List of works - Carolyn L. Cummins

1 ,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(-/-) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

scientific article published on 18 March 2011

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

scientific article

3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis

scientific article published on 06 September 2018

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

scholarly article

A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity

scientific article

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids

scientific article

ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development

scientific article published on 01 April 2019

Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism

scientific article published on 12 November 2010

Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *.

scientific article published in December 2007

Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis

scholarly article by Adil Rasheed published in August 2018

CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam

scientific article published on 20 October 2003

Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.

scientific article

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

scientific article

Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).

scientific article published on January 2002

Compound prioritization methods increase rates of chemical probe discovery in model organisms

scientific article

Corrigendum to "EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function" [Behav. Brain Res. 300 (2016) 85-96].

scientific article published on 28 April 2016

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

scientific article published on 6 November 2011

Determination of p-aninosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity

article

Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.

scientific article published on 14 December 2016

EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function

scientific article published on 22 September 2015

Erratum: Corrigendum: Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

scholarly article published in Nature Chemical Biology

Getting the Skinny on Follistatin and Fat

scientific article published on 01 April 2017

Glucocorticoids and Metabolic Control

scientific article published on 28 April 2015

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

scientific article

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

scientific article published on 23 March 2006

Idebenone and coenzyme Q10are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases

scientific article published on 31 August 2018

Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene

scientific article published on 06 June 2008

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

scientific article published on 9 March 2006

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

scientific article published on 10 April 2007

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model

scientific article published in April 2003

Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells

scientific article published on 08 July 2013

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

scientific article

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

scientific article

Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice

scientific article

Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory Conditions

scientific article

Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes

scientific article

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.

scientific article published on December 2006

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice.

scientific article

Liver X receptors regulate adrenal cholesterol balance

scientific article

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

scientific article published on 6 March 2008

Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells.

scientific article

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

scientific article published on 13 May 2015

Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux

scientific article published on 15 February 2022

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

scientific article published in Scientific Reports

Mapping the cellular response to small molecules using chemogenomic fitness signatures

scientific article

Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues

scientific article published on 25 April 2014

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

scientific article published in February 2017

Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control

scientific article

Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model

scientific article published on 01 July 2019

Quantification of Oxysterol Nuclear Receptor Ligands by LC/MS/MS

scientific article published on 01 January 2019

Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

scientific article published on 25 May 2011

Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes

scientific journal article

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes

scientific article published on 7 January 2015

Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism.

scientific article published on 27 January 2017

Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein

scientific article

Strategies and limitations associated with in vitro characterization of vitamin D receptor activators

scientific article published on 18 July 2018

Subchronic glucocorticoids, glutathione depletion and a postpartum model elevate monoamine oxidase a activity in the prefrontal cortex of rats.

scientific article published on 20 April 2017

Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor

scientific article

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids

scientific article published on 27 October 2007

Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output

scientific article published on 21 August 2020

The CRH-Transgenic Cushingoid Mouse Is a Model of Glucocorticoid-Induced Osteoporosis

scientific article published on 28 June 2017

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.

scientific article published on 7 August 2011

The drug efflux-metabolism alliance: biochemical aspects.

scientific article

The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules

scientific article published on 02 September 2019

The secretome of liver X receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr-/- mice

scientific article published on 24 November 2020

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

scientific article

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data ⬇️

scientific article published on October 1, 2003

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

scientific article published on June 2004

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

scientific article published in March 2002

Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

scientific article

List of works by Carolyn L. Cummins

1 ,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(-/-) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids

ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development

Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism

Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *.

Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis

CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam

Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).

Compound prioritization methods increase rates of chemical probe discovery in model organisms

Corrigendum to "EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function" [Behav. Brain Res. 300 (2016) 85-96].

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Determination of p-aninosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity

Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.

EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function

Erratum: Corrigendum: Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

Getting the Skinny on Follistatin and Fat

Glucocorticoids and Metabolic Control

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

Idebenone and coenzyme Q10are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases

Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model

Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice

Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory Conditions

Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice.

Liver X receptors regulate adrenal cholesterol balance

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells.

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

Mapping the cellular response to small molecules using chemogenomic fitness signatures

Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control

Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model

Quantification of Oxysterol Nuclear Receptor Ligands by LC/MS/MS

Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes

Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism.

Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein

Strategies and limitations associated with in vitro characterization of vitamin D receptor activators

Subchronic glucocorticoids, glutathione depletion and a postpartum model elevate monoamine oxidase a activity in the prefrontal cortex of rats.

Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids

Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output

The CRH-Transgenic Cushingoid Mouse Is a Model of Glucocorticoid-Induced Osteoporosis

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.

The drug efflux-metabolism alliance: biochemical aspects.

The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules

The secretome of liver X receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr-/- mice

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data ⬇️

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.