increased Cerebrospinal Fluid Amyloid-β During Sleep Deprivation in Healthy Middle-Aged Adults Is Not Due to Stress or Circadian Disruption

scientific article published on 31 March 2020

Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers

scientific article

Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery

scientific article published on 5 October 2017

Item response theory analysis of the Clinical Dementia Rating

scientific article published on 20 November 2020

LONGITUDINAL ATROPHY IN AUTOSOMAL DOMINANT AD AND SPORADIC AD: LESSONS FROM DIAN

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

scientific article published on 15 February 2018

Linear Combinations of Multiple Outcome Measures to Improve the Power of Efficacy Analysis ---Application to Clinical Trials on Early Stage Alzheimer Disease

scientific article published on 02 June 2017

Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease

scientific article

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

scientific article published on 14 September 2018

Loss of Brain Aerobic Glycolysis in Normal Human Aging.

scientific article

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

scientific article published on 20 June 2006

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

scientific article published in October 2006

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

scientific article

Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease

scientific article published on July 2008

Method for the simultaneous quantitation of apolipoprotein E isoforms using tandem mass spectrometry

scientific article

Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype

scientific article published on 22 August 2020

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects

scientific article

Neurofilament light chain levels in ventricular cerebrospinal fluid after acute aneurysmal subarachnoid haemorrhage.

scientific article published on 22 June 2010

Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).

scientific article

Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN).

scientific article published on 12 May 2015

Partial volume correction in quantitative amyloid imaging

scientific article published on 5 December 2014

Persistent metabolic youth in the aging female brain

scientific article published on 04 February 2019

Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals

scientific article published in 2022

Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults

scientific article published on 08 October 2020

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study

scientific article published on 21 January 2016

Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies

scientific article published in January 2017

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

scientific article

Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning

scientific article published on 11 February 2020

Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing

scientific article published on 7 March 2018

Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations

scientific article published on 24 December 2020

Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study.

scientific article published on 21 July 2017

Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference

scientific article published on 23 September 2014

Protein production is an early biomarker for RNA-targeted therapies

scientific article published on 14 October 2018

Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease

scientific article published on 26 February 2018

Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers

scientific article published on October 2013

Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group

scientific article

Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain

scientific article published on 27 August 2020

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

scientific article

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

scientific article published on 25 September 2018

Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease

scientific article published on 23 June 2020

Reply

Reply to "Excess amyloid beta can be degraded in healthy humans".

scientific article published on 19 February 2018

Reply to comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice".

scientific article published on December 2014

Reply to: Fractional synthesis and clearance rates for amyloid β

Revolutionizing Alzheimer's disease and clinical trials through biomarkers

scientific article

SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases

scientific article published on 20 June 2019

Seizures as an early symptom of autosomal dominant Alzheimer's disease

scientific article published on 05 December 2018

Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study

scientific article published on 01 September 2020

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

scientific article published on 21 January 2019

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

scientific article published on 06 June 2020

Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease

scholarly article by Guoqiao Wang et al published 2018 in Alzheimer's & dementia (New York, N. Y.)

Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease

scientific article published on 15 July 2020

Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid

scientific article published on 14 February 2020

Soluble Amyloid-beta Aggregates from Human Alzheimer's Disease Brains

scientific article published on 05 December 2016

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

scientific article published on 31 January 2018

Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates

scientific article

Stable isotope labeling tandem mass spectrometry (SILT): integration with peptide identification and extension to data-dependent scans

scientific article

Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset

scientific article published on 15 February 2019

Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis

scientific article

Tau Kinetics in Neurons and the Human Central Nervous System

scientific article published on 01 March 2018

Tau Kinetics in Neurons and the Human Central Nervous System

scientific article published on 01 May 2018

Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers

scientific article published on 01 April 2019

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease.

scientific article

Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture

scientific article published on 12 February 2018

Testing a test for Alzheimer disease

scientific article published in February 2007

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

scientific article published on 21 March 2019

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

scientific article

The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.

scientific article published on 15 March 2017

The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study

scientific article published on 18 September 2013

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

scholarly article by Daniel Twohig et al published 26 November 2018 in Acta neuropathologica communications

The structure of amyloid-β dimers in Alzheimer's disease brain: a step forward for oligomers

scientific article published on 01 May 2019

Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease

scientific article published on 05 September 2019

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

scientific article published on 27 September 2018

Validity and power of minimization algorithm in longitudinal analysis of clinical trials

scientific article published on 13 June 2017

Visual involvement in corticobasal syndrome

scientific article published on December 2012

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

article by Miguel Ángel Araque Caballero et al published 1 October 2018 in Brain

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease

scientific article published on 9 May 2018

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

scientific article

β-amyloid dynamics in human plasma

scientific article published on December 2012

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